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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Bromodomain containing 7

BRD7, BP75, Celtix-1
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: BRD1, CAN, Histone, p53, SWI
Papers on BRD7
Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.
Wu et al., Wuhan, China. In Cancer Lett, Mar 2016
On the other hand, hepatoma cell proliferation is attenuated by the bromodomain containing 7 (BRD7), a tumor suppressor, through a negative feedback regulatory mechanism.
Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.
Magnuson et al., San Francisco, United States. In J Med Chem, Jan 2016
More recently, non-BET bromodomain inhibitors that are potent and selective have been disclosed for ATAD2, CBP, BRD7/9, BRPF, BRPF/TRIM24, CECR2, SMARCA4, and BAZ2A/B.
Integrating ChIP-sequencing and digital gene expression profiling to identify BRD7 downstream genes and construct their regulating network.
Zeng et al., Changsha, China. In Mol Cell Biochem, Oct 2015
UNASSIGNED: BRD7 is a single bromodomain-containing protein that functions as a subunit of the SWI/SNF chromatin-remodeling complex to regulate transcription.
MicroRNA-410 promotes cell proliferation by targeting BRD7 in non-small cell lung cancer.
Yang et al., Shijiazhuang, China. In Febs Lett, Sep 2015
In addition, bromodomain-containing protein 7 (BRD7) was a direct target of miR-410.
Inactivation of BRD7 results in impaired cognitive behavior and reduced synaptic plasticity of the medial prefrontal cortex.
Li et al., Changsha, China. In Behav Brain Res, Jul 2015
BRD7 is a bromodomain-containing protein (BCP), and recent evidence implicates the role of BCPs in the initiation and development of neurodevelopmental disorders.
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
Dixon et al., Madison, United States. In Angew Chem Int Ed Engl, Jun 2015
The bromodomain-containing proteins BRD9 and BRD7 are part of the human SWI/SNF chromatin-remodeling complexes BAF and PBAF.
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
Humphreys et al., Cambridge, United Kingdom. In J Med Chem, May 2015
I-BRD9 was identified through structure-based design, leading to greater than 700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7).
Candidate gene analysis of BRCA1/2 mutation-negative high-risk Russian breast cancer patients.
Imyanitov et al., Saint Petersburg, Russia. In Cancer Lett, May 2015
The analysis of genes with yet unproven BC-predisposing significance (BARD1, BRD7, CHEK1, DDB2, ERCC1, EXO1, FANCG, PARP1, PARP2, RAD51, RNF8, WRN) identified single women carrying a protein-truncating allele, WRN R1406X.
BRD7 promoter hypermethylation as an indicator of well differentiated oral squamous cell carcinomas.
Ramanathan et al., India. In Asian Pac J Cancer Prev, 2014
BRD7 is a single bromodomain containing protein that functions as a subunit of SWI/SNF chromatin-remodeling complex to regulate transcription.
Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7.
Ni et al., Harbin, China. In Plos One, 2014
Moreover, we identified that bromodomain-containing protein 7 (BRD7), a new tumor suppressor gene, was a direct target of miR-300.
BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K.
Ozcan et al., Boston, United States. In Cell Metab, 2014
Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family that is known to play a role as tumor suppressors.
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.
Müller et al., Oxford, United Kingdom. In Epigenetics Chromatin, 2013
Significant differences between wild type and bromodomain mutants for ATAD2, BAZ2A, BRD1, BRD7, GCN5L2, SMARCA2 and ZMYND11 required the addition of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) to amplify the binding contribution of the bromodomain.
The interactions between MicroRNA-200c and BRD7 in endometrial carcinoma.
Bae et al., Seoul, South Korea. In Gynecol Oncol, 2012
miR-200c inhibits the expression of BRD7. MiR-200c regulated the translocation of beta-catenin from the cytoplasm to the nucleus via inhibition of BRD7, resulting in increased expression of its transcriptional target genes, cyclinD1 and c-myc.
[Expression and clinical significance of bromodomain-containing protein 7 in non-small cell lung cancer].
Yu et al., Changsha, China. In Zhongguo Fei Ai Za Zhi, 2011
Data indicate that BRD7 may be related to the occurrence, development, and metastasis of lung cancers.
[Definition and function identification of nucleus export signal of BRD7].
Li et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011
The region from aa219 to aa450 is primarily defined as an atypical nuclear export signal in BRD7.
[Transcriptomic regulation and molecular mechanism of polygenic tumor at different stages].
Li et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011
Genes including SPLUNC1, LTF, BRD7, NOR1, BRCA1/2, PALB2, AF1Q, SOX17, NGX6, SOX7, and LRRC4 have been identified as the key transcriptional regulation genes during the stage of tumor initiation and invasion.
Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.
Elledge et al., Boston, United States. In Proc Natl Acad Sci U S A, 2010
as unique regulators of replicative senescence in human cells, both BRD7 and BAF180 regulate p53 transcriptional activity toward a subset of its target genes required for replicative and oncogenic stress senescence induction
[The effect of ATRA-induced leukemic cell differentiation on Brd7 gene expression in leukemia cell lines].
Xiao et al., Changsha, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010
All-trans retinoic acid enhances brd7 gene expression as HL-60 cells differentiate.
BRD7 is a candidate tumour suppressor gene required for p53 function.
Del Sal et al., Amsterdam, Netherlands. In Nat Cell Biol, 2010
BRD7 suppresses tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogene-induced senescence.
[Functional genomics of nasopharyngeal carcinoma susceptibility/suppressor gene].
Li et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2008
The functional research of NPC susceptibility/ suppressor gene candidates indicated: (1) The increased expression of Cx contributed to obstacles of gap junctional intercellular communication (GJIC), and resulted an aberration of GJIC; (2) BRD7, a transcript factor, was associated with cell cycle regulation; (3) NAG7,an estrogen receptor repressor, inhibited the invasive potential of human NPC cells by regulating ERalpha expression and the H-ras/p-c-Raf and JNK/AP-1/MMP1 signaling pathways; (4) NGX6, a metastasis-associated protein, can negative-regulate EGF/Ras/MAPK signaling transduction pathway, and interact with ezrin protein to inhibit invasion and metastasis of NPC cells; (5) SPLUNC1, a secreted protein, can inhibit the bacterium clone formation, and is an innate immune molecule.
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