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POU class 6 homeobox 1

Brn-5, Pou6f1, Brn-5 protein, brain-5
binds a variant octomer core motif DNA sequence; may act as a transcriptional activator [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Oct-2, ACID, OCT, Brn-3A, ICOS
Papers on Brn-5
Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target.
GeneRIF
Ishizuka et al., Japan. In Int J Gynecol Cancer, 2010
POU6F1 siRNA dose-dependently suppressed the proliferation of clear cell adenocarcinoma cell lines.
POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary.
GeneRIF
Ishizuka et al., Japan. In Hum Cell, 2009
is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary.
Structure of human Brn-5 transcription factor in complex with CRH gene promoter.
GeneRIF
Kim et al., Berkeley, United States. In J Struct Biol, 2009
The crystal structure of human Brn-5 transcription factor in complex with corticotropin-releasing hormone gene promoter reveals an unexpected recognition mode of the protein to its cognate DNA
Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA.
GeneRIF
Kim et al., Berkeley, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008
Crystallization and preliminary X-ray analysis
Involvement of mPOU (Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL.
GeneRIF
Okimura et al., Kōbe, Japan. In Mol Cell Endocrinol, 2008
Brn-5 enhances prolactin gene expression directly in association with Pit-1 and CREB-binding protein, and indirectly via the activation of Pit-1 gene expression.
Identification of evolutionarily conserved, functional noncoding elements in the promoter region of the sodium channel gene SCN8A.
Meisler et al., Ann Arbor, United States. In Mamm Genome, 2007
The conserved elements are most similar to consensus sites for the transcription factors Pou6f1/Brn5, YY1, and REST/NRSF.
The in vivo form of the murine class VI POU protein Emb is larger than that encoded by previously described transcripts.
Buckingham et al., Paris, France. In Gene, 2004
The class VI POU domain family member known as Emb in the mouse (rat Brn5 or human mPOU/TCFbeta1) is present in vivo as a protein migrating at about 80 kDa on western blots, considerably larger than that predicted (about 42 kDa) from previously cloned coding sequences.
The POU gene Brn-5 is induced by neuregulin and is restricted to myelinating Schwann cells.
Weinstein et al., New York City, United States. In Mol Cell Neurosci, 2001
Through these studies we have identified another POU gene, Brn-5, the expression of which has not previously been appreciated in the Schwann cell.
Highly cooperative homodimerization is a conserved property of neural POU proteins.
Turner et al., San Diego, United States. In J Biol Chem, 1999
Here, we have used random oligonucleotide selection and competitive binding assays to determine the optimal DNA recognition elements for the POU-III and POU-VI protein classes, represented by Brn-2 and Brn-5, respectively.
Expression of the POU transcription factor Brn-5 is an early event in the terminal differentiation of CNS neurons.
Bulleit et al., Baltimore, United States. In J Neurosci Res, 1998
The present study evaluated the temporal and spatial expression pattern of the POU protein Brn-5 in the developing and mature mouse CNS.
Potassium chloride inhibits proliferation of cerebellar granule neuron progenitors.
Bulleit et al., Baltimore, United States. In Brain Res Dev Brain Res, 1998
We also examined the differentiation of granule cell cultures using Brn-5 expression as an early differentiation marker.
POU domain genes are differentially expressed in the early stages after lineage commitment of the PNS-derived stem cell line, RT4-AC.
Reinhart et al., Lubbock, United States. In Brain Res Dev Brain Res, 1998
Brn-4, Brn-5) in the RT4 cell lines.
Expression of the POU transcription factor Brn-5 inhibits proliferation of NG108-15 cells.
Bulleit et al., Baltimore, United States. In Biochem Biophys Res Commun, 1997
The expression of the POU protein Brn-5 occurs selectively in postmitotic CNS neurons.
Identification of novel DNA binding sites recognized by the transcription factor mPOU (POU6F1).
Schäfer et al., Zürich, Switzerland. In Biochem Biophys Res Commun, 1996
Here we identify novel DNA binding sites for the POU protein mPOU (POU6F1).
Chromosomal organization of mammalian POU domain factors.
Lusis et al., Los Angeles, United States. In Genomics, 1993
Chromosomal assignments were made for Brn-1 (Chr 1), Brn-2 (Chr 4), Brn-4 (Chr X), Brn-3.0 (Chr 14), Brn-3.1 (Chr 18), Brn-5.0 (Chr 15), Skn-1a/i (Chr 9), and Sprm-1 (Chr 13) in addition to the previously reported Pit-1 (Chr 16), Tst-1 (Chr 4), Oct-3/4 (Chr 17), Oct-1 (Chr 1), and Oct-2 (Chr 7) genes.
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