gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Mar 2015.

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

BRG1, SNF2, BRM, SWI2, MLC1
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, ATPase, Histone, CAN, HAD
Papers using BRG1 antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Supplier
Copenhaver Gregory P., In PLoS Genetics, 2006
... 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), Santa Cruz Biotechnology, sc-10757; 4) anti-Brg1 (G-7), Santa Cruz Biotechnology, sc-17796; 5) anti-lamin A/C ...
A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis
Supplier
Cvekl Ales et al., In Epigenetics & Chromatin, 2005
... Brg1) (dnBrg1) transgenic lens ...
Papers on BRG1
Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells.
New
Davidson et al., Strasbourg, France. In Elife, 24 Apr 2015
We show that MITF interacts with a PBAF chromatin remodelling complex comprising BRG1 and CHD7.
The SWI/SNF ATPases are Required for Triple Negative Breast Cancer Cell Proliferation.
New
Imbalzano et al., Worcester, United States. In J Cell Physiol, 21 Apr 2015
UNASSIGNED: The Brahma (BRM) and Brahma-related Gene 1 (BRG1) ATPases are highly conserved homologues that catalyze the chromatin remodeling functions of the multi-subunit human SWI/SNF chromatin remodeling enzymes in a mutually exclusive manner.
Dynamic Recruitment of Functionally Distinct Swi/Snf Chromatin Remodeling Complexes Modulates Pdx1 Activity in Islet β Cells.
New
Stein et al., Nashville, United States. In Cell Rep, 17 Apr 2015
The two mutually exclusive and indispensable Swi/Snf core ATPase subunits, Brg1 and Brm, distinctly affected target gene expression in β cells.
Molecular prenatal diagnosis of megalencephalic leukoencephalopathy with subcortical cysts in a child from southwest of Iran.
New
Galehdari et al., Ahvāz, Iran. In Clin Case Rep, 28 Feb 2015
Megalencephalic leukoencephalopathy (MLC) is a rare neurological disorder with an autosomal recessive pattern.
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.
New
Impact
Kim et al., Boston, United States. In Nature, 28 Feb 2015
EGFR and BRG1 mutations are genetic biomarkers that predict enhanced sensitivity to TopoII inhibitor in response to EZH2 inhibition.
Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity.
New
Nakai et al., Ube, Japan. In Nat Commun, Dec 2014
HSF1-SSBP1 complex then enhances their induction by facilitating the recruitment of a chromatin-remodelling factor BRG1, and supports cell survival and the maintenance of mitochondrial membrane potential against proteotoxic stresses.
The Roles of SNF2/SWI2 Nucleosome Remodeling Enzymes in Blood Cell Differentiation and Leukemia.
Review
New
Ekwall et al., Huddinge, Sweden. In Biomed Res Int, Dec 2014
UNASSIGNED: Here, we review the role of sucrose nonfermenting (SNF2) family enzymes in blood cell development.
High-grade lung adenocarcinomas with micropapillary and/or solid patterns: a review.
Review
New
Mino-Kenudson et al., Boston, United States. In Curr Opin Pulm Med, Jul 2014
The possible role of molecular events such as loss of BRG1/BRM and activation of c-Met has been identified in solid pattern and micropapillary pattern, respectively.
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
New
Impact
Foulkes et al., Montréal, Canada. In Nat Genet, May 2014
Immunohistochemical analysis of these cases and additional familial and non-familial cases showed loss of SMARCA4 (BRG1) protein in 38 of 40 tumors overall.
The H3K27me3 demethylase UTX in normal development and disease.
Review
New
Van Vlierberghe et al., Gent, Belgium. In Epigenetics, May 2014
In addition, an H3K27me2/3 demethylase independent function for UTX was uncovered in promoting general chromatin remodeling in concert with the BRG1-containing SWI/SNF remodeling complex.
Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation.
Review
Reisman et al., Gainesville, United States. In Front Oncol, 2013
The purpose of this review is to put into perspective the role of mutations versus other mechanisms in the silencing of SWI/SNF subunits, in particular, BRG1 and BRM.
GlialCAM, a glial cell adhesion molecule implicated in neurological disease.
Review
Estévez et al., In Adv Neurobiol, 2013
GlialCAM acts a regulator of subcellular traffic of MLC1, a protein with unknown function involved in the pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare neurological condition.
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Impact
Crabtree et al., Stanford, United States. In Nature, 2013
Several proteins dedicated to this multisubunit complex, including BRG1 (also known as SMARCA4) and BAF250a (also known as ARID1A), are mutated at frequencies similar to those of recognized tumour suppressors.
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4.
Impact
Khavari et al., Stanford, United States. In Cell Stem Cell, 2013
Catalytic Brg1 and Brm subunits are required for these processes; however, the roles of SWI/SNF regulatory subunits are not fully understood.
Megalencephalic leukoencephalopathy with subcortical cysts: chronic white matter oedema due to a defect in brain ion and water homoeostasis.
Review
Impact
Estévez et al., Amsterdam, Netherlands. In Lancet Neurol, 2012
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterised by chronic white matter oedema.
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
GeneRIF
Patrick et al., Toledo, United States. In Exp Cell Res, 2012
SWI/SNF chromatin remodeling complex catalytic subunits Brg1 and Brm modulate cisplatin cytotoxicity by facilitating efficient repair of the cisplatin DNA lesions.
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.
GeneRIF
Bultman et al., Chapel Hill, United States. In Circ Res, 2012
Brm functionally compensates for Brg1 in vivo and that there are significant changes in the relative importance of BRG1- and BRM-catalyzed SWI/SNF complexes during the development of an essential cell lineage.
SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
GeneRIF
Georgieva et al., Moscow, Russia. In Nucleic Acids Res, 2012
In the repressed state of the ftz-f1 gene, the Pol II complex is pre-recruited on the promoter; Pol II starts transcription but is paused 1.5 kb downstream of the promoter, with SAYP and Brahma forming a nucleosomal barrier ahead of paused Pol II.
The absence of Brm exacerbates photocarcinogenesis.
GeneRIF
Lyons et al., Sydney, Australia. In Exp Dermatol, 2012
The absence of Brm increased skin and ocular photocarcinogenesis in mice.
Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination.
GeneRIF
Wegner et al., Erlangen, Germany. In Dev Cell, 2012
Sox10 functions in Schwann cells by recruiting Brg1-conttaining chromatin-remodeling complexes.
share on facebooktweetadd +1mail to friends