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Gastrin-releasing peptide

Bombesin, Gastrin-Releasing Peptide, GRP
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gastrin, gastrin-releasing peptide receptor, CAN, ACID, V1a
Papers using Bombesin antibodies
The retention signal for soluble proteins of the endoplasmic reticulum.
Supplier
Abraham Edathara, In PLoS ONE, 1989
... Monoclonal anti-GRP-78 was from BD Biosciences (Franklin Lakes, NJ, USA) ...
Papers on Bombesin
Imaging heterogeneity of peptide delivery and binding in solid tumors using SPECT imaging and MRI.
New
Veenland et al., Rotterdam, Netherlands. In Ejnmmi Res, 31 Dec 2016
METHODS: High-resolution SPECT and dynamic contrast-enhanced (DCE)-MRI were acquired in six mice bearing PC295 PDX tumors expressing the gastrin-releasing peptide (GRP) receptor.
Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells.
New
Roesler et al., Porto Alegre, Brazil. In Mol Neurobiol, Feb 2016
The activation of gastrin-releasing peptide receptors (GRPR) stimulates GBM cell proliferation, whereas GRPR antagonists induce antiproliferative effects in in vitro and in vivo experimental models of GBM.
Influence of abiraterone acetate on circulating neuromediators in chemotherapy-naïve castration-resistant prostate cancer.
New
Heinrich et al., Mannheim, Germany. In Prostate, Feb 2016
We evaluated how treatment with AA influences circulating neuromediators chromogranin A (CGA), neuron-specific enolase (NSE), and pro-gastrin-releasing peptide (Pro-GRP) in chemotherapy-naïve CRPC patients.
GRP-3 and KAPP, encoding interactors of WAK1, negatively affect defense responses induced by oligogalacturonides and local response to wounding.
New
De Lorenzo et al., Roma, Italy. In J Exp Bot, Feb 2016
The Arabidopsis Wall-Associated Kinase 1 (WAK1), a receptor of OGs, has been described to form a complex with a cytoplasmic plasma membrane-localized kinase-associated protein phosphatase (KAPP) and a glycine-rich protein (GRP-3) that we find localized mainly in the cell wall and, in a small part, on the plasma membrane.
ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells.
New
Zhang et al., Chengdu, China. In Chem Biol Interact, Feb 2016
Then, we demonstrated that ER stress was contributed to this synergistic effect, which was manifested by increased the expression levels of ER stress hallmarks, including 78-kDa glucose-regulated protein (GRP 78), caspase 12 and C/EBP-homologous protein (CHOP), In addition, mitochondrial dysfunction was observed after exposure of A549 cells to resveratrol or/and ATO, which was displayed by some alterations of mitochondria-related events, such as loss of mitochondrial membrane potential, cytochrome c release and changes of Bax and Bcl-2 expressions.
New radiopharmaceutical agents for the treatment of castration-resistant prostate cancer.
Review
New
Chinol et al., Milano, Italy. In Q J Nucl Med Mol Imaging, Dec 2015
Gastrin-releasing peptide receptors (GRPr) are also highly overexpressed in PCa.
STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.
New
Impact
Tsuda et al., Fukuoka, Japan. In Nat Med, Aug 2015
Mice with atopic dermatitis exhibited an increase in scratching elicited by intrathecal administration of the itch-inducer gastrin-releasing peptide (GRP), and this enhancement was normalized by suppressing STAT3-mediated reactive astrogliosis.
Bombesin-like peptides and their receptors: recent findings in pharmacology and physiology.
Review
New
Qin et al., Changsha, China. In Curr Opin Endocrinol Diabetes Obes, Feb 2015
PURPOSE OF REVIEW: To highlight the research progress of roles of bombesin-like peptides and their receptors in pharmacology and physiology.
Gastrointestinal peptides and itch sensation.
Review
New
Weber, Boston, United States. In Curr Opin Endocrinol Diabetes Obes, Feb 2015
PURPOSE OF REVIEW: To highlight the most recent advances regarding gastrointestinal peptides and their relation to chronic itch, with focus on gastrin-releasing peptide (GRP), substance P, and their respective receptors.
Bombesin receptor subtype 3 as a potential target for obesity and diabetes.
Review
Jensen et al., Madrid, Spain. In Expert Opin Ther Targets, 2014
It involves recognition of the central role the G-protein-coupled receptor, bombesin receptor subtype 3 (BRS-3) plays in energy/glucose metabolism.
Transmission of pruriceptive signals.
Review
Hoon et al., Bethesda, United States. In Handb Exp Pharmacol, 2014
Current data reveal that DRG neurons and spinal cord cells use a remarkably selective set of transmitters to convey pruritic information from the periphery to the brain: glutamate and Nppb are released from primary itch-sensory cells; these molecules activate secondary spinal cord pruriceptive-specific neurons, which in turn utilize Grp to activate tertiary pruriceptive-selective neurons.
Characteristics and clinical validity of two immunoassays for ProGRP.
GeneRIF
Paus et al., Oslo, Norway. In Tumour Biol, 2012
Data indicate that progastrin-releasing peptide (proGRP) assays with both time-resolved immunofluorometric assay (TR-IFMA) and Advanced Life Science Institute (ALSI) ELISA showed good clinical validity.
The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.
GeneRIF
Mulder et al., Penn Hills, United States. In J Biol Chem, 2012
km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways
Correlations between serial pro-gastrin-releasing peptide and neuron-specific enolase levels, and the radiological response to treatment and survival of patients with small-cell lung cancer.
GeneRIF
Yamamoto et al., Shizuoka, Japan. In Lung Cancer, 2012
Percent changes in serum ProGRP showed better correlation to the sum of the tumor diameters (SOD) and prognostic impact than that of NSE.
Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility.
GeneRIF
Smith et al., Cambridge, United Kingdom. In J Physiol, 2012
Tonic stretch of human myometrium increases contractility and stimulates the expression of a known smooth muscle stimulatory agonist, GRP. GRP receptor antagonists attenuate the effect of stretch.
Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.
GeneRIF
Sullivan et al., Santa Cruz, United States. In Mol Biol Cell, 2012
Relationships between DNA replication, chromosome condensation, and anaphase entry are mediated by the cell cycle kinases Grp (Chk1) and dWee1 (Wee1).
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.
Impact
Chen et al., Saint Louis, United States. In Cell, 2011
MOR1D heterodimerizes with gastrin-releasing peptide receptor (GRPR) in the spinal cord, relaying itch information.
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors.
Impact
Rudin et al., Boston, United States. In J Clin Oncol, 2011
Pro-gastrin releasing peptide (pro-GRP) was identified as a surrogate marker of Bcl-2 amplification and changes correlated with changes in tumor volume.
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Impact
Reitman et al., Rahway, United States. In Cell Metab, 2010
Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown.
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos.
Impact
Kintner et al., San Diego, United States. In Nat Genet, 2008
We show that the cilia that underlie left-right patterning on the Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle are severely shortened or fail to form in Foxj1 morphants.
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