Phenoscape: Identifying Candidate Genes for Evolutionary Phenotypes.
Saskatoon, Canada. In Mol Biol Evol, Jan 2016
The experimental results were consistent with the hypotheses that these features evolved through disruption in developmental pathways at, or upstream of, brpf1 and eda/edar for the ancestral losses of basihyal element and scales, respectively.
Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.
Montréal, Canada. In J Biol Chem, Apr 2015
The multivalent chromatin regulator BRPF1 (bromodomain- and plant homeodomain-linked (PHD) zinc finger-containing protein 1) recognizes different epigenetic marks and activates three histone acetyltransferases, so it is both a reader and a co-writer of the epigenetic language.