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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Boc homolog

Boc
The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, PrP, telomerase reverse transcriptase
Papers using Boc antibodies
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Supplier
Navarro Alfons, In PLoS ONE, 2006
... The pan-caspase inhibitor Boc-d-fmk was purchased from Biovision (Mountain View, CA, USA) ...
Drug discovery in the ubiquitin-proteasome system.
Supplier
Wang Ping, In PLoS ONE, 2005
... # EW9805), t-butoxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin (Boc-LRR-AMC), and acetyl-L-norleucyl-L-prolyl-L-norleucyl-L-aspartyl-methylcoumarylamide (Ac-nLPnLD-AMC) were obtained from Biomol International ...
Partial D-amino acid substitution: Improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptide
Supplier
Rash Lachlan D. et al., In Marine Drugs, 2004
... -Boc-L-amino acids were from Merck Pty Ltd ...
Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory pain.
Supplier
Bishai William, In PLoS Pathogens, 2002
... Rabbit anti-Met-enkephalin or anti-rat-β-endorphin Abs as well as purified Met-enkephalin and Boc-FLFLF were purchased from Bachem, Weil am Rhein, Germany ...
Virus-expressed, recombinant single-chain antibody blocks sporozoite infection of salivary glands in Plasmodium gallinaceum-infected Aedes aegypti.
Supplier
Ratner Adam J., In PLoS ONE, 1999
... The following side-chain protected Boc-amino acids were employed from Bachem Inc ...
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Papers on Boc
Novel renin inhibitors containing derivatives of N-alkylleucyl-β-hydroxy-γ-amino acids.
New
Sokulski et al., Warsaw, Poland. In J Pept Sci, Feb 2016
The inhibitor Boc-Phe(4-OMe)-MeLeu-AHGHA-OEt was obtained in the form of an ethyl ester.
The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells.
New
Hoskin et al., Halifax, Canada. In J Cell Biochem, Feb 2016
Induction of caspase-dependent apoptosis by fisetin was confirmed by reduced killing of TNBC cells in the presence of the pan-caspase inhibitors Z-VAD-FMK and BOC-D-FMK.
Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.
New
Bertrand et al., Genève, Switzerland. In Bioorg Med Chem Lett, Feb 2016
Intermediate and target compounds obtained were tested for their ability to induce HDAC inhibition and tubulin acetylation, revealing the key role of the tert-butyloxycarbonyl (BOC) group for more HDAC6 selectivity.
Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics.
New
Mosberg et al., Ann Arbor, United States. In Acs Med Chem Lett, Jan 2016
We report here a short, three-step synthesis of Boc-2',6'-dimethyl-l-tyrosine (3a) utilizing a microwave-assisted Negishi coupling for the key carbon-carbon bond forming step, and employ this chemistry for the expedient synthesis of other unnatural tyrosine derivatives.
Interferon-Free Hepatitis C Treatment before and after Liver Transplantation: The Role of HCV Drug Resistance.
Review
New
Samuel et al., Villejuif, France. In Viruses, Sep 2015
For patients infected with genotype 1, first generation NS3/4A protease inhibitors (PIs), boceprevir (BOC) or telaprevir (TVR), associated with PEG-IFN and RBV for 48 weeks have increased the SVR rates to 60% in non-transplant patients.
Enhancing our understanding of current therapies for hepatitis C virus (HCV).
Review
New
Chung et al., Boston, United States. In Curr Hiv/aids Rep, Mar 2015
Telaprevir (TVR) and boceprevir (BOC) were the first DAAs introduced for treatment of genotype 1 HCV in 2011; when used in combination with pegylated interferon (pegIFN) and ribavirin (RBV), these protease inhibitors improved efficacy in patients with chronic HCV infection compared to the traditional dual therapy.
Boceprevir and telaprevir for chronic genotype 1 hepatitis C virus infection. A systematic review and meta-analysis.
Review
Chávez-Tapia et al., Cuernavaca, Mexico. In Ann Hepatol, 2015
AIM: Assess benefits and harms of boceprevir (BOC) and telaprevir (TLV) in treatment of genotype 1 HCV infection, and identifying subgroups with most benefit.
Pyrrole-Imidazole Polyamides: Manual Solid-Phase Synthesis.
Burley et al., Glasgow, United Kingdom. In Curr Protoc Nucleic Acid Chem, 2014
The protocol entails solution-phase synthesis of the Boc-protected pyrrole (Py) and imidazole (Im) carboxylic acid building blocks.
