Expression alterations define unique molecular characteristics of spinal ependymomas.
Nottingham, United Kingdom. In Oncotarget, Sep 2015
In addition, a high number of significantly down-regulated genes in SEPN are localized to chromosome 22 (81 genes from chr22: 43,325,255 - 135,720,974; FDR = 1.77 × 10-23 and 22 genes from chr22: 324,739 - 32,822,302; FDR = 2.07 × 10-09) including BRD1, EP300, HDAC10, HIRA, HIC2, MKL1, and NF2.
Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer.
Xiamen, China. In Biomed Res Int, 2013
Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation.
Bromodomain motifs and "scaffolding"?
Boston, United States. In Front Biosci, 2001
Bromodomain-containing multiprotein complexes share some of the properties of signal transduction scaffolds.