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POU domain, class 4, transcription factor 1

Brn-3A, Brn-3
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012] (from NCBI)
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Top mentioned proteins: CAN, Brn-3C, OCT, V1a, ACID
Papers using Brn-3A antibodies
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
Supplier
Huang Eric J. et al., In The Journal of Cell Biology, 2002
... Supernatant was incubated for 1–2 h at 4°C with Brn3a antibody and with protein A/G agarose beads (Santa Cruz Biotechnology, Inc.) overnight at 4°C ...
Papers on Brn-3A
Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model.
New
Joachim et al., Bochum, Germany. In J Mol Neurosci, Feb 2016
At 14 and 28 days, immune-histological and Western blot analyses were performed to investigate the optic nerve structure (SMI-32), retinal ganglion cells (Brn-3a), apoptosis (cleaved caspase 3, FasL), and glial profile (Iba1, ED1, GFAP, vimentin).
Quantitative measurement of retinal ganglion cell populations via histology-based random forest classification.
New
Anderson et al., Iowa City, United States. In Exp Eye Res, Nov 2015
In aged DBA/2J mice with glaucoma, RetFM-Class detected a decrease in median and mean nucleus size of cells classified into the RGC category, as did an independent confirmation study using manual measurements of nuclear area demarcated by BRN3A-immunoreactivity.
Novel features of neurodegeneration in the inner retina of early diabetic rats.
New
Lukáts et al., Budapest, Hungary. In Histol Histopathol, Aug 2015
In contrast to these, most other markers used (calretinin, recoverin, tyrosin hydroxylase anti-Brn-3a and also calbindin in the optic part of the retina) did not show any major alterations in the intensity of immunoreactivity or in the number of stained elements.
S100 alone has the same destructive effect on retinal ganglion cells as in combination with HSP 27 in an autoimmune glaucoma model.
New
Joachim et al., Bochum, Germany. In J Mol Neurosci, May 2015
A significant loss of retinal ganglion cells was also observed in both immunized groups on Brn-3a stained retinal cross-sections (S100, p = 0.003; COMB, p = 0.001).
The Effects of Sonic Hedgehog on Retinal Müller Cells Under High-Glucose Stress.
New
Lu et al., Guangzhou, China. In Invest Ophthalmol Vis Sci, Apr 2015
The effects of exogenous SHH and its inhibitor cyclopamine on retinal ganglion cells (RGCs) survival after 3-month diabetes were examined by the counting of Brn-3a-labeled RGCs.
Actomyosin contractility plays a role in MAP2 expression during nanotopography-directed neuronal differentiation of human embryonic stem cells.
New
Yim et al., Singapore, Singapore. In Biomaterials, Apr 2015
On the other hand, our qPCR array results showed that PAX5, BRN3A and NEUROD1 were highly expressed in hESCs grown on nano-grating substrates as compared to unpatterned substrates, suggesting the possible involvement of these genes in topography-mediated neuronal differentiation of hESCs.
Neuroprotective effects of crocin against oxidative stress induced by ischemia/reperfusion injury in rat retina.
Yang et al., Xi'an, China. In Ophthalmic Res, 2014
The number of retinal ganglion cells (RGCs) was counted by Brn-3a immunofluorescence staining.
Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults.
Heads et al., London, United Kingdom. In Cell Death Dis, 2013
In contrast, the related POU4F1/Brn-3a (Brn-3a) blocks p53-mediated apoptosis but co-operates with p53 to enhance cell cycle arrest.
AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia.
GeneRIF
Gascoyne et al., In Leukemia, 2012
PoU4F1 is highly expressed in t(8;21) samples, with AML/ETO appearning to promote some BRN3A expression
Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.
GeneRIF
Xiang et al., United States. In Dev Biol, 2012
The results demonstrated a critical role for Brn3a in generating dorsal root ganglia sensory neuron diversity and regulating sensory afferent projections to the central targets.
Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse.
GeneRIF
Dhingra et al., India. In J Comp Neurol, 2012
neither Brn3a nor Brn3c are expressed in intrinsically photosensitive retinal ganglion cells
Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.
GeneRIF
Nathans et al., Baltimore, United States. In J Neurosci, 2012
Brn3 gene expression patterns in the retina and inner ear, these experiments suggest a deep functional similarity among primary somatosensory neurons, spiral and vestibular ganglion neurons, and retinal ganglion cells
Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells.
GeneRIF
Roy et al., Benares, India. In J Cancer Res Clin Oncol, 2011
BRN3A possesses anti-apoptotic property, and considering the above results, it may be regarded as the key component in promoting tumorigenic growth in the uterine cervical cells.
[Molecular markers of carcinogenesis in the diagnostics of cervical cancer].
Review
Szmitkowski et al., Poland. In Postepy Hig Med Dosw (online), 2008
This paper is devoted to evaluating the diagnostic usefulness of molecular markers of carcinogenesis, especially P53, Bcl-2, Brn-3a, and MCM, and comparing the results with those of typical tumor markers or cytokines useful in diagnosing this type of cancer.
Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish.
Review
Aizawa et al., Wako, Japan. In Dev Growth Differ, 2008
In this review, we explain how transgenic zebrafish can cast insights into the developmental mechanisms and functional roles of the neural circuits that directly and indirectly control visuomotor behavior, by taking as an example a transgenic line Tg(brn3a-hsp70:GFP) enabling visualization of the tectobulbar and habenulo-interpeduncular tracts.
Brn-3a, a neuronal transcription factor of the POU gene family: indications for its involvement in cancer and angiogenesis.
Review
Magnelli et al., Italy. In Mol Biotechnol, 2002
Brn-3a, a member of the POU gene family (so-called because of the similarity with the group of transcription factors Pit, Oct, and Unc), was found in neuronal cells engaged in the transcription activity of the p1 and p2 promoters of the most powerful antiapoptotic gene, namely, Bcl-2.
POU family transcription factors in the nervous system.
Review
Latchman, London, United Kingdom. In J Cell Physiol, 1999
To exemplify this, studies are described involving the functional characterisation of the Oct-2 factor, one of the original POU factors, and of the Brn-3 factors, which were isolated subsequently and are the mammalian factors most closely related to Unc-86.
The Brn-3a transcription factor.
Review
Latchman, London, United Kingdom. In Int J Biochem Cell Biol, 1998
Brn-3a is a member of the POU family of transcription factors which is expressed predominantly in neuronal cells.
Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons.
Impact
Rosenfeld et al., San Diego, United States. In Nature, 1997
Members of one such family, the class IV POU domain transcription factor Brn-3.0, and two highly related factors Brn-3.1 and Brn-3.2, are differentially expressed in the developing and mature mammalian nervous system.
Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.
Impact
Rosenfeld et al., San Diego, United States. In Nature, 1996
The neurally expressed genes Brn-3.1 and Brn-3.2 (refs 1-6) are mammalian orthologues of the Caenorhabditis elegans unc-86 gene that constitute, with Brn-3.0 (refs 1-3,8,9), the class IV POU-domain transcription factors.
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