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BCL2-related ovarian killer

Bok, Bcl-2-related ovarian killer, Bcl-2-related ovarian killer protein
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: bcl-2, Bax, Bcl-xL, PrP, Bak
Papers on Bok
Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats.
New
Rao et al., Bengaluru, India. In Syst Biol Reprod Med, Dec 2015
Interestingly, the differentially expressed proteins such as FIGNL1 (DNA repair) and BOK (apoptotic protein) have not been previously reported in the rat primordial follicles and these proteins can be related to some common features of ovarian aging such as loss of follicle reserve and genome integrity.
cIAP1 attenuates shear stress-induced hBMSC apoptosis for tissue-engineered blood vessels through the inhibition of the mitochondrial apoptosis pathway.
New
Yi et al., Xi'an, China. In Life Sci, Oct 2015
Microarray screening and RT-PCR revealed that Bcl-2-related ovarian killer (BOK) and apoptotic protease-activating factor 1 (APAF1), key molecules of the mitochondrial apoptosis pathway, were markedly upregulated under 3-dyn/cm(2) shear stress.
Molecular profiles and pathogen-induced transcriptional responses of prawn B cell lymphoma-2 related ovarian killer protein (BOK).
New
Arockiaraj et al., Chennai, India. In Fish Shellfish Immunol, Aug 2015
In this study, we have reported a molecular characterization of the first B cell lymphoma-2 (BCL-2) related ovarian killer protein (BOK) from freshwater prawn Macrobrachium rosenbergii (Mr).
BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress.
New
Katz et al., New Haven, United States. In Proc Natl Acad Sci U S A, Jul 2015
B-cell lymphoma 2 (BCL-2) ovarian killer (BOK) is a BCL-2 family protein with high homology to the multidomain proapoptotic proteins BAX and BAK, yet Bok(-/-) and even Bax(-/-)Bok(-/-) and Bak(-/-)Bok(-/-) mice were reported to have no overt phenotype or apoptotic defects in response to a host of classical stress stimuli.
Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia.
New
Caniggia et al., Toronto, Canada. In Autophagy, May 2015
ASAH1 inhibition or ceramide treatment induced autophagy in human trophoblast cells via a shift of the BOK-MCL1 rheostat toward prodeath BOK.
Pifithrin-α ameliorates resveratrol-induced two-cell block in mouse preimplantation embryos in vitro.
New
Kim et al., Seoul, South Korea. In Theriogenology, Apr 2015
Resveratrol was found to significantly increase the expressions of p53, p21, Atf3, smac/Diablo, Bax, Bak1, Bok, and Noxa mRNA in the embryos, whereas Cullin 3 and Cdk1 expressions were decreased.
A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence.
Arnold et al., Freiburg, Germany. In Stem Cells Int, 2014
Analyses by qRT-PCR and in situ hybridisation validated novel TSC- and chorion-specific marker genes, such as Bok/Mtd, Cldn26, Duox2, Duoxa2, Nr0b1, and Sox21.
Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells.
Lu et al., Beijing, China. In Oncotarget, 2014
Action mechanism studies indicated that the enhanced efficacy of the multifunctional targeting drugs-loaded liposomes could be due to the following aspects: evading the rapid elimination from blood circulation; crossing the BBB effectively; improving drug uptake by glioma cells and GSCs; down-regulating the overexpressed ABC transporters; inducing apoptosis of GSCs via up-regulating apoptotic receptor/ligand (Fas/Fasl), activating apoptotic enzymes (caspases 8, 9 and 3), activating pro-apoptotic proteins (Bax and Bok), activating tumor suppressor protein (P53) and suppressing anti-apoptotic proteins (Bcl-2 and Mcl-1).
ABCG1 rs57137919G>a polymorphism is functionally associated with varying gene expression and apoptosis of macrophages.
Yan et al., Beijing, China. In Plos One, 2013
Proapoptotic genes Bok and Bid mRNA levels were significantly increased in macrophages from the A/A genotype compared with those from the G/G genotype.
BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.
GeneRIF
Kaufmann et al., Melbourne, Australia. In Cell Death Differ, 2012
Bok protein have a role that largely overlaps with that of other members of the Bcl-2 family, or may have a function restricted to specific stress stimuli and/or tissues.
Nuclear export of proteins and drug resistance in cancer.
Review
Sullivan et al., Tampa, United States. In Biochem Pharmacol, 2012
Proteins that are exported in cancer include tumor-suppressive proteins such as retinoblastoma, APC, p53, BRAC1, FOXO proteins, INI1/hSNF5, galectin-3, Bok, nucleophosmin, RASSF2, Merlin, p21(CIP), p27(KIP1), N-WASP/FAK, estradiol receptor and Tob, drug targets topoisomerase I and IIα and BCR-ABL, and the molecular chaperone protein Hsp90.
Myocardin-related transcription factor A regulates expression of Bok and Noxa and is involved in apoptotic signalling.
GeneRIF
Posern et al., Martinsried, Germany. In Cell Cycle, 2012
two proapoptotic Bcl-2 family members Bok and Noxa/Pmaip are directly transcriptionally induced by activated MAL and upon activation of the actin-MAL-SRF pathway
Biological activity of piceatannol: leaving the shadow of resveratrol.
Review
Murias et al., Poznań, Poland. In Mutat Res, 2012
Bik, Bok, Fas: P21(WAF1) down-regulation of Bcl-xL; BCL-2, clAP, activation of caspases (-3, -7,- 8, -9), loss of mitochondrial potential, and release of cytochrome c.
Regulation of cell death in human fetal and adult ovaries--role of Bok and Bcl-X(L).
GeneRIF
Tapanainen et al., Oulu, Finland. In Mol Cell Endocrinol, 2011
The results suggest important roles for Bok and Bcl-X(L) in human ovarian development, follicle maturation and apoptosis.
Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia.
GeneRIF
Caniggia et al., Canada. In Cell Death Differ, 2010
Data conclude that Mtd-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd found in PE may contribute to increased trophoblast proliferation.
A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok.
GeneRIF
De Geyter et al., Basel, Switzerland. In Int J Oncol, 2009
BOKAS is a natural antisense transcript that regulates the pro-apoptotic activity of human Bok
Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy.
Review
Los et al., Winnipeg, Canada. In Drug Resist Updat, 2007
Bcl2, Bcl-X(L) Mcl-1(L); Bax, Bok/Mtd, Bak, and Bcl-X(S); Bad, Bid, Bim(EL), Bmf, Mcl-1(S)) are highlighted both for their apoptosis-regulating capacity and also for their effect on the cell cycle progression.
Tissue-specific Bcl-2 protein partners in apoptosis: An ovarian paradigm.
Review
Impact
Hsueh et al., Stanford, United States. In Physiol Rev, 2000
We identified Mcl-1 as the main ovarian antiapoptotic Bcl-2 protein, the novel Bok (Bcl-2-related ovarian killer) as the proapoptotic protein, as well as BOD (Bcl-2-related ovarian death agonist) and BAD as the proapoptotic ligands.
Intracellular mechanisms of ovarian cell apoptosis.
Review
Hsueh et al., Stanford, United States. In Mol Cell Endocrinol, 1998
The use of 2-hybrid analysis resulted in the isolation of a novel pro-apoptotic Bcl-2 protein, Bcl-2-related ovarian killer (Bok) and the identification of upstream mediators for ovarian cell apoptosis.
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