GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
Brachyury
Brachyury, Tbx1, DGS, VCFS
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
CAN, ACID, HAD, V1a, TUBE
Papers on
Brachyury
SMC1 promotes epithelial-mesenchymal transition in triple-negative breast cancer through upregulating Brachyury.
New
Shanghai, China. In Oncol Rep, Feb 2016
Brachyury is a protein that is encoded by the T gene in humans, which is a transcription factor within the T-box complex of genes.
Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations.
New
Paris, France. In Development, Feb 2016
Although TBX1 has been identified as the main gene accounting for the defects observed in human patients and mouse models, the molecular mechanisms underlying DGS etiology are poorly identified.
Rare copy number variants and congenital heart defects in the 22q11.2 deletion syndrome.
New
Philadelphia, United States. In Hum Genet, Feb 2016
UNASSIGNED: The 22q11.2 deletion syndrome (22q11DS; velocardiofacial/DiGeorge syndrome; VCFS/DGS; MIM #192430; 188400) is the most common microdeletion syndrome.
Mapping cellular processes in the mesenchyme during palatal development in the absence of Tbx1 reveals complex proliferation changes and perturbed cell packing and polarity.
New
London, United Kingdom. In J Anat, Jan 2016
Haploinsufficiency of TBX1 is believed to be a major contributor toward many of the developmental structural anomalies that occur in these syndromes, and targeted deletion of Tbx1 in the mouse reproduces many of these malformations, including cleft palate.
Factors that coordinate mesoderm specification from neuromesodermal progenitors with segmentation during vertebrate axial extension.
Review
New
Stony Brook, United States. In Semin Cell Dev Biol, Jan 2016
I will focus on evidence that the t-box transcription factor Brachyury and its downstream transcriptional targets serve as the primary factors coordinating mesoderm specification with somitogenesis.
Murine Embryonic Stem Cell Plasticity Is Regulated through Klf5 and Maintained by Metalloproteinase MMP1 and Hypoxia.
New
Bordeaux, France. In Plos One, Dec 2015
Furthermore PI3K signaling, required for the maintenance of mESC pluripotency, has no effect on mESC plasticity while displaying a major role in committed cells by stimulating expression of the mesodermal marker Brachyury at the expense of endoderm and neuroectoderm lineage markers.
Transition metal-catalyzed ketone-directed or mediated C-H functionalization.
New
Impact
Austin, United States. In Chem Soc Rev, Nov 2015
While nitrogen, phosphorus and sulfur-based functional groups (FGs) are widely employed as effective directing groups (DGs) to control the site-selectivity of C-H activation, the use of common FGs (e.g.
Substrate activation strategies in rhodium(III)-catalyzed selective functionalization of arenes.
New
Impact
Dalian, China. In Acc Chem Res, May 2015
To achieve this, directing groups (DGs) are often installed that can enhance the effective concentration of the catalyst, leading to thermodynamically stable metallacyclic intermediates.
Contemporary management of clival chordomas.
Review
New
Columbus, United States. In Curr Opin Otolaryngol Head Neck Surg, Apr 2015
Brachyury, a transcription factor in notochord development, seems to provide an excellent diagnostic marker for chordoma and may also prove to be a valuable target for chordoma therapy.
Insulin-like genes in ascidians: findings in Ciona and hypotheses on the evolutionary origins of the pancreas.
Review
New York City, United States. In Genesis, 2015
In addition, we present data suggesting that the transcription factor Ciona Brachyury is involved in the control of notochord expression of at least one of these genes, Ciona insulin-like 2. Finally, we review the information currently available on insulin-producing cells in ascidians and on pancreas-related transcription factors that might control their expression.
22q11 deletion syndrome: current perspective.
Review
İstanbul, Turkey. In Appl Clin Genet, 2014
Chromosome 22q11 is characterized by the presence of chromosome-specific low-copy repeats or segmental duplications.
NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency.
Impact
Cambridge, United Kingdom. In Cell Stem Cell, 2014
Both approaches induced BRACHYURY(+) mesoderm of distinct PS-like identities, which had differing patterning potential.
Androgen-targeted therapy-induced epithelial mesenchymal plasticity and neuroendocrine transdifferentiation in prostate cancer: an opportunity for intervention.
Review
Vancouver, Canada. In Front Oncol, 2013
Brachyury, Axl, MEK, and Aurora kinase A are molecular drivers of these programs, and inhibitors are currently in clinical trials to determine therapeutic applications.
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis.
Review
Impact
Oslo, Norway. In Endocr Rev, 2013
DGs show genomic aberrations comparable to TGCT.
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.
Impact
Copenhagen, Denmark. In Cell Metab, 2013
We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26.
Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell.
GeneRIF
Honolulu, United States. In Differentiation, 2012
We found Tcf3 as a potential target of gene repression by Nkx1-2, and the down-regulation of Tcf3 was partly required for effective activation of Brachyury by Wnt/beta-catenin signaling
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.
Impact
GeneRIF
New York City, United States. In Nature, 2012
TBX1 acts as an intrinsic rheostat of BMP signalling: it is a gatekeeper that governs the transition between stem cell quiescence and proliferation in hair follicles
Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1.
GeneRIF
Los Angeles, United States. In Plos One, 2011
Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a.
GeneRIF
Houston, United States. In Plos Genet, 2011
Tbx1, a transcription factor of the T-box family, regulates Wnt5a expression. We found that Tbx1 targets the BAF chromatin remodeling complex to the Wnt5a gene and interacts with a histone monomethyltransferase
Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells.
GeneRIF
Cambridge, United Kingdom. In Plos One, 2011
Data show that expression of Brachyury targets Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos.
