Mechanism governing a stem cell-generating cis-regulatory element.
Madison, United States. In Proc Natl Acad Sci U S A, Apr 2014
Loss-of-function analyses provided evidence for a mechanism in which a mediator of long-range transcriptional control [LIM domain binding 1 (LDB1)] and a chromatin remodeler [Brahma related gene 1 (BRG1)] synergize through the +9.5 site, conferring expression of GATA-2, which is known to promote the genesis and survival of hematopoietic stem cells.
Remodelling chromatin to shape development of plants.
Uppsala, Sweden. In Exp Cell Res, Mar 2014
Chromatin remodelling complexes such as the SWI2/SNF2 family of ATP-dependent chromatin remodellers can alter chromatin architecture by changing nucleosome positioning or substituting histones with histone variants.