Aging: past, present and future
In Cell Cycle, 2008
... were as follows: β-actin (Sigma-Aldrich, #A5441); Cav-1 (BD Transduction Laboratories, #610406); Beclin1 (Novus Biologicals, #NBP1–00085); BNIP3 (Abcam, #ab10433); Cathepsin B (FL-339) (Santa ...
BNIP3 promotes calcium and calpain-dependent cell death.
Miami, United States. In Life Sci, Jan 2016
Hypoxia-acidosis was demonstrated to activate the pro-apoptotic Bcl-2 protein BNIP3 which initiated opening of the mitochondrial permeability transition pore and cell death in the absence of caspase activation.
Tumor suppressor functions of BNIP3 and mitophagy.
Chicago, United States. In Autophagy, Nov 2015
Our recent work adds to this appreciation by showing that the mitophagy receptor BNIP3 functions as a tumor suppressor in mammary tumorigenesis and also as a prognostic indicator of progression to metastasis in certain sub-types of human breast cancer.
The divergent roles of autophagy in ischemia and preconditioning.
Suzhou, China. In Acta Pharmacol Sin, Apr 2015
Preconditioning or lethal ischemia may trigger autophagy via multiple signaling pathways involving endoplasmic reticulum (ER) stress, AMPK/TSC/mTOR, Beclin 1/BNIP3/SPK2, and FoxO/NF-κB transcription factors, etc. Autophagy then interacts with apoptotic and necrotic signaling pathways to regulate cell death.
The role of STAT3 in autophagy.
Hangzhou, China. In Autophagy, 2014
For example, nuclear STAT3 fine-tunes autophagy via the transcriptional regulation of several autophagy-related genes such as BCL2 family members, BECN1, PIK3C3, CTSB, CTSL, PIK3R1, HIF1A, BNIP3, and microRNAs with targets of autophagy modulators.
Mechanisms of mitophagy.
Bethesda, United States. In Nat Rev Mol Cell Biol, 2011
Mitophagy, the specific autophagic elimination of mitochondria, has been identified in yeast, mediated by autophagy-related 32 (Atg32), and in mammals during red blood cell differentiation, mediated by NIP3-like protein X (NIX; also known as BNIP3L).