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Ankyrin repeat and BTB

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Cul3, Ubiquitin, TdT, PTEN, Early Growth Response Protein 2
Papers on BPOZ
Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease.
Pahan et al., Chicago, United States. In Febs Lett, 2013
In the present study, we have identified a novel role of an anti-tumorigenic BTB/POZ domain containing protein-2 (BPOZ-2) in the regulation of α-synuclein accumulation in dopaminergic (DA) neurons.
Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.
Koiwai et al., Noda, Japan. In Plos One, 2011
Terminal deoxynucleotidyltransferase (TdT), which template-independently synthesizes DNA during V(D)J recombination in lymphoid cells, is ubiquitylated by a BPOZ-2/Cul3 complex, as the ubiquitin ligase, and then degraded by the 26 S proteasome.
TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm.
Koiwai et al., Noda, Japan. In Genes Cells, 2009
We isolated human cDNA clone encoding Bood POZ containing gene type 2 (BPOZ-2) as a gene with a product that binds to TdT interacting factor 1 (TdIF1) using a yeast two-hybrid system.
BPOZ-2 directly binds to eEF1A1 to promote eEF1A1 ubiquitylation and degradation and prevent translation.
Koiwai et al., Noda, Japan. In Genes Cells, 2008
BPOZ-2 promoted eEF1A1 ubiquitylation and degradation, suggesting that eEF1A1 is a substrate of BPOZ-2.
Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase.
Koiwai et al., Noda, Japan. In Genes Cells, 2008
Study showed that BPOZ-2 is a human counterpart of yeast Btb3p, which is a putative adaptor for Pcu3p-based ubiquitin ligase; BPOZ-2 bound to E3 ligase CUL3 in vitro and in vivo.
Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis.
Uziel-Fusi et al., United States. In J Cell Physiol, 2005
Seven potential genes were isolated from the OA gene library, including BPOZ, IL-17 receptor C, NADH ubiquinone oxidoreductase, COMP, Soluble carrier 16 (MCT 3), C1r, and bFGF itself.
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.
Nakamura et al., Tokyo, Japan. In Oncogene, 2001
Among them, we report here the further analyses of eight genes, EGR2/Krox-20, BPOZ, APS, HCLS1/HS1, DUSP1/MKP1, NDRG1/Drg1/RTP, NFIL3/E4BP4, and a novel gene (PINK1, PTEN-induced putative kinase).
Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain.
Liew et al., Toronto, Canada. In Biochem Biophys Res Commun, 2000
A novel human gene containing an ankyrin repeat and BTB/POZ domains (BPOZ) was isolated from a human leukocyte cDNA library.
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