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Bone morphogenetic protein receptor, type IB

BMPR-IB, BMPR1B, ALK6
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: BMPR1A, BMP4, Smad1, CAN, TGF-beta
Papers using BMPR-IB antibodies
Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
Supplier
Di Chen et al., In The Journal of Cell Biology, 1996
were used to drive truncated BMPR-IB expression in transgenic mice ...
Papers on BMPR-IB
Low expression of BMPRIB indicates poor prognosis of breast cancer and is insensitive to taxane-anthracycline chemotherapy.
New
Ma et al., Tianjin, China. In Oncotarget, Jan 2016
UNASSIGNED: Bone morphogenetic protein receptor type IB (BMPRIB) is one osteogenesis factor, which function in breast cancer has been rarely explored until recently.
The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders.
New
Tomizuka et al., Machida, Japan. In Sci Rep, Dec 2015
Both BMPRIA and BMPRIB are type I BMP receptors, and while BMPRIA-Fc has been reported to have bone-increasing properties, there have been no investigations concerning the biological functions of BMPRIB-Fc.
Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development.
New
Schambony et al., Erlangen, Germany. In Bmc Dev Biol, Dec 2015
BMP receptors Ia and Ib, also known as ALK3 and ALK6 respectively, are the most common type I receptors that likely mediate most BMP signaling events.
Identification and characterization of miRNAs in the ovaries of a highly prolific sheep breed.
New
Li et al., Beijing, China. In Anim Genet, Dec 2015
Among the target genes, intracellular transducers (SMAD1, SMAD4, SMAD5 and SMAD9) and bone morphogenetic protein (BMP) receptors (BMPR1B and BMPR2) were involved in the transforming growth factor β (TGFβ) signaling pathway in the reproductive axis, and the most significant GO terms were intracellular part (GO:0044424), binding (GO:0005488) and biological_process (GO:0008150) for cellular component, molecular function and biological process respectively.
Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.
New
Mythreye et al., Durham, United States. In Neoplasia, Nov 2015
We find that GDF2 can robustly activate the SMAD1/5 signaling axis by increasing complex formation between the type I receptor serine threonine kinases activin receptor-like kinase (ALK) 3 and ALK6 and the type II receptor serine threonine kinase BMPRII.
Bone morphogenetic protein 4 and bone morphogenetic protein receptor expression in the pituitary gland of adult dogs in healthy condition and with ACTH-secreting pituitary adenoma.
New
Hara et al., Musashino, Japan. In Domest Anim Endocrinol, Oct 2015
However, there were no statistically significant differences between samples with respect to the messenger RNA expression levels of the receptors BMPRIA, BMPRIB, and BMPRII.
EFFECT OF SOMATOSTATIN ON DENTAL PULP STEM CELLS.
New
Palmieri et al., Monza, Italy. In J Biol Regul Homeost Agents, Jul 2015
BMPR1B and BMPR2).
Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases.
Review
Katoh, Tokyo, Japan. In Front Cell Dev Biol, 2013
ARID3B, BAK1, BCL2, BMPR1B, ERBB2, FGFR2, IL6R, MUC1, SITR7, Smoothened, STAT3, TET2, and TP53 are representative miR-125b targets.
Oligomeric interactions of TGF-β and BMP receptors.
GeneRIF
Henis et al., Tel Aviv-Yafo, Israel. In Febs Lett, 2012
generation of TGF-beta and BMP receptor homo- and hetero-oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines [review]
Odontogenic ameloblasts-associated protein (ODAM), via phosphorylation by bone morphogenetic protein receptor type IB (BMPR-IB), is implicated in ameloblast differentiation.
GeneRIF
Park et al., Seoul, South Korea. In J Cell Biochem, 2012
the BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization
A covalently dimerized recombinant human bone morphogenetic protein-15 variant identifies bone morphogenetic protein receptor type 1B as a key cell surface receptor on ovarian granulosa cells.
GeneRIF
Ritvos et al., Helsinki, Finland. In Endocrinology, 2012
BMP15 uses preferentially BMPR1B as its type I receptor, suggesting an important role for the BMPR1B receptor in human female fertility
Missense mutations of the BMPR1B (ALK6) gene in childhood idiopathic pulmonary arterial hypertension.
GeneRIF
Nakanishi et al., Tokorozawa, Japan. In Circ J, 2011
Suggest that BMPR1B mutations are associated with the pathogenesis of childhood idiopathic pulmonary arterial hypertension.
Variation in BMPR1B, TGFRB1 and BMPR2 and control of dizygotic twinning.
GeneRIF
Painter et al., Brisbane, Australia. In Twin Res Hum Genet, 2011
Variation in BMPR1B is associated with dizygotic twinning.
[Progress in exploring genes for high fertility in ewes].
Review
Cao et al., Beijing, China. In Yi Chuan, 2011
Among them, BMPR-IB, BMP-15, and GDF-9 are most distinguishing.
Genetic aspects of reproduction in sheep.
Review
Notter, Blacksburg, United States. In Reprod Domest Anim, 2008
Mutations in several genes associated with the transforming growth factor beta superfamily (BMPRIB, GDF9 and sex-linked BMP15) can increase ovulation rates by 0.7-1.5 ova in heterozygous ewes.
Mouse genetic models of cleft lip with or without cleft palate.
Review
Harris et al., Vancouver, Canada. In Birth Defects Res A Clin Mol Teratol, 2008
Combining the results of chromosomal linkage studies of unidentified human CLP genes with insights from the mouse models, the following previously unexamined genes are identified as strong candidate genes for causative roles in human nonsyndromic CLP: BMP4, BMPR1B, TFAP2A, SOX4, WNT9B, WNT3, and SP8.
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
Impact
Fine et al., Bethesda, United States. In Cancer Cell, 2008
We now demonstrate that both bone morphogenetic protein (BMP)-mediated and ciliary neurotrophic factor (CNTF)-mediated Jak/STAT-dependent astroglial differentiation is impaired due to EZH2-dependent epigenetic silencing of BMP receptor 1B (BMPR1B) in a subset of glioblastoma TICs.
BMPing off glioma stem cells.
Impact
Kornblum et al., Los Angeles, United States. In Cancer Cell, 2008
This latter effect is the result of epigenetic silencing of the BMP receptor 1B (BMPR1B).
Heritable Pulmonary Arterial Hypertension
Review
Phillips et al., Seattle, United States. In Unknown Journal, 2002
Most heritable PAH (75%) is caused by a pathogenic variant in BMPR2; pathogenic variants in other genes (i.e., ACVRL1, KCNK3, CAV1, SMAD9, BMPR1B,) are considerably less common (1-3%).
Characterization of type I receptors for transforming growth factor-beta and activin.
Impact
Heldin et al., Uppsala, Sweden. In Science, 1994
The type II receptors for TGF-beta and activin are transmembrane serine-threonine kinases; a series of related receptors, denoted activin receptor-like kinase (ALK) 1 to 5, have recently been identified, and ALK-6 is described here.
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