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Eyes absent homolog 1

BOP, EYA1, BOR, Borealin
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, TXA2
Papers using BOP antibodies
Activation of cGMP-dependent protein kinase by protein kinase C
Kinsella B. Therese et al., In Biochimica et Biophysica Acta, 2002
... SQ29,548 and I-BOP were from the Cayman Chemical Company ...
Papers on BOP
Blast Exposure Causes Dynamic Microglial/Macrophage Responses and Microdomains of Brain Microvessel Dysfunction.
Cook et al., Boston, United States. In Neuroscience, Feb 2016
UNASSIGNED: Exposure to blast overpressure (BOP) is associated with behavioral, cognitive, and neuroimaging abnormalities.
Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders.
Pignoni et al., Washington, D.C., United States. In Comp Biochem Physiol C Toxicol Pharmacol, Dec 2015
Mutations in two genes, SIX1 and EYA1, have been identified in about half of the patients tested.
Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma.
MacLeod et al., Braunschweig, Germany. In Oncotarget, Dec 2015
In addition, cofactors EYA1 and TLE4, respectively, contrastingly mediated activation and suppression of SIX1 target gene expression.
The Proteasome Inhibitor, Bortezomib, Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors.
Giuliani et al., Parma, Italy. In J Bone Miner Res, Dec 2015
A significantly higher number of viable osteocytes was detected in patients treated with a Bortezomib (BOR)-based regimen compared to those treated without BOR.
Neomycin Damage and Regeneration of Hair Cells in Both Mechanoreceptor and Electroreceptor Lateral Line Organs of the Larval Siberian Sturgeon (Acipenser baerii).
Song et al., Shanghai, China. In J Comp Neurol, Nov 2015
To reveal the possible mechanism for ampullary hair cell regeneration, we analyzed cell proliferation and the expression of neural placodal gene eya1 during regeneration.
Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A split mouth clinical and microbiological study.
Barmappa et al., India. In J Nat Sci Biol Med, Aug 2015
The clinical parameters included plaque index (PI), bleeding on probing (BOP) measured by sulcus bleeding index (SBI), probing pocket depth (PPD), clinical attachment level (CAL) recorded at the baseline & 3(rd) month.
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
Melbye et al., Copenhagen, Denmark. In Nat Genet, 2014
Several of the identified regions harbor genes with key roles in embryonic development (including HOXA4, IRX5, IRX6 and EYA1).
EYA1-related disorders: two clinical cases and a literature review.
Martini et al., Padova, Italy. In Int J Pediatr Otorhinolaryngol, 2014
Specific findings that are helpful in the diagnosis and management of EYA1-related disorders are highlighted.
Branchio-oto-renal syndrome: comprehensive review based on nationwide surveillance in Japan.
Iijima et al., Kōbe, Japan. In Pediatr Int, 2014
Three causative genes for BOR syndrome have been reported thus far: EYA1, SIX1, and SIX5, but the causative genes for approximately half of all BOR patients remain unknown.
Anatomical Changes and Audiological Profile in Branchio-oto-renal Syndrome: A Literature Review.
Giacheti et al., Marília, Brazil. In Int Arch Otorhinolaryngol, 2014
Introduction Branchio-oto-renal (BOR) syndrome is an autosomal-dominant genetic condition with high penetrance and variable expressivity, with an estimated prevalence of 1 in 40,000.
Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.
Desai et al., San Diego, United States. In Nature, 2013
Truncated Sli15 suppresses the deletion phenotypes of the inner-centromere-targeting proteins survivin (Bir1), borealin (Nbl1), Bub1 and Sgo1 (ref.
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.
Earnshaw et al., Edinburgh, United Kingdom. In Nat Rev Mol Cell Biol, 2012
In conjunction with inner centromere protein (INCENP), borealin (also known as Dasra) and survivin it forms the chromosomal passenger complex (CPC).
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Xu et al., New York City, United States. In Development, 2012
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Why are the Interaction Energies of Charge-Transfer Complexes Challenging for DFT?
Corminboeuf et al., Lausanne, Switzerland. In J Chem Theory Comput, 2012
We establish that the interaction energies for charge-transfer complexes can only be properly described when using well-balanced functionals such as PBE0-dDsC, M06-2X, and LC-BOP-LRD.
Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome.
Hsu et al., Taipei, Taiwan. In Laryngoscope, 2012
Two novel EYA1 mutations (c.466C>T and c.1735delG) were identified in two families with BOR syndrome.
Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development.
Li et al., Boston, United States. In Dev Biol, 2012
Deletion of either or both Six1 and Eya1 genes results in genitourinary tract defects including persistent cloaca; hypospadias; and hypoplastic genitalia.
Young woman with branchio-oto-renal syndrome and a novel mutation in the EYA-1 gene.
Cerasola et al., Palermo, Italy. In Clin Nephrol, 2011
A 23 year old woman with Branchio-oto-renal syndrome presented with a novel heterozygous mutation 1420-1421delCC in exon 14 of EYA-1 gene.
Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium.
Warburton et al., Los Angeles, United States. In Development, 2011
These findings uncover novel functions for Eya1 as a crucial regulator of cell fate, cell polarity and spindle orientation in distal embryonic lung epithelium.
Chromosomal passengers: conducting cell division.
Earnshaw et al., Edinburgh, United Kingdom. In Nat Rev Mol Cell Biol, 2007
One essential 'conductor' of this symphony is the chromosomal passenger complex (CPC), which comprises Aurora-B protein kinase, the inner centromere protein INCENP, survivin and borealin (also known as Dasra-B).
A natural allele of Nxf1 suppresses retrovirus insertional mutations.
Hamilton et al., Los Angeles, United States. In Nat Genet, 2003
The modifier-of-vibrator-1 locus (Mvb1) controls levels of correctly processed mRNA from genes mutated by endogenous retrovirus insertions into introns, including the Pitpn(vb) tremor mutation and the Eya1(BOR) model of human branchiootorenal syndrome.
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