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BRE1 Bre1p

Bre1, RNF20, hBRE1
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: Histone, Ubiquitin, POLYMERASE, V1a, CAN
Papers on Bre1
Chromatin modification and NBS1: their relationship in DNA double-strand break repair.
Kobayashi et al., Kyoto, Japan. In Genes Genet Syst, Feb 2016
Its recently identified binding partner RNF20 is an E3 ubiquitin ligase that facilitates the monoubiquitination of histone H2B, a process that is crucial for recruitment of the chromatin remodeler SNF2h to DSB damage sites.
The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination.
Wang et al., Shanghai, China. In Embo J, Jan 2016
Using tandem affinity purification and mass spectrometry, we find that MED23 associates with the RNF20/40 complex, the enzyme for H2Bub, and show that this association is critical for the recruitment of RNF20/40 to chromatin.
TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.
Kim et al., Suwŏn, South Korea. In Nat Commun, Dec 2015
Biochemical analysis reveals that the N terminus of TRAIP is crucial for RAP80 interaction, while the C terminus of TRAIP is required for TRAIP localization to sites of DNA damage through a direct interaction with RNF20-RNF40.
Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.
Pandita et al., Dallas, United States. In Mol Cell Biol, Nov 2015
Sec8 perturbation resulted in the accumulation of ATF2 and RNF20 and the promiscuous accumulation of DDR-associated chromatin marks and Rad51 repairosomes.
Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity.
Wolberger et al., Baltimore, United States. In Nucleic Acids Res, Nov 2015
Rad6 is a yeast E2 ubiquitin conjugating enzyme that monoubiquitinates histone H2B in conjunction with the E3, Bre1, but can non-specifically modify histones on its own.
Histone H2B monoubiquitination: roles to play in human malignancy.
Marsh et al., Sydney, Australia. In Endocr Relat Cancer, Feb 2015
The H2Bub1 enzymatic cascade involves E3 RING finger ubiquitin ligases, with the main E3 generally accepted to be the RNF20-RNF40 complex, and deubiquitinases including ubiquitin-specific protease 7 (USP7), USP22 and USP44.
RE-IIBP Methylates H3K79 and Induces MEIS1-mediated Apoptosis via H2BK120 Ubiquitination by RNF20.
Seo et al., Seoul, South Korea. In Sci Rep, 2014
By means of proteomic and biochemical analysis, association of RE-IIBP with the E3 ubiquitin ligase RNF20 was demonstrated for synergistic activation of MEIS1 transcription via H3K79 HMTase activity.
RNF20-SNF2H Pathway of Chromatin Relaxation in DNA Double-Strand Break Repair.
Komatsu et al., Kyoto, Japan. In Genes (basel), 2014
The ubiquitylation of histone H2B by RNF20 E3 ligase was recently found to be a DNA damage-induced histone modification.
Functional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis.
Komatsu et al., Kyoto, Japan. In Biomolecules, 2014
Moreover, NBS1 regulates chromatin remodeling during DSB repair by histone H2B ubiquitination through binding to RNF20 at the C-terminus.
Writing and reading H2B monoubiquitylation.
Oren et al., Israel. In Biochim Biophys Acta, 2014
Monoubiquitylation of histone H2B (H2Bub1), catalyzed by the heterodimeric ubiquitin ligase complex RNF20/40, regulates multiple molecular and biological processes.
Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.
Brown et al., Stanford, United States. In Cancer Res, 2012
We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability
Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.
Palvimo et al., Kuopio, Finland. In Mol Cell Endocrinol, 2012
our results suggest that RNF20 and RNF40, either via ubiquitylation of H2B or other targets, are coupled to the proliferation of prostate cancer cells.
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.
Zhang et al., Bethesda, United States. In Nat Med, 2012
We show that Smurf2 regulates the monoubiquitination of histone H2B as well as the trimethylation of histone H3 at Lys4 and Lys79 by targeting ring finger protein 20 (RNF20) for proteasomal degradation in both mouse and human cells.
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.
Shilatifard, Kansas City, United States. In Annu Rev Biochem, 2011
In yeast, the histone H2B monoubiquitinase Rad6/Bre1 is required for proper H3K4 and H3K79 trimethylations.
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression.
Enserink et al., Oslo, Norway. In Proc Natl Acad Sci U S A, 2011
DOA1 is important for cell cycle entry by supplying ubiquitin, and the RAD6-BRE1 pathway functions downstream of DOA1/ubiquitin but upstream of CDC28, by promoting transcription of cyclins
RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.
Oren et al., Tel Aviv-Yafo, Israel. In Febs Lett, 2011
Studies indicate that H2B monoubiquitylation is driven primarily by an E3 ubiquitin ligase composed of the two RING finger proteins RNF20 and RNF40.
Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination.
Dent et al., Anderson, United States. In Cell, 2011
Deletion of RAD6, BRE1, or Paf1 complex members abolishes Dam1 methylation, as does mutation of H2BK123.
RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.
Oren et al., Israel. In Mol Cell, 2011
RNF20, presumably via H2Bub, selectively represses oncogenic genes by interfering with chromatin recruitment of TFIIS, a factor capable of relieving stalled RNA polymerase II. RNF20 inhibits the interaction between TFIIS and the PAF1 complex.
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.
Roeder et al., New York City, United States. In Cell, 2009
Beyond earlier identification of hBRE1 as the E3 ligase for H2B ubiquitylation in human cells, we now show (1) that hRAD6 serves as the cognate E2-conjugating enzyme; (2) that hRAD6, through direct interaction with hPAF-bound hBRE1, is recruited to transcribed genes and ubiquitylates chromatinized H2B at lysine 120; (3) that hPAF-mediated transcription is required for efficient H2B ubiquitylation as a result of hPAF-dependent recruitment of hBRE1-hRAD6 to the Pol II transcription machinery; (4) that H2B ubiquitylation per se does not affect the level of hPAF-, SII-, and p300-dependent transcription and likely functions downstream; and (5) that H2B ubiquitylation directly stimulates hSET1-dependent H3K4 di- and trimethylation.
Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.
Dargemont et al., Paris, France. In Nat Cell Biol, 2008
We found that Rad6/Bre1 ubiquitylation enzymes responsible for H2B ubiquitylation also participate directly in Swd2 modification.
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