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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Gastrin-releasing peptide

Bombesin, Gastrin-Releasing Peptide, GRP
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gastrin, gastrin-releasing peptide receptor, CAN, ACID, V1a
Papers using Bombesin antibodies
The retention signal for soluble proteins of the endoplasmic reticulum.
Supplier
Abraham Edathara, In PLoS ONE, 1989
... Monoclonal anti-GRP-78 was from BD Biosciences (Franklin Lakes, NJ, USA) ...
Papers on Bombesin
A new (68)Ga-labeled BBN peptide with a hydrophilic linker for GRPR-targeted tumor imaging.
New
Yan et al., Wuxi, China. In Amino Acids, Jun 2014
Bombesin (BBN) is a peptide exhibiting high affinity for the gastrin-releasing peptide receptor (GRPR), which is overexpressed on several types of cancers.
Peptide conjugated polymeric nanoparticles as a carrier for targeted delivery of docetaxel.
New
Sistla et al., Hyderābād, India. In Colloids Surf B Biointerfaces, Jun 2014
The above studies showed that Bombesin conjugated nanocarrier system could be a promising carrier for active targeting of anticancer drugs in GRP receptor over expressing cancer cells.
ATF4 (activating transcription factor 4) from grass carp (Ctenopharyngodon idella) modulates the transcription initiation of GRP78 and GRP94 in CIK cells.
New
Hu et al., Nanchang, China. In Fish Shellfish Immunol, May 2014
GRP78 and GRP94, belong to GRP (glucose-regulated protein) family of endoplasmatic reticulum (ER) chaperone superfamily, are essential for cell survival under ER stress.
Synthesis and in vitro and in vivo evaluation of SiFA-tagged bombesin and RGD peptides as tumor imaging probes for positron emission tomography.
New
Wängler et al., München, Germany. In Bioconjug Chem, May 2014
Gastrin-releasing-peptide (GRP)-receptors and αvβ3-integrins are widely discussed as potential target structures for oncological imaging with positron emission tomography (PET).
Targeting GRPR in urological cancers--from basic research to clinical application.
Review
New
Reubi et al., Freiburg, Germany. In Nat Rev Urol, Apr 2013
Gastrin releasing peptide (GRP) is a regulatory peptide that acts through its receptor (GRPR) to regulate physiological functions in various organs.
Influence of GRPR and BDNF/TrkB signaling on the viability of breast and gynecologic cancer cells.
Roesler et al., Philippines. In Mol Clin Oncol, 2013
Scientific findings indicate that compounds blocking gastrin-releasing peptide receptors (GRPR) or tropomyosin receptor kinase (Trk) receptors are likely to have antiproliferative activities against cancer cells.
Mortalin - a multipotent chaperone regulating cellular processes ranging from viral infection to neurodegeneration.
Review
Kovacech et al., Bratislava, Slovakia. In Acta Virol, 2012
This protein has been attributed many cellular functions, including energy generation, stress response, carcinogenesis and involvement in neurodegenerative diseases, which is well documented by many names it has been given (CSA, MOT, MOT2, GRP75, PBP74, GRP-75, HSPA9B, MGC4500, MTHSP75, and mortalin).
An update of radiolabeled bombesin analogs for gastrin-releasing peptide receptor targeting.
Review
Elsinga et al., Groningen, Netherlands. In Curr Pharm Des, 2012
Lack of suitable radiotracers is the major issue for nuclear imaging of prostate cancer, although radiolabeled bombesin (BN) peptides targeting the Gastrin-Releasing Peptide Receptor (GRPR) on tumor cells are widely investigated.
The role of bombesin and bombesin-related peptides in the short-term control of food intake.
Review
Sayegh, United States. In Prog Mol Biol Transl Sci, 2012
The mammalian homologs of this peptide include three forms of gastrin-releasing peptide (GRP): GRP-10, GRP-27, and GRP-29, and a 10-amino acid peptide referred to as neuromedin-B (NMB).
An update on peripheral mechanisms and treatments of itch.
Review
Takamori et al., Japan. In Biol Pharm Bull, 2012
Moreover, itch-mediating fibers such as gastrin-releasing peptide(+) (GRP(+)) and Mas-related G-protein coupled receptor A3(+) (MrgprA3(+)) fibers are present in the skin.
Characteristics and clinical validity of two immunoassays for ProGRP.
GeneRIF
Paus et al., Oslo, Norway. In Tumour Biol, 2012
Data indicate that progastrin-releasing peptide (proGRP) assays with both time-resolved immunofluorometric assay (TR-IFMA) and Advanced Life Science Institute (ALSI) ELISA showed good clinical validity.
The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.
GeneRIF
Mulder et al., Penn Hills, United States. In J Biol Chem, 2012
km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways
Correlations between serial pro-gastrin-releasing peptide and neuron-specific enolase levels, and the radiological response to treatment and survival of patients with small-cell lung cancer.
GeneRIF
Yamamoto et al., Shizuoka, Japan. In Lung Cancer, 2012
Percent changes in serum ProGRP showed better correlation to the sum of the tumor diameters (SOD) and prognostic impact than that of NSE.
Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility.
GeneRIF
Smith et al., Cambridge, United Kingdom. In J Physiol, 2012
Tonic stretch of human myometrium increases contractility and stimulates the expression of a known smooth muscle stimulatory agonist, GRP. GRP receptor antagonists attenuate the effect of stretch.
Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
GeneRIF
Sullivan et al., Santa Cruz, United States. In Mol Biol Cell, 2012
Relationships between DNA replication, chromosome condensation, and anaphase entry are mediated by the cell cycle kinases Grp (Chk1) and dWee1 (Wee1).
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.
Impact
Chen et al., Saint Louis, United States. In Cell, 2011
MOR1D heterodimerizes with gastrin-releasing peptide receptor (GRPR) in the spinal cord, relaying itch information.
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors.
Impact
Rudin et al., Boston, United States. In J Clin Oncol, 2011
Pro-gastrin releasing peptide (pro-GRP) was identified as a surrogate marker of Bcl-2 amplification and changes correlated with changes in tumor volume.
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Impact
Reitman et al., Rahway, United States. In Cell Metab, 2010
Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown.
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos.
Impact
Kintner et al., San Diego, United States. In Nat Genet, 2008
We show that the cilia that underlie left-right patterning on the Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle are severely shortened or fail to form in Foxj1 morphants.
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Review
Impact
Benya et al., Bethesda, United States. In Pharmacol Rev, 2008
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB(1)), the gastrin-releasing peptide (GRP) receptor (BB(2)), and the orphan receptor bombesin receptor subtype 3 (BRS-3) (BB(3)).
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