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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

BRG1, SNF2, BRM, SWI2, MLC1
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, ATPase, Histone, CAN, HAD
Papers using BRG1 antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Supplier
Copenhaver Gregory P., In PLoS Genetics, 2006
... 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), Santa Cruz Biotechnology, sc-10757; 4) anti-Brg1 (G-7), Santa Cruz Biotechnology, sc-17796; 5) anti-lamin A/C ...
A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis
Supplier
Cvekl Ales et al., In Epigenetics & Chromatin, 2005
... Brg1) (dnBrg1) transgenic lens ...
Papers on BRG1
Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent chromatin remodeling inhibition.
New
Kohtz et al., Chicago, United States. In Development, 02 Aug 2015
In this report, mass spectrometry shows that the Evf2/DLX1 ribonucleoprotein (RNP) contains SWI/SNF related chromatin-remodelers, Brahma related gene 1 (BRG1, SMARCA4) and Brahma-associated factor (BAF170, SMARCC2) in developing forebrain.
Brahma is required for cell cycle arrest and late muscle gene expression during skeletal myogenesis.
New
Puri et al., Los Angeles, United States. In Embo Rep, 01 Aug 2015
UNASSIGNED: Although the two catalytic subunits of the SWI/SNF chromatin-remodeling complex-Brahma (Brm) and Brg1-are almost invariably co-expressed, their mutually exclusive incorporation into distinct SWI/SNF complexes predicts that Brg1- and Brm-based SWI/SNF complexes execute specific functions.
The Catalytic and Non-catalytic Functions of the Brahma Chromatin-Remodeling Protein Collaborate to Fine-Tune Circadian Transcription in Drosophila.
New
Chiu et al., Davis, United States. In Plos Genet, 31 Jul 2015
Here we have identified the Brahma (Brm) complex as a regulator of the Drosophila clock.
SWI/SNF complex deficiency and mismatch repair protein expression in undifferentiated and dedifferentiated endometrial carcinoma.
New
Crook et al., Perth, Australia. In Pathology, 27 Jul 2015
Therefore we have examined INI1 (SMARCB1), BRG1 (SMARCA4), and BAF250a (ARID1A) immunostaining, and also expression of the DNA mismatch repair (MMR) proteins MLH1, PMS2, MSH2 and MSH6 in 22 UEC, seventeen of which were dedifferentiated.
SMARCA4 (BRG1) Loss of Expression Is a Useful Marker for the Diagnosis of Ovarian Small Cell Carcinoma of the Hypercalcemic Type (Ovarian Rhabdoid Tumor): A Comprehensive Analysis of 116 Rare Gynecologic Tumors, 9 Soft Tissue Tumors, and 9 Melanomas.
New
Croce et al., Caen, France. In Am J Surg Pathol, 19 Jun 2015
However, several authors have shown recently that SCCOHTs are characterized by inactivation of the SMARCA4 gene (encoding the BRG1 protein) resulting in a loss of BRG1 protein expression in IHC.
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.
New
Impact
Kim et al., Boston, United States. In Nature, May 2015
EGFR and BRG1 mutations are genetic biomarkers that predict enhanced sensitivity to TopoII inhibitor in response to EZH2 inhibition.
Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation.
Review
New
Han et al., Taejŏn, South Korea. In Exp Mol Med, Dec 2014
A few recent studies have implicated the Brm/Brg-associated factor (BAF) chromatin-remodeling complex, a mammalian homolog of the yeast Swi/Snf complex, in neuronal structural/functional plasticity and memory formation.
The roles of SNF2/SWI2 nucleosome remodeling enzymes in blood cell differentiation and leukemia.
Review
New
Ekwall et al., Huddinge, Sweden. In Biomed Res Int, Dec 2014
Here, we review the role of sucrose nonfermenting (SNF2) family enzymes in blood cell development.
MLC1 protein: a likely link between leukodystrophies and brain channelopathies.
Review
New
Ambrosini et al., Roma, Italy. In Front Cell Neurosci, Dec 2014
The high expression of MLC1 in brain astrocytes contacting blood vessels and meninges and brain alterations observed in MLC patients have led to hypothesize a role for MLC1 in the regulation of ion and water homeostasis.
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
New
Impact
Foulkes et al., Montréal, Canada. In Nat Genet, May 2014
Immunohistochemical analysis of these cases and additional familial and non-familial cases showed loss of SMARCA4 (BRG1) protein in 38 of 40 tumors overall.
Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation.
Review
Reisman et al., Gainesville, United States. In Front Oncol, 2013
The purpose of this review is to put into perspective the role of mutations versus other mechanisms in the silencing of SWI/SNF subunits, in particular, BRG1 and BRM.
GlialCAM, a glial cell adhesion molecule implicated in neurological disease.
Review
Estévez et al., In Adv Neurobiol, 2013
GlialCAM acts a regulator of subcellular traffic of MLC1, a protein with unknown function involved in the pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare neurological condition.
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Impact
Crabtree et al., Stanford, United States. In Nature, 2013
Several proteins dedicated to this multisubunit complex, including BRG1 (also known as SMARCA4) and BAF250a (also known as ARID1A), are mutated at frequencies similar to those of recognized tumour suppressors.
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4.
Impact
Khavari et al., Stanford, United States. In Cell Stem Cell, 2013
Catalytic Brg1 and Brm subunits are required for these processes; however, the roles of SWI/SNF regulatory subunits are not fully understood.
Megalencephalic leukoencephalopathy with subcortical cysts: chronic white matter oedema due to a defect in brain ion and water homoeostasis.
Review
Impact
Estévez et al., Amsterdam, Netherlands. In Lancet Neurol, 2012
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterised by chronic white matter oedema.
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
GeneRIF
Patrick et al., Toledo, United States. In Exp Cell Res, 2012
SWI/SNF chromatin remodeling complex catalytic subunits Brg1 and Brm modulate cisplatin cytotoxicity by facilitating efficient repair of the cisplatin DNA lesions.
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.
GeneRIF
Bultman et al., Chapel Hill, United States. In Circ Res, 2012
Brm functionally compensates for Brg1 in vivo and that there are significant changes in the relative importance of BRG1- and BRM-catalyzed SWI/SNF complexes during the development of an essential cell lineage.
SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
GeneRIF
Georgieva et al., Moscow, Russia. In Nucleic Acids Res, 2012
In the repressed state of the ftz-f1 gene, the Pol II complex is pre-recruited on the promoter; Pol II starts transcription but is paused 1.5 kb downstream of the promoter, with SAYP and Brahma forming a nucleosomal barrier ahead of paused Pol II.
The absence of Brm exacerbates photocarcinogenesis.
GeneRIF
Lyons et al., Sydney, Australia. In Exp Dermatol, 2012
The absence of Brm increased skin and ocular photocarcinogenesis in mice.
Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination.
GeneRIF
Wegner et al., Erlangen, Germany. In Dev Cell, 2012
Sox10 functions in Schwann cells by recruiting Brg1-conttaining chromatin-remodeling complexes.
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