Gastrointestinal peptides and itch sensation.
Boston, United States. In Curr Opin Endocrinol Diabetes Obes, Feb 2015
PURPOSE OF REVIEW: To highlight the most recent advances regarding gastrointestinal peptides and their relation to chronic itch, with focus on gastrin-releasing peptide (GRP), substance P, and their respective receptors.
Transmission of pruriceptive signals.
Bethesda, United States. In Handb Exp Pharmacol, Dec 2014
Current data reveal that DRG neurons and spinal cord cells use a remarkably selective set of transmitters to convey pruritic information from the periphery to the brain: glutamate and Nppb are released from primary itch-sensory cells; these molecules activate secondary spinal cord pruriceptive-specific neurons, which in turn utilize Grp to activate tertiary pruriceptive-selective neurons.
Insect prophenoloxidase: the view beyond immunity.
Shanghai, China. In Front Physiol, 2013
The insect PPO activation pathway incorporates several important proteins, including pattern-recognition receptors (PGRP, β GRP, and C-type lectins), serine proteases, and serine protease inhibitors (serpins).