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Bromodomain containing 1

BRD1, Br-L, Bromodomain-containing, bromodomain-containing 1
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, BET, CAN, V1a, SWI
Papers on BRD1
Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer.
Zhang et al., Wuhan, China. In Biochem Biophys Res Commun, Feb 2016
Bromodomain-containing protein 4 (BRD4) is an important member of the bromodomain and extra terminal domain family that influences transcription of downstream genes by binding to acetylated histones.
Bromodomains: Translating the words of lysine acetylation into myelin injury and repair.
Casaccia et al., New York City, United States. In Neurosci Lett, Nov 2015
Bromodomain-containing proteins can have a wide variety of functions, ranging from histone acetyltransferase activity and chromatin remodeling to transcriptional mediation and co-activation.
Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules.
Pomerantz et al., Minneapolis, United States. In Acs Chem Biol, Nov 2015
Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and inflammation.
Expression alterations define unique molecular characteristics of spinal ependymomas.
Grundy et al., Nottingham, United Kingdom. In Oncotarget, Sep 2015
In addition, a high number of significantly down-regulated genes in SEPN are localized to chromosome 22 (81 genes from chr22: 43,325,255 - 135,720,974; FDR = 1.77 × 10-23 and 22 genes from chr22: 324,739 - 32,822,302; FDR = 2.07 × 10-09) including BRD1, EP300, HDAC10, HIRA, HIC2, MKL1, and NF2.
The yeast BDF1 regulates endocytosis via LSP1 under salt stress.
Bao et al., Jinan, China. In Curr Microbiol, May 2015
Bromodomain-containing transcription factor, a kind of important regulating protein, can recognize and bind to acetylated histone.
DNA methylation regulates bromodomain-containing protein 2 expression during adipocyte differentiation.
Yu et al., Shanghai, China. In Mol Cell Biochem, Apr 2015
Bromodomain-containing protein 2 (Brd2), which belongs to the bromodomain and extraterminal domain family of proteins, suppresses adipocyte differentiation.
Biallelic germline and somatic mutations in malignant mesothelioma: multiple mutations in transcription regulators including mSWI/SNF genes.
Hashimoto-Tamaoki et al., Nishinomiya, Japan. In Int J Cancer, Mar 2015
A mono-allelic variant of BRD1 was common to two MM cell lines with very low acetylation levels.
Small molecule inhibitors of bromodomain-acetyl-lysine interactions.
Conway et al., Oxford, United Kingdom. In Acs Chem Biol, Feb 2015
Bromodomain-containing proteins are often found as components of larger protein complexes with roles in fundamental cellular process including transcription.
A Bead-Based Proximity Assay for BRD4 Ligand Discovery.
Bradner et al., Boston, United States. In Curr Protoc Chem Biol, 2014
Bromodomain-containing proteins have emerged as desirable targets for anti-neoplastic and anti-inflammatory drug discovery.
BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos.
You et al., Philadelphia, United States. In Cell Death Differ, 2014
Bromodomain-containing protein 4 (BRD4) is an important epigenetic reader implicated in the pathogenesis of a number of different cancers and other diseases.
BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K.
Ozcan et al., Boston, United States. In Cell Metab, 2014
Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family that is known to play a role as tumor suppressors.
Pleiotrophin antagonizes Brd2 during neuronal differentiation.
Garcia-Dominguez et al., Sevilla, Spain. In J Cell Sci, 2014
Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell-cycle-associated genes and therefore involved in cell cycle progression.
Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer.
Chao et al., Xiamen, China. In Biomed Res Int, 2013
Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation.
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.
Müller et al., Oxford, United Kingdom. In Epigenetics Chromatin, 2013
Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containing proteins have a variety of chromatin-related functions.
Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).
Shi et al., Hefei, China. In J Biol Chem, 2011
Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).
The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.
Iwama et al., Chiba, Japan. In Blood, 2011
The Hbo1-Brd1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator genes.
Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population.
Ozaki et al., Nagoya, Japan. In Am J Med Genet B Neuropsychiatr Genet, 2010
The association of BRD1 with schizophrenia in a Japanese population, was analysed.
Support of association between BRD1 and both schizophrenia and bipolar affective disorder.
Børglum et al., Århus, Denmark. In Am J Med Genet B Neuropsychiatr Genet, 2010
BRD1 may have a role in schizophrenia and bipolar affective disorder
Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder.
Børglum et al., Århus, Denmark. In Brain Struct Funct, 2009
These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease.
Bromodomain motifs and "scaffolding"?
Denis, Boston, United States. In Front Biosci, 2001
Bromodomain-containing multiprotein complexes share some of the properties of signal transduction scaffolds.
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