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Natriuretic peptide B

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ANP, AGE, CAN, C-reactive protein
Papers using BNP antibodies
Streptavidin-Functionalized Three-Dimensional Ordered Nanoporous Silica Film for Highly Efficient Chemiluminescent Immunosensing
Katare Rajesh Gopalrao, In PLoS ONE, 2007
... BNP was obtained from GenScript, New Jersey, USA ...
Papers on BNP
Effects of new generation cacc ano1 inhibitors on slow waves in the gastrointestinal tract.
Ward et al., Reno, United States. In Br J Pharmacol, Feb 2016
The purpose of this study was to (i) examine the effects of these Ano1 inhibitors on gastric and intestinal pacemaker activity, (ii) compare the effects of these inhibitors with the more classical CaCC inhibitor, NPPB, (ii) examine the mode of action of these compounds on the waveform of pacemaker activity and (iii) compare differences in the sensitivity between gastric and intestinal pacemaker activity to these CaCC Ano1 inhibitors.
Interleukin-10 Deficiency Aggravates Angiotensin II-induced Cardiac Remodeling in Mice.
Park et al., Taegu, South Korea. In Life Sci, Feb 2016
Plasma levels of brain natriuretic peptide (BNP) and gene expression of BNP in the heart were increased by IL-10 deficiency or angiotensin II, and plasma BNP levels were further increased by IL-10 deficiency with angiotensin II.
Association between the N-terminal plasma brain natriuretic peptide levels or elevated left ventricular filling pressure and thromboembolic risk in patients with non-valvular atrial fibrillation.
Cha et al., Pusan, South Korea. In J Cardiol, Feb 2016
BACKGROUND: We aimed to investigate the role of brain natriuretic peptide (BNP) levels and left ventricular (LV) filling pressures in thromboembolic risk in patients with non-valvular atrial fibrillation (AF).
LCZ696 (Valsartan/Sacubitril) - A Possible New Treatment for Hypertension and Heart Failure.
Grimm et al., Århus, Denmark. In Basic Clin Pharmacol Toxicol, Jan 2016
The aim of this MiniReview was to introduce the newly invented dual-acting drug valsartan/sacubitril (LCZ696), which combines an angiotensin receptor blocker (valsartan) with sacubitril, a specific inhibitor of the neutral endopeptidase (NEP) that degrades vasoactive peptides, including natriuretic peptides ANP and BNP, but also glucagon, enkephalins and bradykinin, among others.
Cardiac biomarkers in children with congenital heart disease.
Senzaki et al., Asahikawa, Japan. In World J Pediatr, Nov 2015
DATA SOURCES: We reviewed cardiac biomarkers-specifically focusing on troponin as a biomarker of myocardial damage, amino-terminal procollagen type III peptide (PIIIP) as a biomarker of myocardial fibrosis and stromal remodeling, and B-type natriuretic peptide (BNP)/N-terminal proBNP as biomarkers of cardiac load and heart failure, by introducing relevant publications, including our own, on pediatric CHD patients as well as adults.
B-type Natriuretic Peptide circulating forms: Analytical and bioactivity issues.
Richards et al., Christchurch, New Zealand. In Clin Chim Acta, Sep 2015
B-type Natriuretic Peptide (BNP), A-type and C-type Natriuretic Peptides (ANP and CNP) comprise a family of peptides that retain a common ring structure and conserved amino acid sequences.
Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial.
EXAMINE Investigators et al., Vandœuvre-lès-Nancy, France. In Lancet, Jun 2015
The post-hoc analyses were of cardiovascular death and hospital admission for heart failure, assessed by history of heart failure and brain natriuretic peptide (BNP) concentration at baseline.
Correlation between rs198388 and rs198389 polymorphismsin brainnatriuretic peptide (NPPB) gene and susceptibility to congenital heart diseases in a Chinese population.
Ying et al., Hangzhou, China. In Int J Clin Exp Med, 2014
OBJECTIVE: We discussed the correlation between SNP loci (rs198389 and rs198388) in brain natriuretic peptide gene (NPPB) and susceptibility to congenital heart diseases (CHD).
The utility of biomarker risk prediction score in patients with chronic heart failure.
