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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tumor necrosis factor receptor superfamily, member 13C

BR-3, BAFF-R, BAFF receptor
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: erbB-2, CAN, V1a, TACI, HAD
Papers using BR-3 antibodies
BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism
Supplier
Yuan Shengtao et al., In Journal of Experimental & Clinical Cancer Research : CR, 2005
... Anti-human BAFF-R and anti-human BCMA antibodies were purchased from Abcam Inc (Cambridge, MA) ...
Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing
Supplier
Tan Ming, In PLoS ONE, 2005
... SK-BR-3 cells were maintained in RPMI (Sigma Aldrich) supplemented with 10% FBS ...
Papers on BR-3
Herceptin-conjugated temperature-sensitive immunoliposomes encapsulating gemcitabine for breast cancer.
New
Kim et al., Seoul, South Korea. In Arch Pharm Res, Feb 2016
Anticancer activity of Her-PEG-TSL-GCT was determined using HER-2 expressing breast cancer cells, SK-BR-3, in vitro and resulted in increased cytotoxicity compared to free GCT (IC20 11.7 nM) or conventional liposome lacking the targeting antibody.
B cell survival and development controlled by the coordination of NFκB family members RelB and cRel.
New
Hoffmann et al., San Diego, United States. In Blood, Feb 2016
BAFF-R is commonly thought to signal to NIK-dependent non-canonical NFκB RelB.
Asanoa endophytica sp. nov., an endophytic actinomycete isolated from the rhizome of Boesenbergia rotunda.
New
Thawai et al., Bangkok, Thailand. In Int J Syst Evol Microbiol, Feb 2016
UNASSIGNED: A novel Gram-stain-positive, non motile endophytic actinomycete, designated strain BR3-1T, which produced spore chains borne on the tip of short sporophores was isolated from the rhizome of Boesenbergia rotunda collected from Udon Thani province, Thailand.
BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses.
Review
New
Alugupalli et al., Philadelphia, United States. In Ann N Y Acad Sci, Dec 2015
B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) mediate their function in mature B cells through the BAFF receptor (BAFFR) and transmembrane activator and CAML interactor (TACI).
BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.
Review
New
Rawlings et al., Seattle, United States. In Curr Opin Immunol, Dec 2015
In this review, we highlight recent studies demonstrating the central role of the B cell antigen receptor (BCR), in coordination with other key pro-survival signals mediated by CD40, BAFF-R, TACI and/or TLRs, in regulating both negative and positive selection of autoreactive B cells.
mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes.
New
Sen et al., Suita, Japan. In Plos One, Dec 2015
Peripheral B lymphocyte survival requires the B cell receptor (BCR) and B cell activating factor (BAFF) binding to its receptor (BAFF-R).
Prognostic Significance of Promoter DNA Hypermethylation of cysteine dioxygenase 1 (CDO1) Gene in Primary Breast Cancer.
New
Watanabe et al., Sagamihara, Japan. In Plos One, Dec 2015
Promoter DNA of the CDO1 gene was hypermethylated in 6 BC cell lines except SK-BR3, and CDO1 gene expression was all silenced at mRNA level in the 7 BC cell lines.
BAFF receptors and ligands create independent homeostatic niches for B cell subsets.
Review
New
Cancro et al., Philadelphia, United States. In Curr Opin Immunol, Jun 2015
Moreover, the notion that differential BAFF receptor expression patterns establish independent homeostatic and selective niches has been strengthened.
Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets.
Review
Zamvil et al., San Francisco, United States. In Eur Neurol, 2014
Intense research efforts focusing on the immunopathological relevance of B-cells has gained significant momentum and given rise to a constellation of promising therapeutic agents for this complex B-cell-driven disease, including novel anti-CD20 antibodies, as well as agents targeting CD19 and BAFF-R.
Dendritic Cell-Derived Exosomes may be a Tool for Cancer Immunotherapy by Converting Tumor Cells into Immunogenic Targets.
Review
Barbuto et al., São Paulo, Brazil. In Front Immunol, 2013
We have, therefore, treated human breast adenocarcinoma cells (SK-BR-3) with DCs-Exo and used these to stimulate previously SK-BR-3-primed CD3(+) T-cells.
The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.
Impact
Tybulewicz et al., London, United Kingdom. In Immunity, 2013
Follicular B cell survival requires signaling from BAFFR, a receptor for BAFF and the B cell antigen receptor (BCR).
BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report.
GeneRIF
Mallat et al., Cambridge, United Kingdom. In Arterioscler Thromb Vasc Biol, 2012
BAFF-R deficiency in mice selectively alters mature B2 cell-dependent cellular and humoral immune responses and limits the development of atherosclerosis.
Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors.
GeneRIF
Eibel et al., Basel, Switzerland. In J Immunol, 2012
Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors.
BAFF-R expression correlates with positive selection of immature B cells.
GeneRIF
Rolink et al., Basel, Switzerland. In Eur J Immunol, 2012
BAFF-R expression is tightly regulated during B-cell development in mouse and human and this exprssion is correlated with posirive selection.
Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE mice attenuates atherosclerosis by potently ameliorating arterial inflammation.
GeneRIF
Toh et al., Australia. In Plos One, 2011
Targeting the BAFF-R to specifically reduce atherogenic B2 cell numbers while preserving atheroprotective B1a cell numbers may be a potential therapeutic strategy to reduce atherosclerosis by potently reducing arterial inflammation.
p52 Activation in monomorphic B-cell posttransplant lymphoproliferative disorder/diffuse large B-cell lymphoma without BAFF-R expression.
GeneRIF
Raphael et al., Villejuif, France. In Am J Pathol, 2011
The activation profile of diffuse large B-cell lymphomas/posttransplantation lymphoproliferative disorders was not associated with BAFF/BAFF-R expression, whereas nuclear p52 activation might be linked to Epstein-Barr virus.
Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.
Impact
Cancro et al., Philadelphia, United States. In Nat Immunol, 2008
The survival of transitional and mature B cells requires both the B cell antigen receptor (BCR) and BLyS receptor 3 (BR3), which suggests that these receptors send signals that are nonredundant or that engage in crosstalk with each other.
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Impact
Karin et al., San Diego, United States. In Nat Immunol, 2008
We now show that CD40 or BAFF receptor activation result in TRAF3 degradation in a cIAP1-cIAP2- and TRAF2-dependent way owing to enhanced cIAP1, cIAP2 TRAF3-directed ubiquitin ligase activity.
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.
Impact
Brink et al., Australia. In Immunity, 2008
Binding of BAFF to BAFF receptor reversed TRAF2-TRAF3-mediated suppression of B cell survival by triggering the depletion of TRAF3 protein.
Pulse Radiolysis of Potassium Bromide Solutions.
Impact
Swallow et al., In Science, 1964
After application of a 2-microsecond pulse of an electron beam to aqueous, aerated, acid solutions of KBr, transient spectra of Br2- and Br3- were observed.
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