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Bone morphogenetic protein 4

BMP4, bone morphogenetic protein 4
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, Smad1, Noggin
Papers using BMP4 antibodies
Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis.
Zernecke Alma, In PLoS ONE, 2009
... Neutralizing antibodies against BMP2 and BMP4 were obtained from LSBio (Seattle, WA, USA) and Abcam (Cambridge, MA, USA), respectively ...
Disruption of LTBP-4 function reduces TGF-β activation and enhances BMP-4 signaling in the lung
Keski-Oja Jorma et al., In The Journal of Cell Biology, 1994
... TGF-β2, TGF-β3, fibrillin-1 (H-109), Smad1 (A-4), and BMP-4 (3H2.3)
Papers on BMP4
CD200 expression in human cultured bone marrow mesenchymal stem cells is induced by pro-osteogenic and pro-inflammatory cues.
Deschaseaux et al., Tours, France. In J Cell Mol Med, Feb 2016
In addition, osteogenic cues generated by bone morphogenetic protein 4 (BMP4) or BMP7 strongly induced CD200 expression.
BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.
Miyazono et al., Uppsala, Sweden. In Stem Cell Reports, Feb 2016
Here, we revisit the roles of BMP-4 using mouse ESCs (mESCs) in naive and primed states.
MicroRNA-378 promotes myogenic differentiation by targeting BMP4.
Qi et al., Yangzhou, China. In Mol Med Report, Feb 2016
The protein levels of bone morphogenetic protein 4 (BMP4), which was among the differentially expressed genes, were decreased following ectopic expression of miRNA‑378.
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
Azim Surani et al., Kōbe, Japan. In Nature, Feb 2016
Consequently, bone morphogenetic protein 4 (BMP4), or ectopic expression of key germline transcription factors Prdm1, Prdm14 and Tfap2c, directly induce PGC-like cells (PGCLCs) in EpiLCs, but not in ES cells.
Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells.
Takahashi et al., Nagasaki, Japan. In Invest Ophthalmol Vis Sci, Feb 2016
Connexin43 and aquaporin1 were expressed in both thin layers, and induced CE-like cells expressed ciliary marker genes, such as cyclinD2, zic1, tgfb2, aldh1a3, wfdc1, otx1, BMP4, and BMP7.
Effect of bone morphogenetic protein-4 on in vitro growth, steroidogenesis and subsequent developmental competence of the oocyte-granulosa cell complex derived from bovine early antral follicles.
Nagano et al., Sapporo, Japan. In Reprod Biol Endocrinol, Dec 2015
Theca-derived BMP-4 may be beneficial to in vitro growth culture of early antral follicle-derived oocyte-granulosa cell complexes (OGCs), which is lacking in theca-derived products.
Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 Genes.
Tirone et al., Roma, Italy. In J Cell Physiol, Dec 2015
Such actions are effected by regulating the expression of several genes, including cyclin D1, BMP4, Id3.
Regulation of human (adrenal) androgen biosynthesis-New insights from novel throughput technology studies.
Flück et al., Bern, Switzerland. In Biochem Pharmacol, Nov 2015
Transcriptome profiling of dissected adrenal zones established a role for BMP4 in androgen synthesis.
Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.
Cowan et al., Basel, Switzerland. In Nat Cell Biol, Aug 2015
We found that GSK3 inhibition and BMP4 treatment rapidly committed pluripotent cells to a mesodermal fate and subsequent exposure to VEGF-A or PDGF-BB resulted in the differentiation of either endothelial or vascular smooth muscle cells, respectively.
Generation of articular chondrocytes from human pluripotent stem cells.
Keller et al., Toronto, Canada. In Nat Biotechnol, Jun 2015
In contrast, chondrocytes specified by BMP4 signaling display characteristics of hypertrophy and give rise to cartilage tissues that initiate the endochondral ossification process in vivo.
Estrogen and female reproductive tract innervation: cellular and molecular mechanisms of autonomic neuroplasticity.
Smith et al., Montevideo, Uruguay. In Auton Neurosci, 2015
In contrast to the uterus, estrogen depletes vaginal autonomic and nociceptive axons, with the latter driven in part by estrogen-induced suppression of BMP4 synthesis.
Bone Morphogenetic Proteins: Inhibitors of Myelination in Development and Disease.
Grinspan, Philadelphia, United States. In Vitam Horm, 2014
BMPs, predominantly BMP4, were increased in animal models of spinal cord injury, stroke, multiple sclerosis, and perinatal white matter injury.
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance.
Rohner-Jeanrenaud et al., Genève, Switzerland. In Front Physiol, 2014
Interestingly, similar results were obtained by adipose tissue-specific overexpression of PR-domain-containing 16 (PRDM16) or BMP4 in mice.
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells.
Brivanlou et al., New York City, United States. In Nat Methods, 2014
In response to BMP4, colonies reproducibly differentiated to an outer trophectoderm-like ring, an inner ectodermal circle and a ring of mesendoderm expressing primitive-streak markers in between.
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.
Batlle et al., Barcelona, Spain. In Nat Cell Biol, 2014
In human tumours, GATA6 competes with β-catenin/TCF4 for binding to a distal regulatory region of the BMP4 locus that has been linked to increased susceptibility to development of CRC.
LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.
Patterson et al., Chapel Hill, United States. In Circ Res, 2012
These data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis.
Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.
Birchmeier et al., Berlin, Germany. In Proc Natl Acad Sci U S A, 2012
Progenitor cells of the first and second heart fields depend on cardiac-specific transcription factors for their differentiation and Wnt/beta-catenin and Bmp act downstream of Notch/RBPJ at this developmental stage.
Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4.
Grinspan et al., Philadelphia, United States. In J Neuropathol Exp Neurol, 2012
The findings of this study suggested that IUGR results in delayed myelination through the generation of oxidative stress that leads to BMP4 upregulation.
An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud.
Maas et al., Boston, United States. In Plos One, 2011
Pitx homeoprotein family members bind a specific site in the Bmp4 incisor epithelium limb bud enhancer element that is necessary for its activity in vivo.
Common TGFβ2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma.
Sowden et al., Glasgow, United Kingdom. In Mol Vis, 2011
No significant associations were identified between FOXC1, TGFbeta2, and BMP4 alleles and haplotypes and primary open-angle glaucoma.
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