Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.
San Francisco, United States. In J Med Chem, Jan 2016
More recently, non-BET bromodomain inhibitors that are potent and selective have been disclosed for ATAD2, CBP, BRD7/9, BRPF, BRPF/TRIM24, CECR2, SMARCA4, and BAZ2A/B.
Candidate gene analysis of BRCA1/2 mutation-negative high-risk Russian breast cancer patients.
Saint Petersburg, Russia. In Cancer Lett, May 2015
The analysis of genes with yet unproven BC-predisposing significance (BARD1, BRD7, CHEK1, DDB2, ERCC1, EXO1, FANCG, PARP1, PARP2, RAD51, RNF8, WRN) identified single women carrying a protein-truncating allele, WRN R1406X.
[Transcriptomic regulation and molecular mechanism of polygenic tumor at different stages].
Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011
Genes including SPLUNC1, LTF, BRD7, NOR1, BRCA1/2, PALB2, AF1Q, SOX17, NGX6, SOX7, and LRRC4 have been identified as the key transcriptional regulation genes during the stage of tumor initiation and invasion.
[Functional genomics of nasopharyngeal carcinoma susceptibility/suppressor gene].
Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2008
The functional research of NPC susceptibility/ suppressor gene candidates indicated: (1) The increased expression of Cx contributed to obstacles of gap junctional intercellular communication (GJIC), and resulted an aberration of GJIC; (2) BRD7, a transcript factor, was associated with cell cycle regulation; (3) NAG7,an estrogen receptor repressor, inhibited the invasive potential of human NPC cells by regulating ERalpha expression and the H-ras/p-c-Raf and JNK/AP-1/MMP1 signaling pathways; (4) NGX6, a metastasis-associated protein, can negative-regulate EGF/Ras/MAPK signaling transduction pathway, and interact with ezrin protein to inhibit invasion and metastasis of NPC cells; (5) SPLUNC1, a secreted protein, can inhibit the bacterium clone formation, and is an innate immune molecule.