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Gastrin-releasing peptide

Bombesin, Gastrin-Releasing Peptide, GRP
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gastrin, gastrin-releasing peptide receptor, CAN, ACID, V1a
Papers using Bombesin antibodies
The retention signal for soluble proteins of the endoplasmic reticulum.
Supplier
Abraham Edathara, In PLoS ONE, 1989
... Monoclonal anti-GRP-78 was from BD Biosciences (Franklin Lakes, NJ, USA) ...
Papers on Bombesin
Dosimetry and First Clinical Evaluation of the New 18F-Radiolabeled Bombesin Analogue BAY 864367 in Patients with Prostate Cancer.
New
Schaefer et al., Zürich, Switzerland. In J Nucl Med, 31 Mar 2015
UNLABELLED: The aim of this first-in-man study was to demonstrate the feasibility, safety, and tolerability, as well as provide dosimetric data and evaluate the imaging properties, of the bombesin analogue BAY 864367 for PET/CT in a small group of patients with primary and recurrent prostate cancer (PCa).
Cross-talk between endothelial and tumor cells via basic fibroblast growth factor and vascular endothelial growth factor signaling promotes lung cancer growth and angiogenesis.
New
Che et al., Chengdu, China. In Oncol Lett, 31 Mar 2015
CD105 was used as a marker of activated blood vessel ECs in the tumor microenvironment and glucose-regulated protein-78 (GRP-78) was used as a biomarker of the A549 cells.
Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats.
New
Liu et al., Kunshan, China. In Ren Fail, 24 Mar 2015
The ER stress was assessed with glucose-regulated protein (GRP) 78 expression, and the proapoptotic response was detected with CCAAT/enhancer-binding protein homologous protein (CHOP) and caspase-12 expressions by Western Blot.
Bombesin staining in neuroendocrine cell hyperplasia of infancy (NEHI) and other childhood interstitial lung diseases (chILD).
New
Nicholson et al., London, United Kingdom. In Histopathology, 13 Mar 2015
AIM: We have analyzed levels of bombesin-positive neuroendocrine cells (NECs) in neuroendocrine cell hyperplasia of infancy (NEHI) and other childhood interstitial lung diseases (chILDs) in order to validate proposed histological criteria for NEHI and investigate its etiology.
The effect of macrocyclic chelators on the targeting properties of the (68)Ga-labeled gastrin releasing peptide receptor antagonist PEG2-RM26.
New
Orlova et al., Uppsala, Sweden. In Nucl Med Biol, Jan 2015
Bombesin (BN) analogs are short peptides with a high affinity for GRPR.
Gastrin-releasing peptide receptor signaling in the integration of stress and memory.
Review
New
Merali et al., Porto Alegre, Brazil. In Neurobiol Learn Mem, Jul 2014
Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin.
[Spinal gastrin-releasing peptide system mediates sexual function of males: advances in studies].
Review
New
Liu et al., In Zhonghua Nan Ke Xue, Jun 2014
A collection of neurons in the upper lumbar spinal cord (lumbar segments 3 and 4) of male rats project to the lower lumbar spinal cord (lumbar segments 5 and 6) and release a gastrin-releasing peptide (GRP) to the somatic and autonomic regions, which are known to regulate male sexual reflexes.
Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues.
Review
New
Baldwin et al., Melbourne, Australia. In Bju Int, Mar 2014
Gastrin-releasing peptide (GRP) acts as an important regulatory peptide in several normal physiological processes and as a growth factor in certain cancers.
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs.
Review
Tesauro et al., Napoli, Italy. In Int J Nanomedicine, 2013
The most studied targeting membrane receptors are considered: somatostatin receptors; cholecystokinin receptors; receptors associated with the Bombesin like peptides family; luteinizing hormone-releasing hormone receptors; and neurotensin receptors.
Insect prophenoloxidase: the view beyond immunity.
Review
Ling et al., Shanghai, China. In Front Physiol, 2013
The insect PPO activation pathway incorporates several important proteins, including pattern-recognition receptors (PGRP, β GRP, and C-type lectins), serine proteases, and serine protease inhibitors (serpins).
Characteristics and clinical validity of two immunoassays for ProGRP.
GeneRIF
Paus et al., Oslo, Norway. In Tumour Biol, 2012
Data indicate that progastrin-releasing peptide (proGRP) assays with both time-resolved immunofluorometric assay (TR-IFMA) and Advanced Life Science Institute (ALSI) ELISA showed good clinical validity.
The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.
GeneRIF
Mulder et al., Penn Hills, United States. In J Biol Chem, 2012
km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways
Correlations between serial pro-gastrin-releasing peptide and neuron-specific enolase levels, and the radiological response to treatment and survival of patients with small-cell lung cancer.
GeneRIF
Yamamoto et al., Shizuoka, Japan. In Lung Cancer, 2012
Percent changes in serum ProGRP showed better correlation to the sum of the tumor diameters (SOD) and prognostic impact than that of NSE.
Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility.
GeneRIF
Smith et al., Cambridge, United Kingdom. In J Physiol, 2012
Tonic stretch of human myometrium increases contractility and stimulates the expression of a known smooth muscle stimulatory agonist, GRP. GRP receptor antagonists attenuate the effect of stretch.
Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
GeneRIF
Sullivan et al., Santa Cruz, United States. In Mol Biol Cell, 2012
Relationships between DNA replication, chromosome condensation, and anaphase entry are mediated by the cell cycle kinases Grp (Chk1) and dWee1 (Wee1).
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.
Impact
Chen et al., Saint Louis, United States. In Cell, 2011
MOR1D heterodimerizes with gastrin-releasing peptide receptor (GRPR) in the spinal cord, relaying itch information.
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors.
Impact
Rudin et al., Boston, United States. In J Clin Oncol, 2011
Pro-gastrin releasing peptide (pro-GRP) was identified as a surrogate marker of Bcl-2 amplification and changes correlated with changes in tumor volume.
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Impact
Reitman et al., Rahway, United States. In Cell Metab, 2010
Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown.
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos.
Impact
Kintner et al., San Diego, United States. In Nat Genet, 2008
We show that the cilia that underlie left-right patterning on the Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle are severely shortened or fail to form in Foxj1 morphants.
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Review
Impact
Benya et al., Bethesda, United States. In Pharmacol Rev, 2008
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB(1)), the gastrin-releasing peptide (GRP) receptor (BB(2)), and the orphan receptor bombesin receptor subtype 3 (BRS-3) (BB(3)).
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