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Bone morphogenetic protein 4
BMP4, bone morphogenetic protein 4
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008] (from
Birchmeier et al., Berlin, Germany. In Proc Natl Acad Sci U S A, 2012
Progenitor cells of the first and second heart fields depend on cardiac-specific transcription factors for their differentiation and Wnt/beta-catenin and Bmp act downstream of Notch/RBPJ at this developmental stage.