Involvement of TERT in heterochromatin maintenance.
Tokyo, Japan. In Mol Cell Biol, 18 Mar 2014
Here, we describe a complex composed of human TERT (hTERT), Brahma-related gene 1 (BRG1), and nucleostemin (NS) that contributes to heterochromatin maintenance at centromeres and transposons.
Chromatin-regulating proteins as targets for cancer therapy.
Tokyo, Japan. In J Radiat Res (tokyo), 11 Mar 2014
DOT1L inhibition in MLL-rearranged leukemia, EZH2 inhibition in EZH2-mutant or MLL-rearranged hematologic malignancies and SNF5-deficient tumors, BRD4 inhibition in various hematologic malignancies, and BRM inhibition in BRG1-deficient tumors have demonstrated promising anti-tumor effects in preclinical models, and these strategies are currently awaiting clinical application.
BAF60 A, B, and Cs of muscle determination and renewal.
Los Angeles, United States. In Genes Dev, 2013
A key component of the code appears to be the mutually exclusive usage of the a, b, and c variants of the 60-kD structural subunit BAF60 (BRG1/BRM-associated factor 60), of which BAF60c is essential to activate both skeletal and cardiac muscle programs.
A unique chromatin signature uncovers early developmental enhancers in humans.
Stanford, United States. In Nature, 2011
Here we show that in human embryonic stem cells (hESCs), unique chromatin signatures identify two distinct classes of genomic elements, both of which are marked by the presence of chromatin regulators p300 and BRG1, monomethylation of histone H3 at lysine 4 (H3K4me1), and low nucleosomal density.