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Bone morphogenetic protein receptor, type IA

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BMPR-IB, BMP4, Smad1, CAN, V1a
Papers using BMPR1A antibodies
Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum
Yan B et al., In Cell Death & Disease, 2005
... PLA including rabbit antibodies to BMP4 (N-term AP1715a), BMPR1A (C-term, AP2004b) and BMPR2 (N-term, AP2006a) were purchased from Abgent (San Diego, CA, USA) ...
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan–Riley–Ruvalcaba syndromes
Shemanko C. S. et al., In In Vitro Cellular & Developmental Biology. Animal, 2000
... Goat and rabbit anti BMPR1A antibodies were purchased from Santa Cruz (Santa Cruz, CA) and Abgent (Biolynx, San Diego, CA), ...
Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin
Gussoni Emanuela et al., In The Journal of Cell Biology, 1998
... CD133-PE (Miltenyi Biotec), anti-CD45-PE (Miltenyi Biotec), rat IgG-PE (BD Biosciences), anti-ABCG2 (Stem Cell Technologies), or anti-BMPR1a (Santa Cruz Biotechnology, Inc.) ...
Papers on BMPR1A
Pax8 plays a pivotal role in regulation of cardiomyocyte growth and senescence.
Geng et al., Wenzhou, China. In J Cell Mol Med, Feb 2016
Bone morphogenetic protein receptor IA (ALK3) mediates the development of ventricular septal defect (VSD).
Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation.
Perreault et al., Sherbrooke, Canada. In Int J Cancer, Feb 2016
In order to identify the role of mesenchymal Bmp signaling on the microenvironment and its impact on colonic mucosa, a mouse model was generated with suppression of Bmp signaling exclusively in myofibroblasts (Bmpr1a (ΔMES) ).
Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation.
Park et al., Seoul, South Korea. In Mod Pathol, Feb 2016
TWSG1 bound to BMP4 and inhibited BMP4-binding activity to BMPR-II.
Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development.
Schambony et al., Erlangen, Germany. In Bmc Dev Biol, Dec 2015
BMP receptors Ia and Ib, also known as ALK3 and ALK6 respectively, are the most common type I receptors that likely mediate most BMP signaling events.
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
Morrell et al., Basel, Switzerland. In Nat Med, Jul 2015
Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH).
Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing.
Houlston et al., London, United Kingdom. In J Clin Oncol, Mar 2015
PATIENTS AND METHODS: To quantify the impact of germline mutation to familial CRC, we sequenced the mismatch repair genes (MMR) APC, MUTYH, and SMAD4/BMPR1A in 626 early-onset familial CRC cases ascertained through a population-based United Kingdom national registry.
Bmpr1a Signaling in Cartilage Development and Endochondral Bone Formation.
Feng et al., Chengdu, China. In Vitam Horm, 2014
The type IA bone morphogenetic protein receptor (Bmpr1a), encoded by 11 exons and spanning about 40 kb on chromosome 14 in mice and chromosome 10 in human (Derynck & Feng, 1997; Mishina, Hanks, Miura, Tallquist, & Behringer, 2002), is an essential receptor for BMP signaling.
The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension.
Morrell et al., Cambridge, United Kingdom. In Glob Cardiol Sci Pract, 2014
The genetics of pulmonary arterial hypertension (PAH) strongly implicates loss-of-function of the bone morphogenetic protein type II receptor (BMPR-II) signalling pathway and moreover implicates the endothelial cell as a central cell type involved in disease initiation.
Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility.
Bogunovic et al., New York City, United States. In Cell, 2014
They change the pattern of smooth muscle contractions by secreting bone morphogenetic protein 2 (BMP2), which activates BMP receptor (BMPR) expressed by enteric neurons.
Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.
Kim et al., Boston, United States. In Cell, 2014
Gain- and loss-of-function experiments showed that BMP4-Bmpr1a signaling triggers calcineurin/NFATc1-dependent expression of thrombospondin-1 (Tsp1) in lung endothelial cells to drive alveolar lineage-specific BASC differentiation.
Genetics and the molecular pathogenesis of pulmonary arterial hypertension.
Morrell et al., In Curr Hypertens Rep, 2013
Mutations in the bone morphogenetic protein type II receptor (BMPR-II) gene (BMPR2) have been recognized to cause heritable PAH (HPAH).
The transforming growth factor-β-bone morphogenetic protein type signalling pathway in pulmonary vascular homeostasis and disease.
Morrell et al., Cambridge, United Kingdom. In Exp Physiol, 2013
Germ-line mutations in the bone morphogenetic protein type II receptor (BMPR2; BMPR-II) gene, a transforming growth factor-β (TGFβ) receptor superfamily member, cause the majority of cases of heritable pulmonary arterial hypertension (PAH).
Regulation of systemic iron homeostasis.
Finberg, Durham, United States. In Curr Opin Hematol, 2013
RECENT FINDINGS: The bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 play key, nonredundant roles in mediating hepcidin synthesis through the BMP signaling pathway.
Development of a potent and ALK2 selective bone morphogenetic protein receptor (BMP) inhibitor
Hopkins et al., Bethesda, United States. In Unknown Journal, 2013
This medicinal chemistry effort led to the identification of a potent and selective compound for ALK2 versus ALK3.
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.
Tseng et al., Boston, United States. In Nature, 2013
Genetic ablation of the type 1A BMP receptor (Bmpr1a) in brown adipogenic progenitor cells leads to a severe paucity of cBAT.
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength.
Croucher et al., Sheffield, United Kingdom. In Proc Natl Acad Sci U S A, 2012
BMPR1A fusion protein stimulates osteoblastic bone formation and decreases bone resorption, which leads to an increase in bone mass, and offers a promising unique alternative for the treatment of bone-related disorders.
Oligomeric interactions of TGF-β and BMP receptors.
Henis et al., Tel Aviv-Yafo, Israel. In Febs Lett, 2012
generation of TGF-beta and BMP receptor homo- and hetero-oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines [review]
Promiscuity and specificity in BMP receptor activation.
Nickel et al., Würzburg, Germany. In Febs Lett, 2012
analysis of promiscuity and specificity in BMP receptor activation [review]
Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis.
Kalluri et al., Boston, United States. In Nat Med, 2012
activin-like kinase 3 (Alk3) is elevated early in diseased kidneys after injury..its deletion leads to enhanced Smad3 signaling, epithelial damage and fibrosis, suggesting a protective role for Alk3-mediated signaling in the kidney
Expression of BMPRIA on human thymic NK cell precursors: role of BMP signaling in intrathymic NK cell development.
Vicente et al., Madrid, Spain. In Blood, 2012
Results suggest that BMPRIA expression identifies thymic NK cell precursors and that BMP signaling is relevant for NK cell differentiation in the thymus.
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