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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Signal transducing adaptor family member 1

BRDG1, STAP-1, BCR downstream signaling 1, signal-transducing adaptor protein-1
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on BRDG1
Induction of STAP-1 promotes neurotoxic activation of microglia.
GeneRIF
Langmann et al., Regensburg, Germany. In Biochem Biophys Res Commun, 2009
Taken together, this study implicates a previously unknown role of STAP-1 in pro-inflammatory microglia activation potentially contributing to neuronal apoptosis and degeneration.
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