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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

BRG1, SNF2, BRM, SWI2, MLC1
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, ATPase, Histone, CAN, POLYMERASE
Papers using BRG1 antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Supplier
Copenhaver Gregory P., In PLoS Genetics, 2006
... 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), Santa Cruz Biotechnology, sc-10757; 4) anti-Brg1 (G-7), Santa Cruz Biotechnology, sc-17796; 5) anti-lamin A/C ...
A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis
Supplier
Cvekl Ales et al., In Epigenetics & Chromatin, 2005
... Brg1) (dnBrg1) transgenic lens ...
Papers on BRG1
Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.
Review
New
Chi et al., Boston, United States. In Neuro Oncol, Feb 2016
The majority of AT/RTs demonstrate genomic alterations in SMARCB1 (INI1, SNF5, BAF47) or, to a lesser extent, SMARCA4 (BRG1) of the SWItch/sucrose nonfermentable chromatin remodeling complex.
FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
New
Impact
Blelloch et al., San Francisco, United States. In Cell Stem Cell, Feb 2016
It recruited the SWI/SNF chromatin remodeling complex ATPase BRG1 to promote nucleosome removal while concurrently inhibiting maximal activation of the same enhancers by recruiting histone deacetylases1/2.
SMARCA4/BRG1 is a novel prognostic biomarker predictive of cisplatin-based chemotherapy outcomes in resected non-small cell lung cancer.
New
Chakravarti et al., Vũng Tàu, Vietnam. In Clin Cancer Res, Jan 2016
We hypothesized that decreased expression of SMARCA4/BRG1, a known regulator of transcription and DNA repair, is a novel predictive biomarker of increased sensitivity to adjuvant platinum-based therapies in NSCLC.
Transcription coupled nucleotide excision repair in the yeast Saccharomyces cerevisiae: The ambiguous role of Rad26.
Review
New
Li, Baton Rouge, United States. In Dna Repair (amst), Dec 2015
Rad26, a DNA-dependent ATPase in the family of SWI2/SNF2 chromatin remodeling proteins, plays an important role in TC-NER in Saccharomyces cerevisiae.
Extracellular Matrix Alterations and Deposit Formation in AMD.
Review
New
Garland et al., Boston, United States. In Adv Exp Med Biol, Dec 2015
However, with age and prior to the formation of drusen, extracellular basal deposits accumulate between the retinal pigment epithelium (RPE) and Bruch's membrane (BrM).
A Mutation in Plant-Specific SWI2/SNF2-Like Chromatin-Remodeling Proteins, DRD1 and DDM1, Delays Leaf Senescence in Arabidopsis thaliana.
New
Kim et al., South Korea. In Plos One, Dec 2015
Therefore, we chose to examine the functions of DRD1, a SWI2/SNF2 chromatin remodeling protein, in epigenetic regulation of leaf senescence, particularly because drd1-6 mutants exhibited a delayed leaf senescence phenotype.
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.
New
Müller et al., Oxford, United Kingdom. In Sci Adv, Nov 2015
BAF complexes contain an ATP (adenosine 5'-triphosphate)-driven remodeling enzyme (either BRG1 or BRM) and multiple protein interaction domains including bromodomains, an evolutionary conserved acetyl lysine-dependent protein interaction motif that recruits transcriptional regulators to acetylated chromatin.
Linker histones in hormonal gene regulation.
Review
New
Beato et al., Spain. In Biochim Biophys Acta, Nov 2015
Similarly, during hormone-dependent gene repression a dedicated enzymatic mechanism controls H1 deposition at promoters by a complex containing HP1γ, LSD1 and BRG1, the ATPase of the BAF complex.
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.
New
Impact
Kim et al., Boston, United States. In Nature, May 2015
EGFR and BRG1 mutations are genetic biomarkers that predict enhanced sensitivity to TopoII inhibitor in response to EZH2 inhibition.
Restoration of BRG1 inhibits proliferation and metastasis of lung cancer by regulating tumor suppressor miR-148b.
Fa et al., Zhengzhou, China. In Onco Targets Ther, 2014
BACKGROUND: Brahma-related gene 1 (BRG1) has been implicated in a variety of biological processes, and it has been found to be mutated or silenced in numerous cancers, including lung cancer.
MLC1 protein: a likely link between leukodystrophies and brain channelopathies.
Review
Ambrosini et al., Roma, Italy. In Front Cell Neurosci, 2014
The high expression of MLC1 in brain astrocytes contacting blood vessels and meninges and brain alterations observed in MLC patients have led to hypothesize a role for MLC1 in the regulation of ion and water homeostasis.
Genome-wide transcriptome analyses of developing seeds from low and normal phytic acid soybean lines.
Maroof et al., Blacksburg, United States. In Bmc Genomics, 2014
Eighteen biological processes such as apoptosis, glucan metabolism, cellular transport, photosynthesis and 9 transcription factor families including WRKY, CAMTA3 and SNF2 were enriched during seed development.
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
Impact
Foulkes et al., Montréal, Canada. In Nat Genet, 2014
Immunohistochemical analysis of these cases and additional familial and non-familial cases showed loss of SMARCA4 (BRG1) protein in 38 of 40 tumors overall.
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Impact
Crabtree et al., Stanford, United States. In Nature, 2013
Several proteins dedicated to this multisubunit complex, including BRG1 (also known as SMARCA4) and BAF250a (also known as ARID1A), are mutated at frequencies similar to those of recognized tumour suppressors.
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4.
Impact
Khavari et al., Stanford, United States. In Cell Stem Cell, 2013
Catalytic Brg1 and Brm subunits are required for these processes; however, the roles of SWI/SNF regulatory subunits are not fully understood.
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
GeneRIF
Patrick et al., Toledo, United States. In Exp Cell Res, 2012
SWI/SNF chromatin remodeling complex catalytic subunits Brg1 and Brm modulate cisplatin cytotoxicity by facilitating efficient repair of the cisplatin DNA lesions.
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.
GeneRIF
Bultman et al., Chapel Hill, United States. In Circ Res, 2012
Brm functionally compensates for Brg1 in vivo and that there are significant changes in the relative importance of BRG1- and BRM-catalyzed SWI/SNF complexes during the development of an essential cell lineage.
SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
GeneRIF
Georgieva et al., Moscow, Russia. In Nucleic Acids Res, 2012
In the repressed state of the ftz-f1 gene, the Pol II complex is pre-recruited on the promoter; Pol II starts transcription but is paused 1.5 kb downstream of the promoter, with SAYP and Brahma forming a nucleosomal barrier ahead of paused Pol II.
The absence of Brm exacerbates photocarcinogenesis.
GeneRIF
Lyons et al., Sydney, Australia. In Exp Dermatol, 2012
The absence of Brm increased skin and ocular photocarcinogenesis in mice.
Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination.
GeneRIF
Wegner et al., Erlangen, Germany. In Dev Cell, 2012
Sox10 functions in Schwann cells by recruiting Brg1-conttaining chromatin-remodeling complexes.
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