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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

BRG1, SNF2, BRM, SWI2, MLC1
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, ATPase, Histone, CAN, HAD
Papers using BRG1 antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Supplier
Copenhaver Gregory P., In PLoS Genetics, 2006
... 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), Santa Cruz Biotechnology, sc-10757; 4) anti-Brg1 (G-7), Santa Cruz Biotechnology, sc-17796; 5) anti-lamin A/C ...
A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis
Supplier
Cvekl Ales et al., In Epigenetics & Chromatin, 2005
... Brg1) (dnBrg1) transgenic lens ...
Papers on BRG1
The H3K27me3 demethylase UTX in normal development and disease.
Review
New
Van Vlierberghe et al., Gent, Belgium. In Epigenetics, Jun 2014
In addition, an H3K27me2/3 demethylase independent function for UTX was uncovered in promoting general chromatin remodeling in concert with the BRG1-containing SWI/SNF remodeling complex.
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
New
Impact
Foulkes et al., Montréal, Canada. In Nat Genet, May 2014
Immunohistochemical analysis of these cases and additional familial and non-familial cases showed loss of SMARCA4 (BRG1) protein in 38 of 40 tumors overall.
Mechanism governing a stem cell-generating cis-regulatory element.
New
Bresnick et al., Madison, United States. In Proc Natl Acad Sci U S A, Apr 2014
Loss-of-function analyses provided evidence for a mechanism in which a mediator of long-range transcriptional control [LIM domain binding 1 (LDB1)] and a chromatin remodeler [Brahma related gene 1 (BRG1)] synergize through the +9.5 site, conferring expression of GATA-2, which is known to promote the genesis and survival of hematopoietic stem cells.
Remodelling chromatin to shape development of plants.
Review
New
Hennig et al., Uppsala, Sweden. In Exp Cell Res, Mar 2014
Chromatin remodelling complexes such as the SWI2/SNF2 family of ATP-dependent chromatin remodellers can alter chromatin architecture by changing nucleosome positioning or substituting histones with histone variants.
The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages.
New
Wang et al., Singapore, Singapore. In Elife, Dec 2013
Here, we demonstrate that Drosophila SWI/SNF chromatin remodeling Brahma (Brm) complex functions cooperatively with another chromatin remodeling factor, Histone deacetylase 3 (HDAC3) to suppress the formation of ectopic type II neuroblasts.
Over-expression of Arabidopsis AtCHR23 chromatin remodeling ATPase results in increased variability of growth and gene expression.
New
Mlynarova et al., Wageningen, Netherlands. In Bmc Plant Biol, Dec 2013
Chromatin remodeling involving SWI/SNF2-type ATPases is thought to be an important epigenetic mechanism for the regulation of gene expression in different developmental programs and for integrating these programs with the response to environmental signals.
Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
New
Jentsch et al., Berlin, Germany. In Nat Commun, Dec 2013
Defects in the astrocytic membrane protein MLC1, the adhesion molecule GlialCAM or the chloride channel ClC-2 underlie human leukoencephalopathies.
The toxoplasma Acto-MyoA motor complex is important but not essential for gliding motility and host cell invasion.
New
Meissner et al., Glasgow, United Kingdom. In Plos One, Dec 2013
Here the roles of MyoA, MLC1, GAP45 and Act1, core components of the gliding machinery, are re-dissected in detail.
BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
New
Impact
Crabtree et al., Stanford, United States. In Nature, Jun 2013
Several proteins dedicated to this multisubunit complex, including BRG1 (also known as SMARCA4) and BAF250a (also known as ARID1A), are mutated at frequencies similar to those of recognized tumour suppressors.
Non-melanoma skin cancer: carcinogenesis and chemoprevention.
Review
New
Damian et al., Sydney, Australia. In Pathology, Apr 2013
Many tumour suppressor genes and oncogenes have been studied and implicated in photocarcinogenesis, particularly p53, PTCH1, BRM and RAS.
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4.
New
Impact
Khavari et al., Stanford, United States. In Cell Stem Cell, Mar 2013
Catalytic Brg1 and Brm subunits are required for these processes; however, the roles of SWI/SNF regulatory subunits are not fully understood.
Intracellular regulation of matrix metalloproteinase-2 activity: new strategies in treatment and protection of heart subjected to oxidative stress.
Review
Sawicki, Saskatoon, Canada. In Scientifica (cairo), 2012
One such mechanism involves the proteolytic degradation of contractile proteins, such as troponin I (TnI), myosin heavy chain, titin, and the myosin light chains (MLC1 and MLC2) by matrix metalloproteinase-2 (MMP-2).
Leukodystrophies with astrocytic dysfunction.
Review
Rodriguez, Paris, France. In Handb Clin Neurol, 2012
The visualization of a white matter cystic breakdown on MRI has led to the identification of CACH/VWM and MLC diseases.
Megalencephalic leukoencephalopathy with subcortical cysts: chronic white matter oedema due to a defect in brain ion and water homoeostasis.
Review
Impact
Estévez et al., Amsterdam, Netherlands. In Lancet Neurol, 2012
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterised by chronic white matter oedema.
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
GeneRIF
Patrick et al., Toledo, United States. In Exp Cell Res, 2012
SWI/SNF chromatin remodeling complex catalytic subunits Brg1 and Brm modulate cisplatin cytotoxicity by facilitating efficient repair of the cisplatin DNA lesions.
Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a meta-analysis.
Impact
Suarez-Almazor et al., Houston, United States. In Jama, 2012
Pooled estimates and 95% confidence intervals were calculated for each BRM.
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.
GeneRIF
Bultman et al., Chapel Hill, United States. In Circ Res, 2012
Brm functionally compensates for Brg1 in vivo and that there are significant changes in the relative importance of BRG1- and BRM-catalyzed SWI/SNF complexes during the development of an essential cell lineage.
SAYP and Brahma are important for 'repressive' and 'transient' Pol II pausing.
GeneRIF
Georgieva et al., Moscow, Russia. In Nucleic Acids Res, 2012
In the repressed state of the ftz-f1 gene, the Pol II complex is pre-recruited on the promoter; Pol II starts transcription but is paused 1.5 kb downstream of the promoter, with SAYP and Brahma forming a nucleosomal barrier ahead of paused Pol II.
The absence of Brm exacerbates photocarcinogenesis.
GeneRIF
Lyons et al., Sydney, Australia. In Exp Dermatol, 2012
The absence of Brm increased skin and ocular photocarcinogenesis in mice.
Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination.
GeneRIF
Wegner et al., Erlangen, Germany. In Dev Cell, 2012
Sox10 functions in Schwann cells by recruiting Brg1-conttaining chromatin-remodeling complexes.
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