GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
BRG1, SNF2, BRM, SWI2, MLC1
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
BRG1
antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Supplier
In PLoS Genetics, 2006
... 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), Santa Cruz Biotechnology, sc-10757; 4) anti-Brg1 (G-7), Santa Cruz Biotechnology, sc-17796; 5) anti-lamin A/C ...
A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis
Supplier
In Epigenetics & Chromatin, 2005
... Brg1) (dnBrg1) transgenic lens ...
Papers on
BRG1
BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development.
New
Oklahoma City, United States. In Development, 31 Mar 2013
We now report that the chromatin-remodeling enzyme BRG1 promotes COUP-TFII expression in venous endothelial cells during murine embryonic development.
Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
New
Israel. In Dev Cell, 25 Mar 2013
We identify the SWI/SNF chromatin remodeling ATPase BRAHMA (BRM) as a genetic mediator of CIN-TCP activities and CK responses.
BRG1 is required for formation of senescence-associated heterochromatin foci (SAHF) induced by oncogenic RAS or BRCA1 loss.
New
Philadelphia, United States. In Mol Cell Biol, 25 Mar 2013
BRG1 is a chromatin-remodeling factor that interacts with BRCA1 and pRB.
The novel arsenical darinaparsin circumvents BRG1-dependant, HO-1-mediated cytoprotection in leukemic cells.
New
Montréal, Canada. In Leukemia, 21 Mar 2013
Dar treatment prevents recruitment of the transcriptional co-regulator BRG1 to the HMOX1 promoter, which is required for HMOX1 expression.
(1)H, (13)C and (15)N resonance assignments of an N-terminal domain of CHD4.
New
Sydney, Australia. In Biomol Nmr Assign, 17 Mar 2013
Chromodomain helicase DNA-binding protein 4 (CHD4), the defining subunit of the nucleosome remodeling and deacetylase (NuRD) complex, is a nucleosome-remodeling protein of the SNF2/ISWI2 family, members of which contain two chromo domains and an ATP-dependent helicase module.
Structure, function and regulation of CSB: A multi-talented gymnast.
New
Philadelphia, United States. In Mech Ageing Dev, 16 Mar 2013
CSB belongs to the SNF2/SWI2 ATP-dependent chromatin remodeling protein family, and studies from many laboratories have revealed that CSB has multiple activities and modes of regulation.
ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4.
New
Impact
Stanford, United States. In Cell Stem Cell, 07 Mar 2013
Catalytic Brg1 and Brm subunits are required for these processes; however, the roles of SWI/SNF regulatory subunits are not fully understood.
BAF60 A, B, and Cs of muscle determination and renewal.
Review
New
Los Angeles, United States. In Genes Dev, Jan 2013
A key component of the code appears to be the mutually exclusive usage of the a, b, and c variants of the 60-kD structural subunit BAF60 (BRG1/BRM-associated factor 60), of which BAF60c is essential to activate both skeletal and cardiac muscle programs.
Megalencephalic leukoencephalopathy with subcortical cysts: chronic white matter oedema due to a defect in brain ion and water homoeostasis.
Review
New
Impact
Amsterdam, Netherlands. In Lancet Neurol, Nov 2012
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterised by chronic white matter oedema.
Targeting SMARCAL1 as a novel strategy for cancer therapy.
Review
New
Shanghai, China. In Biochem Biophys Res Commun, Nov 2012
SMARCAL1 is a SNF2 chromatin-remodeling protein with ATP-dependent annealing helicase activity.
Massive transfusion: an overview of the main characteristics and potential risks associated with substances used for correction of a coagulopathy.
Review
New
London, United Kingdom. In Transfus Apher Sci, Oct 2012
In brief, the coagulopathy in MT is a complex phenomenon, often complicated by chronic activation of coagulation, platelets, complement and vascular endothelial cells, where haemolysis, microvesiculation, exposure of phosphatidyl serine positive cells, altered red cells with reduced adhesive proteins and the presence of some BRM, could play a pivotal role in the coagulopathy and untoward effects.
Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a meta-analysis.
New
Impact
Houston, United States. In Jama, Oct 2012
Pooled estimates and 95% confidence intervals were calculated for each BRM.
Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration.
Review
New
Durham, United States. In Mol Aspects Med, Aug 2012
(2) RPE cells are subsequently stimulated to increase synthesis of MMPs and other molecules responsible for extracellular matrix turnover (i.e., producing decreased collagen), affecting both RPE basement membrane and Bruchs membrane (BrM).
ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers.
GeneRIF
Baltimore, United States. In Cancer Res, 2011
ARID1A interacts with BRG1 ATPase to form a SWI/SNF chromatin remodeling protein complex which interacts directly with p53 & then binds to CDKN1A & SMAD3 promoters.
Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1.
GeneRIF
Bethesda, United States. In Genome Res, 2011
We show that the catalytic subunit BRG1 of BAF complexes localizes to GATA1-bound distal sites during differentiation and generates a longer nucleosome linker region surrounding the GATA1 sites by shifting the flanking nucleosomes away
Snf2-family proteins: chromatin remodellers for any occasion.
GeneRIF
Dundee, United Kingdom. In Curr Opin Chem Biol, 2011
Snf2 proteins are directly involved in DNA repair. (Review)
NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus.
GeneRIF
United States. In Mol Immunol, 2011
these findings suggest CNSa is a distal enhancer of the IL-3/GM-CSF gene cluster that binds BRG1 and NF-kappaB
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function.
Impact
GeneRIF
Stanford, United States. In Nat Cell Biol, 2011
Brg1 is required to establish chromatin accessibility at STAT3 binding targets, preparing these sites to respond to LIF signalling.
A unique chromatin signature uncovers early developmental enhancers in humans.
Impact
Stanford, United States. In Nature, 2011
Here we show that in human embryonic stem cells (hESCs), unique chromatin signatures identify two distinct classes of genomic elements, both of which are marked by the presence of chromatin regulators p300 and BRG1, monomethylation of histone H3 at lysine 4 (H3K4me1), and low nucleosomal density.
Chromatin regulation by Brg1 underlies heart muscle development and disease.
Impact
GeneRIF
Stanford, United States. In Nature, 2010
Brg1 maintains cardiomyocytes in an embryonic state, and demonstrate an epigenetic mechanism by which three classes of chromatin-modifying factors-Brg1, HDAC and PARP-cooperate to control developmental and pathological gene expression
