Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.
Miami, United States. In J Neurosci, Dec 2015
Members of the bromodomain and extraterminal (BET) family of epigenetic "reader" proteins (BRD2, BRD3, BRD4, and BRDT) bind acetylated histones and serve as a scaffold for the recruitment of macromolecular complexes to modify chromatin accessibility and transcriptional activity.
BET bromodomain inhibitors: a patent review.
Australia. In Expert Opin Ther Pat, 2014
INTRODUCTION: The bromodomain (BRD) and extra-C terminal domain (BET) protein family consists of four members (BRD2, BRD3, BRD4 and BRDT).
Bromodomains as therapeutic targets in cancer.
Cambridge, United States. In Brief Funct Genomics, 2013
Small molecules with high specificity for the Bromodomain and Extra Terminal family of proteins (BRD2, BRD3, BRD4 and BRDT) have recently been shown to have remarkable pre-clinical efficacy in various malignancies.