bone morphogenetic protein-2
Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration.
Seoul, South Korea. In Osteoarthritis Cartilage, Aug 2015
Upregulation of the genes interleukin 1 beta (IL-1β), p53, p16, p21, and p38 mitogen-activated protein kinase (MAPK) is responsible for the direct induction of senescence, whereas downregulation of the genes transforming growth factor-beta (TGF-β), bone morphogenetic protein-2 (BMP-2), SRY (sex determining region Y)-box 9 (SOX9), and insulin-like growth factor-1 (IGF-1), indirectly induces senescence.
Straight talk with...Harlan Krumholz.
In Nat Med, 2014
Under the agreement-the most comprehensive industry-academic partnership of its kind-YODA will independently review and make decisions about requests to access de-identified, patient-level data from the clinical studies supporting all of J&J's approved drugs.It's a major step forward for YODA, which was born in 2011 out of an initial project with the global drug and device manufacturer Medtronic, which is headquartered in Minneapolis, to release data from studies of the company's Infuse product, which contains recombinant human bone morphogenetic protein-2, used to promote bone formation.