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Bone morphogenetic protein 5

BMP5, bone morphogenetic protein 5
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BMP4, BMP-6, BMP-7, TGF-beta, HAD
Papers using BMP5 antibodies
Tissue culture of autonomic neurons.
Supplier
Lein Pamela J et al., In BMC Neuroscience, 1990
... Affinity-purified polyclonal antibody (Ab) specific for BMP-5, the blocking peptide for the BMP-5 Ab, and the recombinant human BMP-RIA-Fc chimera were purchased from Research Diagnostics (Flanders, NJ) ...
Papers on BMP5
Integrative transcriptomics-based identification of cryptic drivers of taxol-resistance genes in ovarian carcinoma cells: Analysis of the androgen receptor.
New
Chao et al., Anyang, China. In Oncotarget, Oct 2015
AR silencing also downregulated the expression of prominent txr gene candidates (including abcb1, abcb6, abcg2, bmp5, fat3, fgfr2, h1f0, srcrb4d, and tmprss15).
Effect of early addition of bone morphogenetic protein 5 (BMP5) to embryo culture medium on in vitro development and expression of developmentally important genes in bovine preimplantation embryos.
New
Barrera et al., San Miguel de Tucumán, Argentina. In Theriogenology, Oct 2015
Previous studies have reported that bone morphogenetic protein 5 (BMP5) is differentially expressed in the isthmus of bovine oviducts and it is present in the oviductal fluid.
Gene profile of soluble growth factors involved in angiogenesis, in an adipose-derived stromal cell/endothelial cell co-culture, 3D gel model.
New
Lin et al., Chengdu, China. In Cell Prolif, Aug 2015
Over this time in ECs, genes coding for VEGFA/B, IGF-1, HIF-1α, FGF-1/-2 and BMP-5/-7 significantly increased.
INSULIN ACTIVITY ON DENTAL PULP STEM CELL DIFFERENTIATION: AN IN VITRO STUDY.
New
Palmieri et al., Monza, Italy. In J Biol Regul Homeost Agents, Jul 2015
Significantly down-regulated genes were BMP4, BMP7 and TGFBR2 after 24 h of treatment and BMP5 and BMP7 after 48 h.
Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma.
New
Fu et al., Wuhan, China. In Acta Biochim Biophys Sin (shanghai), Jul 2015
In this study, the mRNA levels of BMP family members in NSCLC tissues were analyzed and results showed that the mRNA levels of BMP5 and BMP7 were significantly down-regulated and up-regulated, respectively, in tumor tissues compared with those in the corresponding noncancerous tissues.
Bioinformatic identification of connective tissue growth factor as an osteogenic protein within skeletal muscle.
Park et al., Philadelphia, United States. In Physiol Rep, 2015
GEO dataset analysis identified BMP5, COL1A2, CTGF, MGP, MMP2, and SPARC as potential targets for further processing.
Form-deprivation myopia induces decreased expression of bone morphogenetic protein-2, 5 in guinea pig sclera.
Ma et al., Qingdao, China. In Int J Ophthalmol, 2014
Fourteen days after the induction of myopia, significant decreased expressions for BMP-2 and BMP-5 in the posterior sclera of FDM-affected eyes (P<0.05
Lefty-1 alleviates TGF-β1-induced fibroblast-myofibroblast transdifferentiation in NRK-49F cells.
Wu et al., Wuhan, China. In Drug Des Devel Ther, 2014
However, without TGF-β1, Lefty-1 had no effect on Smad3, JNK-3, and BMP-5 activation and fibroblast-myofibroblast transdifferentiation. Taken together, these findings indicate that Lefty-1 can alleviate TGF-β1-mediated activation and the proliferation of fibroblasts.
Genome wide analysis of novel copy number variations duplications/deletions of different epileptic patients in Saudi Arabia.
Al-Qahtani et al., In Bmc Genomics, 2014
Two genes BMP5 and PODXL were located in the predicted duplicated and deleted regions respectively.
Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy.
Tan et al., United States. In Sci Rep, 2014
Of the top 10 genes (fold-change > 10, P < 10(-10)) regulated by metformin plus aspirin, PCDH18, CCL2, RASL11A, FAM111B and BMP5 were down-regulated ≥ 20-fold, while NGFR, NPTX1, C7orf57, MRPL23AS1 and UNC5B were up-regulated ≥ 10-fold.
[Morphological and molecular bases of cardiac development].
Review
Burdan et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2012
Their expression is regulated by various molecules, including transcription (XIN, GATA, MEF, Tbx5, Baf60c, PECAM, tie-2, MEF2) and growth (VEGF, FGF, PDGF) factors, as well as proteins (i.e., dickkopf-1, cerberus, cytotactin, fibrillin, nodal, thrombomodulin, Wnt, bone morphometric ones - BMP2, BMP 4, BMP5, BMP7) and other substances, such as retinoid and folic acid.
Bone morphogenetic protein -4 and -5 in pancreatic cancer--novel bidirectional players.
GeneRIF
Kallioniemi et al., Tampere, Finland. In Exp Cell Res, 2011
Taken together, BMP4 and BMP5 simultaneously inhibit the growth and promote migration and invasion of the same pancreatic cells and thus exhibit a biphasic role with both detrimental and beneficial functions in pancreatic cancer progression
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis.
GeneRIF
Strutz et al., Göttingen, Germany. In J Nephrol, 2011
BMP-5 is expressed in the tubuli of adult kidneys. Its decreased expression in nephrosclerosis along with its regenerative capabilities in HK-2 cells may point to a protective role in hypertensive nephrosclerosis.
Bone morphogenetic protein 5 regulates the number of keratinocyte stem cells from the skin of mice.
GeneRIF
Morris et al., New York City, United States. In J Invest Dermatol, 2011
Bone morphogenetic protein 5 regulates the number of keratinocyte stem cells from the skin of mice.
Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons.
GeneRIF
Brodski et al., Beersheba, Israel. In Mol Cell Neurosci, 2010
Data indicate that locus coeruleus development requires either Bmp5 or Bmp7, and one is able to compensate for the loss of the other.
Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis.
GeneRIF
Loughlin et al., Oxford, United Kingdom. In Bmc Med Genet, 2008
Variability in gene expression of BMP5 may be an important contributor to osteoarthritis genetic susceptibility
Defining the skeletal elements.
Review
Vortkamp, Boston, United States. In Curr Biol, 1997
A recent study of mice carrying different combinations of mutations in the genes for two bone morphogenetic factors (BMPs), BMP5 and GDF5, indicates that BMPs have specific and synergistic functions in the regulation of skeleton development.
The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily.
Impact
Jenkins et al., Stanford, United States. In Cell, 1992
Here we show that the short ear region contains the gene for a TGF beta-related protein called bone morphogenetic protein 5 (Bmp-5).
The bone morphogenetic protein family and osteogenesis.
Review
Wozney, Cambridge, United States. In Mol Reprod Dev, 1992
The BMPs can be divided into subgroups with BMP-2 and BMP-4 being 92% identical, and BMP-5, BMP-6, and BMP-7 being an average of about 90% identical.
Bone morphogenetic proteins.
Review
Wozney, Cambridge, United States. In Prog Growth Factor Res, 1988
Several newly discovered factors, BMP-1, BMP-2 (BMP-2A), BMP-3 (osteogenin), BMP-4 (BMP-2B), BMP-5, BMP-6, BMP-7, and osteoinductive factor (OIF) have been implicated in the BMP process.
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