Identification and characterization of miRNAs in the ovaries of a highly prolific sheep breed.
Beijing, China. In Anim Genet, Dec 2015
Among the target genes, intracellular transducers (SMAD1, SMAD4, SMAD5 and SMAD9) and bone morphogenetic protein (BMP) receptors (BMPR1B and BMPR2) were involved in the transforming growth factor β (TGFβ) signaling pathway in the reproductive axis, and the most significant GO terms were intracellular part (GO:0044424), binding (GO:0005488) and biological_process (GO:0008150) for cellular component, molecular function and biological process respectively.
Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases.
Tokyo, Japan. In Front Cell Dev Biol, 2013
ARID3B, BAK1, BCL2, BMPR1B, ERBB2, FGFR2, IL6R, MUC1, SITR7, Smoothened, STAT3, TET2, and TP53 are representative miR-125b targets.
Oligomeric interactions of TGF-β and BMP receptors.
Tel Aviv-Yafo, Israel. In Febs Lett, 2012
generation of TGF-beta and BMP receptor homo- and hetero-oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines [review]
Genetic aspects of reproduction in sheep.
Blacksburg, United States. In Reprod Domest Anim, 2008
Mutations in several genes associated with the transforming growth factor beta superfamily (BMPRIB, GDF9 and sex-linked BMP15) can increase ovulation rates by 0.7-1.5 ova in heterozygous ewes.
Mouse genetic models of cleft lip with or without cleft palate.
Vancouver, Canada. In Birth Defects Res A Clin Mol Teratol, 2008
Combining the results of chromosomal linkage studies of unidentified human CLP genes with insights from the mouse models, the following previously unexamined genes are identified as strong candidate genes for causative roles in human nonsyndromic CLP: BMP4, BMPR1B, TFAP2A, SOX4, WNT9B, WNT3, and SP8.
BMPing off glioma stem cells.
Los Angeles, United States. In Cancer Cell, 2008
This latter effect is the result of epigenetic silencing of the BMP receptor 1B (BMPR1B).
Heritable Pulmonary Arterial Hypertension
Seattle, United States. In Unknown Journal, 2002
Most heritable PAH (75%) is caused by a pathogenic variant in BMPR2; pathogenic variants in other genes (i.e., ACVRL1, KCNK3, CAV1, SMAD9, BMPR1B,) are considerably less common (1-3%).