[New direct-acting antiviral agents for the treatment of chronic hepatitis C in 2014].
Review
Manns et al., Hannover, Germany. In Internist (berl), 2014
In 2011, the first protease inhibitors boceprevir (BOC) and telaprevir (TLV) were approved, which still need to be combined with pegylated interferon α (PEG-IFN α) and ribavirin (RBV) and are used only in patients with genotype 1.
New agents for the treatment of hepatitis C in patients co-infected with HIV.
Review
Rockstroh et al., Bucureşti, Romania. In Ther Adv Infect Dis, 2013
Pilot trials evaluating the efficacy and safety of the first licensed hepatitis C virus (HCV) protease inhibitors (PIs), boceprevir (BOC) and telaprevir (TVR), for the treatment of genotype 1 infection in HCV/HIV co-infected patients revealed similar results as in HCV mono-infected patients.
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation.
GeneRIF
Charron et al., Montréal, Canada. In Dev Cell, 2011
Genetic loss-of-function of GAS1, Cdon and BOC in SHH is associated with defective cell proliferation.
Boc modifies the holoprosencephaly spectrum of Cdo mutant mice.
GeneRIF
Krauss et al., New York City, United States. In Dis Model Mech, 2011
Cdo;Boc double mutants on a largely Cdo-resistant genetic background have lobar holoprosencephaly.
All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
GeneRIF
Leahy et al., Baltimore, United States. In J Biol Chem, 2010
Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner
Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc.
GeneRIF
Charron et al., Montréal, Canada. In J Neurosci, 2010
Boc receptor is required for segregation of ipsilateral axons at the optic chiasm and, conversely, Boc expression in contralateral retinal ganglion cells prevents their axons from crossing the optic chiasm.
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla.
Impact
Leahy et al., Baltimore, United States. In Nature, 2008
Drosophila Ihog and its vertebrate homologues CDO and BOC contain multiple immunoglobulin and fibronectin type III (FNIII) repeats, and the first FNIII repeat of Ihog binds Drosophila HhN in a heparin-dependent manner.
Proline-catalysed Mannich reactions of acetaldehyde.
Impact
List et al., Mülheim an der Ruhr, Germany. In Nature, 2008
Here we show that acetaldehyde is a powerful nucleophile in asymmetric, proline-catalysed Mannich reactions with N-tert-butoxycarbonyl (N-Boc)-imines, yielding beta-amino aldehydes with extremely high enantioselectivities-desirable products as drug intermediates and in the synthesis of other biologically active molecules.
Emerging rules for subunit-based, multiantigenic, multistage chemically synthesized vaccines.
Review
Impact
Patarroyo et al., Bogotá, Colombia. In Acc Chem Res, 2008
Chemically synthesized approximately 20-mer peptides, covering all the P. falciparum malaria proteins involved in red blood cell (RBC) invasion were synthesized by the classical t-Boc technology (based on synthetic SPf66 antimalarial vaccine information for identifying targets) and assayed in a highly sensitive, specific, and robust test for detecting receptor-ligand interactions between high-activity binding peptides (HABPs) and RBCs.
Differential screening identifies transcripts with depot-dependent expression in white adipose tissues.
GeneRIF
Smas et al., Toledo, United States. In Bmc Genomics, 2007
Boc expression increases in subcutaneous white adipose tissue and decreases in intra-abdominal epididymal white adipocytes in obese mice.
Boc is a receptor for sonic hedgehog in the guidance of commissural axons.
Impact
GeneRIF
McConnell et al., Stanford, United States. In Nature, 2006
data suggest that Boc is essential as a receptor for Shh in commissural axon guidance
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
Impact
Beachy et al., Baltimore, United States. In Cell, 2006
Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
More papers using Boc antibodies
Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix
Supplier
Slack Barbara E et al., In BMC Cell Biology, 1997
... Decanoyl-arg-val-lys-arg-chloromethylketone (Dec-RVKR-CMK) and [(2R, 4R 5S)-2-Benzyl-5-(Boc-amino)-4-hydroxy-6-phenyl-hexanoyl]-Leu-Phe-NH2 (L-685,458) were purchased from Bachem Bioscience (King of Prussia, ...
The Tlg SNARE complex is required for TGN homotypic fusion
Supplier
Fuller Robert S. et al., In The Journal of Cell Biology, 1991
... Boc-Leu-Lys-Arg-7-amino-4-methylcoumarin (LKR-AMC) was from Bachem and Ala-Pro-AMC (AP-AMC) was ...
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