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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, ATPase, Histone, CAN, HAD
Papers using BRG1 antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Copenhaver Gregory P., In PLoS Genetics, 2006
... 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), Santa Cruz Biotechnology, sc-10757; 4) anti-Brg1 (G-7), Santa Cruz Biotechnology, sc-17796; 5) anti-lamin A/C ...
A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis
Cvekl Ales et al., In Epigenetics & Chromatin, 2005
... Brg1) (dnBrg1) transgenic lens ...
Papers on BRG1
Hormone- and DNA Demethylation-Induced Relief of a Tissue-Specific and Developmentally Regulated Block in Transcriptional Elongation.
Wilkinson et al., San Antonio, United States. In J Biol Chem, 20 Nov 2014
Relief of the elongation block is associated with recruitment of the elongation factor P-TEFb, the co-activator GRIP1, the chromatin remodeling factor BRG1, and specific histone modifications.
Rice SNF2 family helicase ENL1 is essential for syncytial endosperm development.
Hattori et al., Nagoya, Japan. In Plant J, 18 Nov 2014
The molecular identification of the causal gene revealed that ENL1 encodes an SNF2 helicase family protein that is orthologous to human PICH, which has been implicated in the resolution of persistent DNA catenation during anaphase.
Novel Mechanism of Negative Regulation of 1,25-Dihydroxyvitamin D3 Induced CYP24A1 Transcription: Epigenetic Modification involving crosstalk between Protein Arginine Methyltransferase 5 and the SWI/SNF Complex.
Christakos et al., United States. In J Biol Chem, 16 Nov 2014
Using SWI/SNF defective cells we demonstrate that BRG1, an ATPase that is a component of the SWI/SNF complex, plays a fundamental role in induction by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the transcription of 25-hydroxyvitamin D 24 hydroxylase (CYP24A1), the enzyme involved in the catabolism of 1,25(OH)2D3.
ATF1 modulates the heat shock response by regulating the stress-inducible HSF1-transcription complex.
Nakai et al., Ube, Japan. In Mol Cell Biol, 13 Nov 2014
The HSF1-transcription complex, including the chromatin-remodeling factor BRG1 and lysine acetyltransferases p300 and CBP, was formed in a manner that was dependent on the phosphorylation of ATF1.
BRG1 overexpression in smooth muscle cells promotes the development of thoracic aortic dissection.
Huang et al., In Bmc Cardiovasc Disord, 11 Nov 2014
BACKGROUND: Here we investigated Brahma-related gene 1 (BRG1) expression in aortic smooth muscle cells (SMCs) and its role in the regulation of the pathological changes in aortic SMCs of thoracic arotic dissection (TAD).
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
Foulkes et al., Montréal, Canada. In Nat Genet, May 2014
Immunohistochemical analysis of these cases and additional familial and non-familial cases showed loss of SMARCA4 (BRG1) protein in 38 of 40 tumors overall.
Remodelling chromatin to shape development of plants.
Hennig et al., Uppsala, Sweden. In Exp Cell Res, Mar 2014
Chromatin remodelling complexes such as the SWI2/SNF2 family of ATP-dependent chromatin remodellers can alter chromatin architecture by changing nucleosome positioning or substituting histones with histone variants.
Rhabdoid tumors: clinical approaches and molecular targets for innovative therapy.
Frühwald et al., Münster, Germany. In Pediatr Hematol Oncol, Oct 2013
Rhabdoid tumors are rare but highly aggressive tumors with a predilection for infants and young children.
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Crabtree et al., Stanford, United States. In Nature, Jun 2013
Several proteins dedicated to this multisubunit complex, including BRG1 (also known as SMARCA4) and BAF250a (also known as ARID1A), are mutated at frequencies similar to those of recognized tumour suppressors.
Non-melanoma skin cancer: carcinogenesis and chemoprevention.
Damian et al., Sydney, Australia. In Pathology, Apr 2013
Many tumour suppressor genes and oncogenes have been studied and implicated in photocarcinogenesis, particularly p53, PTCH1, BRM and RAS.
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4.
Khavari et al., Stanford, United States. In Cell Stem Cell, Mar 2013
Catalytic Brg1 and Brm subunits are required for these processes; however, the roles of SWI/SNF regulatory subunits are not fully understood.
Leukodystrophies with astrocytic dysfunction.
Rodriguez, Paris, France. In Handb Clin Neurol, 2012
The visualization of a white matter cystic breakdown on MRI has led to the identification of CACH/VWM and MLC diseases.
Intracellular regulation of matrix metalloproteinase-2 activity: new strategies in treatment and protection of heart subjected to oxidative stress.
Sawicki, Saskatoon, Canada. In Scientifica (cairo), 2012
One such mechanism involves the proteolytic degradation of contractile proteins, such as troponin I (TnI), myosin heavy chain, titin, and the myosin light chains (MLC1 and MLC2) by matrix metalloproteinase-2 (MMP-2).
Megalencephalic leukoencephalopathy with subcortical cysts: chronic white matter oedema due to a defect in brain ion and water homoeostasis.
Estévez et al., Amsterdam, Netherlands. In Lancet Neurol, 2012
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterised by chronic white matter oedema.
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
Patrick et al., Toledo, United States. In Exp Cell Res, 2012
SWI/SNF chromatin remodeling complex catalytic subunits Brg1 and Brm modulate cisplatin cytotoxicity by facilitating efficient repair of the cisplatin DNA lesions.
Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a meta-analysis.
Suarez-Almazor et al., Houston, United States. In Jama, 2012
Pooled estimates and 95% confidence intervals were calculated for each BRM.
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.
Bultman et al., Chapel Hill, United States. In Circ Res, 2012
Brm functionally compensates for Brg1 in vivo and that there are significant changes in the relative importance of BRG1- and BRM-catalyzed SWI/SNF complexes during the development of an essential cell lineage.
SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
Georgieva et al., Moscow, Russia. In Nucleic Acids Res, 2012
In the repressed state of the ftz-f1 gene, the Pol II complex is pre-recruited on the promoter; Pol II starts transcription but is paused 1.5 kb downstream of the promoter, with SAYP and Brahma forming a nucleosomal barrier ahead of paused Pol II.
The absence of Brm exacerbates photocarcinogenesis.
Lyons et al., Sydney, Australia. In Exp Dermatol, 2012
The absence of Brm increased skin and ocular photocarcinogenesis in mice.
Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination.
Wegner et al., Erlangen, Germany. In Dev Cell, 2012
Sox10 functions in Schwann cells by recruiting Brg1-conttaining chromatin-remodeling complexes.
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