Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.
Amsterdam, Netherlands. In Drug Resist Updat, Mar 2015
We provide an overview on methods to overcome the BBTB, including osmotic blood-brain barrier disruption (BBBD), bradykinin receptor-mediated BBTB opening, inhibition of multidrug efflux transporters, receptor-mediated transport systems and physiological circumvention of the BBTB.
Diabetic nephropathy and proximal tubular damage.
Hong Kong, Hong Kong. In J Ren Nutr, Mar 2015
The bradykinin receptor 2 of the kallikrein-kinin system has been shown to mediate diabetic kidney injury and its blockade conferred renoprotective effects in animal models of DN.
Roles of kinins in the nervous system.
São Paulo, Brazil. In Cell Transplant, 2014
This peptide is also an important player in spinal cord injury pathophysiology and recovery, in which bradykinin receptor blockers represent substantial therapeutic potential.
Expression patterns of kinin-dependent genes in endometrial cancer.
Sosnowiec, Poland. In Int J Gynecol Cancer, 2012
The transcriptional activity of the B1 receptor for kinins increased in patients with grade 1 and grade 2 endometrial cancer when compared to the control group, whereas it decreased in patients with grade 3 endometrial cancer.