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Bone morphogenetic protein 4

BMP4, bone morphogenetic protein 4
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using BMP4 antibodies
Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis.
Zernecke Alma, In PLoS ONE, 2009
... Neutralizing antibodies against BMP2 and BMP4 were obtained from LSBio (Seattle, WA, USA) and Abcam (Cambridge, MA, USA), respectively ...
Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung
Keski-Oja Jorma et al., In The Journal of Cell Biology, 1994
... TGF-β2, TGF-β3, fibrillin-1 (H-109), Smad1 (A-4), and BMP-4 (3H2.3)
Papers on BMP4
LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.
Patterson et al., Chapel Hill, United States. In Circ Res, 2012
These data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis.
Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Birchmeier et al., Berlin, Germany. In Proc Natl Acad Sci U S A, 2012
Progenitor cells of the first and second heart fields depend on cardiac-specific transcription factors for their differentiation and Wnt/beta-catenin and Bmp act downstream of Notch/RBPJ at this developmental stage.
Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4.
Grinspan et al., Philadelphia, United States. In J Neuropathol Exp Neurol, 2012
The findings of this study suggested that IUGR results in delayed myelination through the generation of oxidative stress that leads to BMP4 upregulation.
An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud.
Maas et al., Boston, United States. In Plos One, 2011
Pitx homeoprotein family members bind a specific site in the Bmp4 incisor epithelium limb bud enhancer element that is necessary for its activity in vivo.
Common TGFβ2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma.
Sowden et al., Glasgow, United Kingdom. In Mol Vis, 2011
No significant associations were identified between FOXC1, TGFbeta2, and BMP4 alleles and haplotypes and primary open-angle glaucoma.
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