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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Breast cancer metastasis suppressor 1

BRMS1, breast cancer metastasis suppressor 1
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Histone, V1a, osteopontin, HAD
Papers on BRMS1
Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration.
New
Šarčević et al., Australia. In Cell Cycle, Feb 2016
Expression of Breast Cancer Metastasis Suppressor 1 (BRMS1) reduces the incidence of metastasis in many human cancers, without affecting tumorigenesis.
In vitro biophysical, microspectroscopic and cytotoxic evaluation of metastatic and non-metastatic cancer cells in responses to anti-cancer drug.
New
Zhou et al., Logan, United States. In Anal Methods, Jan 2016
UNASSIGNED: The Breast Cancer Metastasis Suppressor 1 (BRMS1) is a nucleo-cytoplasmic protein that suppresses cancer metastasis without affecting the growth of the primary tumor.
Cullin3 promotes breast cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation.
New
Yao et al., Xi'an, China. In Oncotarget, Jan 2016
Mechanistically, we found Cullin3 exerts its function through promoting BRMS1 protein degradation, which was associated with EMT, migration and invasion.
Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases.
New
Souchelnytskyi et al., Stockholm, Sweden. In Cancer Metastasis Rev, Dec 2015
BRMS1 was discovered over a decade ago as a potential tumor suppressor gene.
Effect of BRMS1 expression on proliferation, migration and adhesion of mouse forestomach carcinoma.
New
Xu et al., Beijing, China. In Asian Pac J Trop Med, Sep 2015
OBJECTIVE: To discuss the effect of BRMS1 on the proliferation, migration and adhesion of mouse forestomach carcinoma.
Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression.
New
Gao et al., Jinan, China. In Biochem Biophys Res Commun, Sep 2015
Moreover, we also found that the expression of BRMS1 was modulated by JARID1C.
BRMS1 and HPA as Progression, Clinical Biological Behaviors, and Poor Prognosis-related Biomarkers for Gallbladder Adenocarcinoma.
New
Yang et al., Changsha, China. In Appl Immunohistochem Mol Morphol, Aug 2015
PURPOSE: To study the expression of breast cancer metastasis suppressor 1 (BRMS1) and heparanase (HPA) and evaluate their clinicopathologic significance and relationship in benign and malignant lesions of the gallbladder.
Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer.
New
Zhu et al., Hefei, China. In J Biol Chem, Jun 2015
Moreover, we observed that miR-96-182-183 promoted EMT and invasion by directly and simultaneously suppressing BRMS1L (breast cancer metastasis suppressor 1-like) gene expression.
Down-regulation of BRMS1 by DNA hypermethylation and its association with metastatic progression in triple-negative breast cancer.
Yang et al., Qingdao, China. In Int J Clin Exp Pathol, 2014
Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene in several solid tumors.
Breast cancer metastasis suppressor 1 (BRMS1) attenuates TGF-β1-induced breast cancer cell aggressiveness through downregulating HIF-1α expression.
Lee et al., Taejŏn, South Korea. In Bmc Cancer, 2014
Breast cancer metastasis suppressor 1 (BRMS1) is a novel metastasis suppressor protein without anti-proliferating activity.
Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes.
Review
Hurst, Birmingham, United States. In Cancer Metastasis Rev, 2012
Breast cancer metastasis suppressor 1 (BRMS1) interacts with SIN3 chromatin remodeling complexes, and, upon forced expression in metastatic cells, a nearly complete suppression of metastasis is noted without preventing primary tumor growth.
Loss of breast cancer metastasis suppressor 1 promotes ovarian cancer cell metastasis by increasing chemokine receptor 4 expression.
GeneRIF
Liu et al., Guangzhou, China. In Oncol Rep, 2012
Loss of breast cancer metastasis suppressor 1 promotes ovarian cancer cell metastasis by increasing chemokine receptor 4 expression.
Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.
GeneRIF
Welch et al., Birmingham, United States. In Clin Exp Metastasis, 2012
The Brms1 suppressed pulmonary metastasis and promoted apoptosis of tumor cells located in the lungs but not in the mammary glands.
Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex.
GeneRIF
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
These results suggest that the novel regulatory mechanism of BRMS1 by Cul3-SPOP complex is important for breast cancer progression.
Location, location, location: the BRMS1 protein and melanoma progression.
Review
Samant et al., In Bmc Med, 2011
The metastasis suppressor, BRMS1, has been demonstrated to cause dramatic regression of metastatic lesions without blocking orthotopic tumor growth.
Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression.
Review
GeneRIF
Welch et al., Birmingham, United States. In Febs Lett, 2011
the enigmatic complexities of BRMS1-mediated metastasis suppression
[Expression of BRMS1 gene protein in nasal and paranasal sinus carcinomas].
GeneRIF
Zhang et al., Qiqihar, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2011
The loss of BRMS1 expression may be involved in the development and progression of nasal and paranasal sinus carcinomas.
Recent advances in breast cancer metastasis suppressor 1.
Review
Wang et al., Aomen, Macao. In Int J Biol Markers, 2011
Breast cancer metastasis suppressor 1 (BRMS1) was identified as a suppressor of breast cancer metastasis in the late 1990s.
[Progress on breast cancer metastasis suppressor 1 (BRMS1)].
Review
Zhang et al., Beijing, China. In Yi Chuan, 2006
BRMS1 is a tumor metastasis suppressor gene discovered in breast carcinoma cells in 2000.
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