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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, ATPase, Histone, CAN, HAD
Papers using BRG1 antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Copenhaver Gregory P., In PLoS Genetics, 2006
... 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), Santa Cruz Biotechnology, sc-10757; 4) anti-Brg1 (G-7), Santa Cruz Biotechnology, sc-17796; 5) anti-lamin A/C ...
A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis
Cvekl Ales et al., In Epigenetics & Chromatin, 2005
... Brg1) (dnBrg1) transgenic lens ...
Papers on BRG1
Extracellular Matrix Alterations and Deposit Formation in AMD.
Garland et al., Boston, United States. In Adv Exp Med Biol, 31 Dec 2015
However, with age and prior to the formation of drusen, extracellular basal deposits accumulate between the retinal pigment epithelium (RPE) and Bruch's membrane (BrM).
Linker histones in hormonal gene regulation.
Beato et al., Barcelona, Spain. In Biochim Biophys Acta, 27 Nov 2015
Similarly, during hormone-dependent gene repression a dedicated enzymatic mechanism controls H1 deposition at promoters by a complex containing HP1γ, LSD1 and BRG1, the ATPase of the BAF complex.
A direct link between abscisic acid sensing and the chromatin remodeling ATPase BRAHMA via core ABA signaling pathway components.
Rodriguez et al., Valencia, Spain. In Mol Plant, 21 Nov 2015
The Arabidopsis SWI/SNF chromatin remodeling ATPase BRAHMA (BRM) modulates response to ABA by preventing premature activation of stress response pathways during germination.
Transcription coupled nucleotide excision repair in the yeast Saccharomyces cerevisiae: The ambiguous role of Rad26.
Li, Baton Rouge, United States. In Dna Repair (amst), 10 Oct 2015
Rad26, a DNA-dependent ATPase in the family of SWI2/SNF2 chromatin remodeling proteins, plays an important role in TC-NER in Saccharomyces cerevisiae.
Loss of ARID1A Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and Clinicopathologic Features.
Lee et al., Ch'ŏnan, South Korea. In J Gastric Cancer, Sep 2015
PURPOSE: The AT-rich interactive domain 1A (ARID1A) gene encodes BRG1-associated factor 250a, a component of the SWItch/Sucrose NonFermentable chromatin remodeling complex, which is considered a tumor suppressor in many tumors.
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.
Kim et al., Boston, United States. In Nature, May 2015
EGFR and BRG1 mutations are genetic biomarkers that predict enhanced sensitivity to TopoII inhibitor in response to EZH2 inhibition.
MLC1 protein: a likely link between leukodystrophies and brain channelopathies.
Ambrosini et al., Roma, Italy. In Front Cell Neurosci, Dec 2014
The high expression of MLC1 in brain astrocytes contacting blood vessels and meninges and brain alterations observed in MLC patients have led to hypothesize a role for MLC1 in the regulation of ion and water homeostasis.
Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation.
Han et al., Taejŏn, South Korea. In Exp Mol Med, Dec 2014
A few recent studies have implicated the Brm/Brg-associated factor (BAF) chromatin-remodeling complex, a mammalian homolog of the yeast Swi/Snf complex, in neuronal structural/functional plasticity and memory formation.
The roles of SNF2/SWI2 nucleosome remodeling enzymes in blood cell differentiation and leukemia.
Ekwall et al., Huddinge, Sweden. In Biomed Res Int, Dec 2014
Here, we review the role of sucrose nonfermenting (SNF2) family enzymes in blood cell development.
Drosophila domino Exhibits Genetic Interactions with a Wide Spectrum of Chromatin Protein-Encoding Loci.
Yedvobnick et al., Atlanta, United States. In Plos One, Dec 2014
UNASSIGNED: The Drosophila domino gene encodes protein of the SWI2/SNF2 family that has widespread roles in transcription, replication, recombination and DNA repair.
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
Foulkes et al., Montréal, Canada. In Nat Genet, May 2014
Immunohistochemical analysis of these cases and additional familial and non-familial cases showed loss of SMARCA4 (BRG1) protein in 38 of 40 tumors overall.
Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation.
Reisman et al., Gainesville, United States. In Front Oncol, 2013
The purpose of this review is to put into perspective the role of mutations versus other mechanisms in the silencing of SWI/SNF subunits, in particular, BRG1 and BRM.
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Crabtree et al., Stanford, United States. In Nature, 2013
Several proteins dedicated to this multisubunit complex, including BRG1 (also known as SMARCA4) and BAF250a (also known as ARID1A), are mutated at frequencies similar to those of recognized tumour suppressors.
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4.
Khavari et al., Stanford, United States. In Cell Stem Cell, 2013
Catalytic Brg1 and Brm subunits are required for these processes; however, the roles of SWI/SNF regulatory subunits are not fully understood.
Megalencephalic leukoencephalopathy with subcortical cysts: chronic white matter oedema due to a defect in brain ion and water homoeostasis.
Estévez et al., Amsterdam, Netherlands. In Lancet Neurol, 2012
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterised by chronic white matter oedema.
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
Patrick et al., Toledo, United States. In Exp Cell Res, 2012
SWI/SNF chromatin remodeling complex catalytic subunits Brg1 and Brm modulate cisplatin cytotoxicity by facilitating efficient repair of the cisplatin DNA lesions.
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.
Bultman et al., Chapel Hill, United States. In Circ Res, 2012
Brm functionally compensates for Brg1 in vivo and that there are significant changes in the relative importance of BRG1- and BRM-catalyzed SWI/SNF complexes during the development of an essential cell lineage.
SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
Georgieva et al., Moscow, Russia. In Nucleic Acids Res, 2012
In the repressed state of the ftz-f1 gene, the Pol II complex is pre-recruited on the promoter; Pol II starts transcription but is paused 1.5 kb downstream of the promoter, with SAYP and Brahma forming a nucleosomal barrier ahead of paused Pol II.
The absence of Brm exacerbates photocarcinogenesis.
Lyons et al., Sydney, Australia. In Exp Dermatol, 2012
The absence of Brm increased skin and ocular photocarcinogenesis in mice.
Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination.
Wegner et al., Erlangen, Germany. In Dev Cell, 2012
Sox10 functions in Schwann cells by recruiting Brg1-conttaining chromatin-remodeling complexes.
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