Kruzliak et al., Ukraine. In Int J Clin Exp Med, 2014
Circulating levels of NT-pro brain natriuretic peptide (NT-pro-BNP), galectin-3, high-sensitivity C-reactive protein (hs-CRP), osteoprotegerin and its soluble receptor sRANKL, osteopontin, osteonectin, adiponectin, endothelial apoptotic microparticles (EMPs) and mononuclear progenitor cells (MPCs) were measured at baseline.
[The involvement of galectin-3 in heart failure].
Donica et al., In Postepy Hig Med Dosw (online), 2014
Currently, only natriuretic peptides, especially type B natriuretic peptides (BNP) and N-terminal fragment of pro-BNP (NT-proBNP) have been fully approved biomarkers employed in diagnosing HF.
Endocytosis and Trafficking of Natriuretic Peptide Receptor-A: Potential Role of Short Sequence Motifs.
Pandey, New Orleans, United States. In Membranes (basel), 2014
Cardiac hormones, atrial and brain natriuretic peptides (ANP and BNP) bind to guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) and elicit the generation of intracellular second messenger cyclic guanosine 3',5'-monophosphate (cGMP), which lowers blood pressure and incidence of heart failure.
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
SOLSTICE Investigators et al., Durham, United States. In Lancet, 2014
Efficacy outcomes were high-sensitivity C-reactive protein (hsCRP) and B-type natriuretic peptide (BNP) concentrations at 72 h and 12 weeks, and troponin I area under the curve (AUC) over 72 h.
The cells and circuitry for itch responses in mice.
Hoon et al., Bethesda, United States. In Science, 2013
Here, we show that the neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and found that Nppb(-/-) mice selectively lose almost all behavioral responses to itch-inducing agents.
Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial.
ASTRONAUT Investigators and Coordinators et al., Chicago, United States. In Jama, 2013
Eligible patients were 18 years or older with left ventricular ejection fraction (LVEF) 40% or less, elevated natriuretic peptides (brain natriuretic peptide [BNP] ≥ 400 pg/mL or N -terminal pro-BNP [NT-proBNP] ≥ 1600 pg/mL), and signs and symptoms of fluid overload.
Efficacy and effect on plasma B-type natriuretic peptide concentration of losartan-hydrochlorothiazide for hypertension uncontrolled by losartan-based therapy: subanalysis of a Multicentre Prospective Observational Study.
Kubara et al., Fukuoka, Japan. In Arzneimittelforschung, 2012
In 12 patients with baseline plasma BNP concentration >/=20 pg/mL, BNP decreased from 78.3+/-18.8 pg/mL to 57.3+/-17.7 pg/mL (p<0.01).
Role of N-terminal pro-brain natriuretic peptide in detecting clinically significant cardiac involvement in systemic sclerosis patients.
Ong et al., Milano, Italy. In Clin Exp Rheumatol, 2012
Suggest NTproBNP peptide may be a surrogate marker for cardiac involvement in systemic sclerosis.
[Brain natriuretic peptide (BNP) level predicts long term ventricular arrhythmias in patients with moderate to severe left ventricular dysfunction].
Amit et al., Ashqelon, Israel. In Harefuah, 2012
Of patients with ischemic heart disease & left ventricular dysfunction, with an implantable cardioverter defibrillator, those with BNP levels in the highest quartile had significantly more arrhythmic events than did those at the lower three quartiles
Diastolic function in pregnant patients with cardiac symptoms.
Briller et al., Chicago, United States. In Hypertens Pregnancy, 2011
levels may identify elevated LV filling pressures in symptomatic pregnant patients
Correlation between serum concentrations of B-type natriuretic peptide and albumin in patients with chronic congestive heart failure.
Takatsu et al., Amagasaki, Japan. In Int Heart J, 2011
predicts major adverse cardiac events in congestive heart failure independent of albumin
Novel and conventional biomarkers for prediction of incident cardiovascular events in the community.
Wang et al., Malmö, Sweden. In Jama, 2009
Participants underwent measurement of C-reactive protein (CRP), cystatin C, lipoprotein-associated phospholipase 2, midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide, and N-terminal pro-B-type natriuretic peptide (N-BNP) and underwent follow-up until 2006 using the Swedish national hospital discharge and cause-of-death registers and the Stroke in Malmö register for first cardiovascular events (myocardial infarction, stroke, coronary death).
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