Effects of new generation cacc ano1 inhibitors on slow waves in the gastrointestinal tract.
Reno, United States. In Br J Pharmacol, Feb 2016
The purpose of this study was to (i) examine the effects of these Ano1 inhibitors on gastric and intestinal pacemaker activity, (ii) compare the effects of these inhibitors with the more classical CaCC inhibitor, NPPB, (ii) examine the mode of action of these compounds on the waveform of pacemaker activity and (iii) compare differences in the sensitivity between gastric and intestinal pacemaker activity to these CaCC Ano1 inhibitors.
LCZ696 (Valsartan/Sacubitril) - A Possible New Treatment for Hypertension and Heart Failure.
Århus, Denmark. In Basic Clin Pharmacol Toxicol, Jan 2016
The aim of this MiniReview was to introduce the newly invented dual-acting drug valsartan/sacubitril (LCZ696), which combines an angiotensin receptor blocker (valsartan) with sacubitril, a specific inhibitor of the neutral endopeptidase (NEP) that degrades vasoactive peptides, including natriuretic peptides ANP and BNP, but also glucagon, enkephalins and bradykinin, among others.
Cardiac biomarkers in children with congenital heart disease.
Asahikawa, Japan. In World J Pediatr, Nov 2015
DATA SOURCES: We reviewed cardiac biomarkers-specifically focusing on troponin as a biomarker of myocardial damage, amino-terminal procollagen type III peptide (PIIIP) as a biomarker of myocardial fibrosis and stromal remodeling, and B-type natriuretic peptide (BNP)/N-terminal proBNP as biomarkers of cardiac load and heart failure, by introducing relevant publications, including our own, on pediatric CHD patients as well as adults.
The utility of biomarker risk prediction score in patients with chronic heart failure.
Ukraine. In Int J Clin Exp Med, 2014
Circulating levels of NT-pro brain natriuretic peptide (NT-pro-BNP), galectin-3, high-sensitivity C-reactive protein (hs-CRP), osteoprotegerin and its soluble receptor sRANKL, osteopontin, osteonectin, adiponectin, endothelial apoptotic microparticles (EMPs) and mononuclear progenitor cells (MPCs) were measured at baseline.
[The involvement of galectin-3 in heart failure].
In Postepy Hig Med Dosw (online), 2014
Currently, only natriuretic peptides, especially type B natriuretic peptides (BNP) and N-terminal fragment of pro-BNP (NT-proBNP) have been fully approved biomarkers employed in diagnosing HF.
The cells and circuitry for itch responses in mice.
Bethesda, United States. In Science, 2013
Here, we show that the neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and found that Nppb(-/-) mice selectively lose almost all behavioral responses to itch-inducing agents.
Novel and conventional biomarkers for prediction of incident cardiovascular events in the community.
Malmö, Sweden. In Jama, 2009
Participants underwent measurement of C-reactive protein (CRP), cystatin C, lipoprotein-associated phospholipase 2, midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide, and N-terminal pro-B-type natriuretic peptide (N-BNP) and underwent follow-up until 2006 using the Swedish national hospital discharge and cause-of-death registers and the Stroke in Malmö register for first cardiovascular events (myocardial infarction, stroke, coronary death).