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Branched chain amino-acid transaminase 2, mitochondrial

branched-chain amino acid aminotransferase, BCAT(m), BCAT-2
This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, BCAA, fibrillin-1, HAD
Papers on branched-chain amino acid aminotransferase
Ethylene and 1-MCP regulate major volatile biosynthetic pathways in apple fruit.
New
Zhang et al., Guangzhou, China. In Food Chem, Apr 2016
Allene oxide synthase (AOS), alcohol dehydrogenase 1 (ADH1), 3-ketoacyl-CoA thiolase and branched-chain amino acid aminotransferase 2 (BCAT2) decreased in ethylene-treated fruit.
Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover.
New
Kawasawa et al., Penn Hills, United States. In Physiol Genomics, Nov 2015
Mice lacking the mitochondrial branched-chain aminotransferase (BCATm/Bcat2), which interconverts leucine and α-ketoisocaproate, exhibit elevated protein turnover.
Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene.
New
Jia et al., Beijing, China. In J Inherit Metab Dis, Sep 2015
Interestingly, two heterogeneous BCAT2 gene mutations were found in the patient, including c.509G > A (p.Arg170Gln) and c.790G > A (p.Glu264Lys).
Glutamine enema regulates colonic ubiquitinated proteins but not proteasome activities during TNBS-induced colitis leading to increased mitochondrial activity.
New
Coëffier et al., Rouen, France. In Proteomics, Jul 2015
Among proteins affected by glutamine, eight proteins (GFPT1, Gapdh, Pkm2, LDH, Bcat2, ATP5a1, Vdac1, and Vdac2) were involved in metabolic pathways.
Maternal Diabetes Leads to Adaptation in Embryonic Amino Acid Metabolism during Early Pregnancy.
Navarrete Santos et al., Halle, Germany. In Plos One, 2014
The RNA amounts of three oxidizing enzymes, i.e. branched chain aminotransferase 2 (Bcat2), branched chain ketoacid dehydrogenase (Bckdha) and dehydrolipoyl dehydrogenase (Dld), were markedly increased in maternal adipose tissue and decreased in liver and skeletal muscle of diabetic rabbits than in those of controls.
Genome Sequence of Klebsiella pneumoniae YZUSK-4, a Bacterium Proposed as a Starter Culture for Fermented Meat Products.
Ge et al., Yangzhou, China. In Genome Announc, 2014
The draft genome sequence of strain YZUSK-4 may provide useful genetic information on branched-chain amino acid aminotransferase production and branched-chain amino acid metabolism.
Omental adipose tissue gene expression, gene variants, branched-chain amino acids, and their relationship with metabolic syndrome and insulin resistance in humans.
Torres et al., Mexico. In Genes Nutr, 2014
Serum BCAA concentration, the adipocyte area, and gene variants of PPARγ, ABCA1, FTO, TCF7L2, GFOD2, BCAT2, and BCKDH were determined in 115 Mexican subjects.
Reducing CO₂ to methanol using frustrated Lewis pairs: on the mechanism of phosphine-borane-mediated hydroboration of CO₂.
Fontaine et al., Québec, Canada. In J Am Chem Soc, 2014
The full mechanism of the hydroboration of CO2 by the highly active ambiphilic organocatalyst 1-Bcat-2-PPh2-C6H4 (Bcat = catecholboryl) was determined using computational and experimental methods.
Cloning and characterization of a novel fold-type I branched-chain amino acid aminotransferase from the hyperthermophilic archaeon Thermococcus sp. CKU-1.
Oikawa et al., Suita, Japan. In Extremophiles, 2014
We successfully cloned a novel branched-chain amino acid aminotransferase (Ts-BcAT; EC 2.6.1.42)
PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle.
Miura et al., Tokyo, Japan. In Plos One, 2013
In C2C12 cells, the overexpression of PGC-1α significantly increased the expression of BCAT2 and BCKDH but not BCKDK.
Effects of leucine supplementation and serum withdrawal on branched-chain amino acid pathway gene and protein expression in mouse adipocytes.
Ghosh et al., Durham, United States. In Plos One, 2013
Expression of the protein levels of branched-chain amino acid transaminase 2 (Bcat2) and branched-chain alpha keto acid dehydrogenase (Bckdha) was quantified by immunoblotting.
Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase.
GeneRIF
Conway et al., Cardiff, United Kingdom. In Acta Biochim Biophys Sin (shanghai), 2012
BCATc (cytosolic) has an overall redox potential that is 30 mV lower than BCATm (mitochondrial). Furthermore, the CXXC motif of BCATc was estimated to be 80 mV lower, suggesting that BCATm is more oxidizing in nature.
Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus.
GeneRIF
Morrison et al., Baton Rouge, United States. In J Endocrinol, 2012
knockout caused increased expression of orexigenic neuropeptides and an avoidance of branched chain amino acid but not high-protein diets
Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.
Impact
Tanaka et al., Tokyo, Japan. In Cell Metab, 2011
As well as REDD1, KLF15 inhibits mTOR activity, but via a distinct mechanism involving BCAT2 gene activation.
BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice.
GeneRIF
Vary et al., United States. In Am J Physiol Regul Integr Comp Physiol, 2010
Increased blood branched-chain amino acids is sufficient to ameliorate the catabolic effect of LPS on skeletal muscle protein synthesis; this may provide a survival advantage in response to bacterial infection.
Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.
GeneRIF
Kahn et al., Boston, United States. In J Biol Chem, 2010
BCAT2 has a role in branched chain amino acid (BCAA) metabolism modified by GLUT4 glucose-transporter
Hyperpolarized α-keto[1-(13)C]isocaproate as a (13)C magnetic resonance spectroscopic agent for profiling branched chain amino acid metabolism in tumors
Review
Shan, Bethesda, United States. In Unknown Journal, 2010
There are two isoforms, BCAT1 and BCAT2, that code for mitochondrial and cytosolic BCAT, respectively (5, 14).
Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm).
GeneRIF
Hutson et al., Blacksburg, United States. In J Biol Chem, 2010
GDH1 facilitates regeneration of BCATm that binds to E1 decarboxylase of the branched-chain alpha-keto acid dehydrogenase enzyme complex, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitrogen through glutamate.
Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism.
Review
Anders et al., New York City, United States. In Biochem Pharmacol, 2002
Nine mammalian pyridoxal 5'-phosphate (PLP)-containing enzymes catalyze cysteine S-conjugate beta-lyase reactions, including mitochondrial aspartate aminotransferase (mitAspAT), and mitochondrial branched-chain amino acid aminotransferase (BCAT(m)).
A summary of mechanistic hypotheses of gabapentin pharmacology.
Review
Singh et al., Ann Arbor, United States. In Epilepsy Res, 1998
This may occur by inhibition of glutamate synthesis by branched-chain amino acid aminotransferase (BCAA-t).
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