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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

BR serine/threonine kinase 2

BRSK2, BR serine/threonine kinase 2
Top mentioned proteins: AMPK, LKB1, Sad1, Ubiquitin, MARK4
Papers on BRSK2
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
New
Shah et al., Durham, United States. In Plos Genet, Nov 2015
Association of genomewide methylation profiles with SCDA metabolites identified two ER stress genes as differentially methylated (BRSK2 and HOOK2).
Regulatory network of differentially expressed genes in metastatic osteosarcoma.
New
Zhang et al., Shenyang, China. In Mol Med Report, Mar 2015
Brain selective kinase 2 (BRSK2) and aldo‑keto reductase family 1 member B10 (AKRIB10) were present in the screened submodules.
Array-based DNA methylation profiling in male infertility reveals allele-specific DNA methylation in PIWIL1 and PIWIL2.
Bens et al., Kiel, Germany. In Fertil Steril, 2014
We found that 445 (94.5%) of 471 differentially methylated CpGs were associated with SNPs, but 26 (15 genes) were not genomically templated, including the ENO1, MTA2, BRSK2, and LBX2 genes previously associated with fertility and spermatogenesis.
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.
Alessi et al., Dundee, United Kingdom. In Biochem J, 2014
The activity of several of the AMPK-related kinases analysed [BRSK1 (BR serine/threonine kinase 1), BRSK2, NUAK1 (NUAK family, SNF1-like kinase 1), SIK3 (salt-inducible kinase 3) and MARK4 (MAP/microtubule affinity-regulating kinase 4)] was not affected in tissues derived from LKB1S431A/S431A or LKB1C433S/C433S mice.
BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation.
Yu et al., Shanghai, China. In Biotechnol Lett, 2013
BRSK2 (also known as SAD-A), a serine/threonine kinase of the AMP-activated protein kinase family affected VCP/p97 activity in ERAD.
The regulation and function of the NUAK family.
Review
Zhao et al., Taipei, Taiwan. In J Mol Endocrinol, 2013
Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently.
The human PDZome: a gateway to PSD95-Disc large-zonula occludens (PDZ)-mediated functions.
Borg et al., Marseille, France. In Mol Cell Proteomics, 2013
We have demonstrated that this array can efficiently identify interactions using carboxy-terminal sequences of PDZ domain binders such as the E6 oncoviral protein and protein kinases (PDGFRβ, BRSK2, PCTK1, ACVR2B, and HER4); this has been validated via mass spectrometry analysis.
Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.
GeneRIF
Yu et al., Shanghai, China. In J Biol Chem, 2012
a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.
BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.
GeneRIF
Yu et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
these findings demonstrate ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis.
Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.
GeneRIF
Yu et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
these findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1.
Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment.
Lizcano et al., Barcelona, Spain. In Biochim Biophys Acta, 2011
Here we show that brain BRSK1, but not BRSK2, is palmitoylated, and provide biochemical and pharmacological evidences demonstrating that a pool of BRSK1, but not BRSK2 or LKB1, localizes at membrane lipid rafts.
APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.
Yu et al., Shanghai, China. In Plos One, 2011
Studies of brain-specific kinase 2 (BRSK2), an AMP-activated protein kinase (AMPK)-related kinase, and its homologs suggest that they are multifunctional regulators of cell-cycle progression.
[Clinical implication of BRSK2 expression in pancreatic ductal adenocarcinoma].
GeneRIF
Lou et al., Shanghai, China. In Zhonghua Yi Xue Za Zhi, 2010
BRSK2 is up-regulated in pancreatic ductal adenocarcinoma.
The regulation and function of mammalian AMPK-related kinases.
Review
Carling et al., London, United Kingdom. In Acta Physiol (oxf), 2009
Recently, 12 AMPK-related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) were identified that are closely related by sequence homology to the catalytic domain of AMPK.
C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.
GeneRIF
Hardie et al., Dundee, United Kingdom. In J Biol Chem, 2009
STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2
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