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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Bromodomain, testis-specific

BRDT, CT9
BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: BET, Histone, BRD3, BRD1, CAN
Papers on BRDT
Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IκB kinase-dependent NF-κB activation in rheumatoid fibroblast-like synoviocytes.
New
Xu et al., Guangzhou, China. In Rheumatology (oxford), Jan 2016
RESULTS: Four Brd proteins, including Brd2, Brd3, Brd4 and Brdt, were expressed in FLSs from patients with RA and OA; however, the expression of Brd2 and Brd4 was increased in RA compared with that in OA.
BET Protein BRDT Complexes with HDAC1, PRMT5 and TRIM28 and Functions in Transcriptional Repression During Spermatogenesis.
New
Wolgemuth et al., New York City, United States. In J Cell Biochem, Dec 2015
UNASSIGNED: The expression of BRDT, a member of the BET sub-family of double bromodomain-containing proteins, is restricted to the male germ line, specifically to pachytene-diplotene spermatocytes and early spermatids.
Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.
New
Wahlestedt et al., Miami, United States. In J Neurosci, Dec 2015
Members of the bromodomain and extraterminal (BET) family of epigenetic "reader" proteins (BRD2, BRD3, BRD4, and BRDT) bind acetylated histones and serve as a scaffold for the recruitment of macromolecular complexes to modify chromatin accessibility and transcriptional activity.
Planned FDG PET-CT Scan in Follow-Up Detects Disease Progression in Patients With Locally Advanced NSCLC Receiving Curative Chemoradiotherapy Earlier Than Standard CT.
New
Hansen et al., Guangzhou, China. In Medicine (baltimore), Oct 2015
All patients had a PET-CT scan scheduled 9 months (PET-CT9) after the start of the radiation treatment in addition to standard follow-up (group A).
Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception.
Review
New
Szten et al., Wrocław, Poland. In Adv Clin Exp Med, Jul 2015
Another promising method acts by blocking Bromodomain testis-specific proteins (Brdt) involved in the process of spermatogenesis.
Characterization of BRD4 during mammalian postmeiotic sperm development.
New
Berger et al., Philadelphia, United States. In Mol Cell Biol, Apr 2015
Although BRDT functions in transcription and histone removal in spermatids, it is unknown whether other BET family proteins play a role.
Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery.
Review
New
Liu et al., Chengdu, China. In Oncotarget, Apr 2015
Proteins that share the feature of containing two BRDs and an extra-terminal domain belong to BET family, including BRD2, BRD3, BRD4 and BRDT.
Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes.
New
Loppin et al., Villeurbanne, France. In Open Biol, Feb 2015
In mammals, the testis-specific bromodomain and extra terminal (BET) protein BRDT is essential for spermatogenesis.
Attenuation of vesicular stomatitis virus infection of brain using antiviral drugs and an adeno-associated virus-interferon vector.
New
van den Pol et al., New Haven, United States. In Virology, Feb 2015
We compared 12 antiviral compounds to control infection of VSV-CT9-M51 and VSV-rp30 using murine and human brain cultures, and in vivo mouse models.
Genetic association study of RNF8 and BRDT variants with non-obstructive azoospermia in the Chinese Han population.
Cao et al., China. In Syst Biol Reprod Med, 2015
Ring finger protein 8 (RNF8) and bromodomain testis-specific (BRDT) are two candidate genes associated with spermatogenesis.
BET bromodomain inhibitors: a patent review.
Review
Burns et al., Australia. In Expert Opin Ther Pat, 2014
INTRODUCTION: The bromodomain (BRD) and extra-C terminal domain (BET) protein family consists of four members (BRD2, BRD3, BRD4 and BRDT).
Bromodomains as therapeutic targets in cancer.
Review
Dawson et al., Cambridge, United States. In Brief Funct Genomics, 2013
Small molecules with high specificity for the Bromodomain and Extra Terminal family of proteins (BRD2, BRD3, BRD4 and BRDT) have recently been shown to have remarkable pre-clinical efficacy in various malignancies.
The role of the double bromodomain-containing BET genes during mammalian spermatogenesis.
Review
Wolgemuth et al., New York City, United States. In Curr Top Dev Biol, 2012
The four mammalian BET genes are each expressed at unique times during spermatogenesis, and the testis-specific gene Brdt is essential for spermatogenesis.
Small-molecule inhibition of BRDT for male contraception.
Impact
Bradner et al., Houston, United States. In Cell, 2012
Here, we report potent inhibition of the testis-specific member BRDT, which is essential for chromatin remodeling during spermatogenesis.
Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis.
GeneRIF
Rao et al., Bengaluru, India. In J Biol Chem, 2012
The N terminus of Brdt is involved in the recognition of Smarce1 as well as in the reorganization of hyperacetylated round spermatid chromatin.
Expression of BET genes in testis of men with different spermatogenic impairments.
GeneRIF
Kleiman et al., Ramat Gan, Israel. In Fertil Steril, 2012
In human, BRDT is the only BET gene expressed exclusively in testicular germ cells.
The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background.
GeneRIF
Wolgemuth et al., New York City, United States. In Dev Biol, 2012
the first bromodomain of Brdt is critical in the formation and/or maintenance of an intact chromocenter and implicate this structure in proper remodeling of the chromatin architecture of the sperm head.
The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men.
GeneRIF
Paradowska et al., Gießen, Germany. In Reproduction, 2010
Suggest that reduced histone methylation in the promoter of BRDT may be associated with increased transcript levels in subfertile patients.
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain.
Impact
GeneRIF
Petosa et al., Grenoble, France. In Nature, 2009
a single bromodomain (BD1) of Brdt is responsible for selectively recognizing histone H4 tails bearing two or more acetylation marks
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