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Gastrin-releasing peptide

Bombesin, Gastrin-Releasing Peptide, GRP
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gastrin, gastrin-releasing peptide receptor, CAN, ACID, V1a
Papers using Bombesin antibodies
The retention signal for soluble proteins of the endoplasmic reticulum.
Supplier
Abraham Edathara, In PLoS ONE, 1989
... Monoclonal anti-GRP-78 was from BD Biosciences (Franklin Lakes, NJ, USA) ...
Papers on Bombesin
Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons.
New
Shi et al., In Bmc Neurosci, 21 Nov 2014
The aim of this study was to investigate whether endoplasmic reticulum-related pathway is involved in single-prolonged stress (SPS) induced apoptosis in the mPFC of PTSD rats by examining the expression levels of ATF6 alpha (ATF6¿), two important downstream molecular chaperones of ATF6¿ in the ER stress: Glucose-regulated protein (GRP) 78 and ERP57, and apoptotic factors caspase 12, caspase 9, and caspase 3.ResultsOur results of Morris Water Maze (MWM) test showed that after SPS exposure, a striking increase of the escape latency was observed in SPS rats at day 1 through day 6, and SPS rats had much less time spent in target quadrant compared to control rats ( P < 0.01).
A combination therapy of neural and glial restricted precursor cells and chronic quipazine treatment paired with passive cycling promotes quipazine-induced stepping in adult spinalized rats.
New
Shumsky et al., In J Spinal Cord Med, 20 Nov 2014
UNLABELLED: Introduction In order to develop optimal treatments to promote recovery from complete spinal cord injury (SCI), we examined the combination of: (1) a cellular graft of neural and glial restricted precursor (NRP/GRP) cells, (2) passive exercise, and (3) chronic quipazine treatment on behavioral outcomes and compared them with the individual treatment elements.
Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression.
New
Ko et al., In Bmc Complement Altern Med, 15 Nov 2014
BACKGROUND: Glucose-regulated proteins (GRP) are induced in the cancer microenvironment to promote tumor survival, metastasis and drug resistance.
Targeting Neuropeptide Receptors for Cancer Imaging and Therapy: Perspectives with Bombesin, Neurotensin, and Neuropeptide-Y Receptors.
Review
New
Hindié et al., New Delhi, India. In J Nucl Med, 04 Oct 2014
This review focuses on 3 neuropeptide receptor systems (bombesin, neurotensin, and neuropeptide-Y) that offer high potential in the field of nuclear oncology.
Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues.
Review
New
Baldwin et al., Melbourne, Australia. In Bju Int, Mar 2014
Gastrin-releasing peptide (GRP) acts as an important regulatory peptide in several normal physiological processes and as a growth factor in certain cancers.
Diversification of the plant-specific hybrid glycine-rich protein (HyGRP) genes in cereals.
New
Sato et al., Sapporo, Japan. In Front Plant Sci, Dec 2013
Plant-specific hybrid proline- or glycine-rich proteins (HyP/GRPs) are involved in diverse gene functions including plant development and responses to biotic and abiotic stresses.
Insect prophenoloxidase: the view beyond immunity.
Review
New
Ling et al., Shanghai, China. In Front Physiol, Dec 2013
The insect PPO activation pathway incorporates several important proteins, including pattern-recognition receptors (PGRP, β GRP, and C-type lectins), serine proteases, and serine protease inhibitors (serpins).
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs.
Review
New
Tesauro et al., Napoli, Italy. In Int J Nanomedicine, Dec 2013
The most studied targeting membrane receptors are considered: somatostatin receptors; cholecystokinin receptors; receptors associated with the Bombesin like peptides family; luteinizing hormone-releasing hormone receptors; and neurotensin receptors.
Corrigendum: Oxygen, Gastrin-Releasing Peptide, and Pediatric Lung Disease: Life in the Balance.
New
Sunday, Durham, United States. In Front Pediatr, Dec 2013
UNLABELLED: [This corrects the article on p. 72 in vol.
An update on peripheral mechanisms and treatments of itch.
Review
Takamori et al., Japan. In Biol Pharm Bull, 2012
Moreover, itch-mediating fibers such as gastrin-releasing peptide(+) (GRP(+)) and Mas-related G-protein coupled receptor A3(+) (MrgprA3(+)) fibers are present in the skin.
Characteristics and clinical validity of two immunoassays for ProGRP.
GeneRIF
Paus et al., Oslo, Norway. In Tumour Biol, 2012
Data indicate that progastrin-releasing peptide (proGRP) assays with both time-resolved immunofluorometric assay (TR-IFMA) and Advanced Life Science Institute (ALSI) ELISA showed good clinical validity.
The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.
GeneRIF
Mulder et al., Penn Hills, United States. In J Biol Chem, 2012
km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways
Correlations between serial pro-gastrin-releasing peptide and neuron-specific enolase levels, and the radiological response to treatment and survival of patients with small-cell lung cancer.
GeneRIF
Yamamoto et al., Shizuoka, Japan. In Lung Cancer, 2012
Percent changes in serum ProGRP showed better correlation to the sum of the tumor diameters (SOD) and prognostic impact than that of NSE.
Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility.
GeneRIF
Smith et al., Cambridge, United Kingdom. In J Physiol, 2012
Tonic stretch of human myometrium increases contractility and stimulates the expression of a known smooth muscle stimulatory agonist, GRP. GRP receptor antagonists attenuate the effect of stretch.
Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
GeneRIF
Sullivan et al., Santa Cruz, United States. In Mol Biol Cell, 2012
Relationships between DNA replication, chromosome condensation, and anaphase entry are mediated by the cell cycle kinases Grp (Chk1) and dWee1 (Wee1).
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.
Impact
Chen et al., Saint Louis, United States. In Cell, 2011
MOR1D heterodimerizes with gastrin-releasing peptide receptor (GRPR) in the spinal cord, relaying itch information.
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors.
Impact
Rudin et al., Boston, United States. In J Clin Oncol, 2011
Pro-gastrin releasing peptide (pro-GRP) was identified as a surrogate marker of Bcl-2 amplification and changes correlated with changes in tumor volume.
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Impact
Reitman et al., Rahway, United States. In Cell Metab, 2010
Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown.
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos.
Impact
Kintner et al., San Diego, United States. In Nat Genet, 2008
We show that the cilia that underlie left-right patterning on the Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle are severely shortened or fail to form in Foxj1 morphants.
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Review
Impact
Benya et al., Bethesda, United States. In Pharmacol Rev, 2008
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB(1)), the gastrin-releasing peptide (GRP) receptor (BB(2)), and the orphan receptor bombesin receptor subtype 3 (BRS-3) (BB(3)).
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