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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Bone morphogenetic protein 10

BMP10, bone morphogenetic protein 10
The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BMP-9, ALK-1, SFRP1, V1a, CAN
Papers on BMP10
Comparative transcriptome analysis of atrial septal defect identifies dysregulated genes during heart septum morphogenesis.
New
Jiang et al., Kunming, China. In Gene, Feb 2016
The results indicated that cardiac specific transcriptional factors (GATA4 and NKX2-5), extracellular signal molecules (VEGFA and BMP10) and cardiac sarcomeric proteins (MYL2, MYL3, MYH7, TNNT1 and TNNT3) were downregulated in ASD which may affect heart atrial septum formation, cardiomyocyte proliferation and cardiac muscle development.
The Prodomain-Bound Form of Bone Morphogenetic Protein 10 is Biologically Active on Endothelial Cells.
New
Li et al., Cambridge, United Kingdom. In J Biol Chem, Jan 2016
UNASSIGNED: BMP10 is highly expressed in the developing heart and plays essential roles in cardiogenesis.
BMP10 inhibited the growth and migration of gastric cancer cells.
New
Lu et al., Yancheng, China. In Tumour Biol, Oct 2015
UNASSIGNED: Bone morphogenetic protein 10 (BMP10), a novel member of BMP family, has been identified as an important regulator for angiogenesis.
BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.
New
Bailly et al., Grenoble, France. In Proc Natl Acad Sci U S A, Jul 2015
Two members of the TGFβ family, bone morphogenetic protein 9 (BMP9) and BMP10, have been recently involved in postnatal angiogenesis, both being necessary for remodeling of newly formed microvascular beds.
[PRODUCTION AND CHARACTERIZATION OF THE PANEL OF MONOCLONAL ANTIBODIES AGAINST HUMAN ENDOGLIN].
Klimovich et al., In Tsitologiia, 2014
Endoglin (CD105) is the marker of endothelial and mesenchymal stem cells and the component of TGF-β, BMP-9 and BMP-10-binding receptor complexes.
VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning.
Review
Jakobsson et al., Stockholm, Sweden. In Biochem Soc Trans, 2014
For example, the pro-angiogenic VEGFA is secreted by cells in need of oxygen, presented to the basal side of the endothelium, whereas BMP9 and BMP10 are supplied via the bloodstream in constant interaction with the apical side to suppress angiogenesis.
Investigating the Mechanism of Hyperglycemia-Induced Fetal Cardiac Hypertrophy.
Liu et al., Guangzhou, China. In Plos One, 2014
Meanwhile, the expression of β-MHC and BMP-10 was up-regulated.
Bone morphogenetic protein-10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction.
Li et al., Xi'an, China. In J Cell Biochem, 2014
Bone morphogenetic protein-10 (BMP10) exerts multiple roles in various developmental events; however, the effect of BMP10 and the underlying mechanism involved in cardiac repair remains unclear.
HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region.
Scambler et al., München, Germany. In Circ Res, 2014
Microarray analysis revealed increased expression of Bmp10.
Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia.
Bailly et al., Grenoble, France. In Front Genet, 2013
Among them, BMP9 and BMP10 have been shown to bind directly with high affinity to ALK1 and endoglin, and BMP9 mutations have recently been linked to a vascular anomaly syndrome that has phenotypic overlap with HHT.
Temporal regulation of mRNAs for select bone morphogenetic proteins (BMP), BMP receptors and their associated SMAD proteins during bovine early embryonic development: effects of exogenous BMP2 on embryo developmental progression.
Smith et al., East Lansing, United States. In Reprod Biol Endocrinol, 2013
METHODS: Relative abundance of mRNA for BMP2, BMP3, BMP7, BMP10, SMAD1, SMAD5, ALK3, ALK6, ALK2, BMPR2, ACVR2A and ACVR2B was determined by RT-qPCR analysis of germinal vesicle (GV) and in vitro matured metaphase II (MII) oocytes and in vitro produced embryos collected at pronuclear, 2-cell (C), 4C, 8C, 16C, morula and blastocyst stages.
BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.
GeneRIF
Bailly et al., Grenoble, France. In Blood, 2012
BMP9 and BMP10 are important in postnatal vascular remodeling of the retina and BMP10 can substitute for BMP9.
Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function.
GeneRIF
Shou et al., Indianapolis, United States. In J Biol Chem, 2011
the BMP10-Tbx20 signaling cascade is important for ventricular wall development and maturation.
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.
GeneRIF
Grinberg et al., Cambridge, United States. In J Biol Chem, 2011
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.
GeneRIF
Seidah et al., Montréal, Canada. In J Biol Chem, 2011
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.
ALK1 as an emerging target for antiangiogenic therapy of cancer.
Review
Pietras et al., Stockholm, Sweden. In Blood, 2011
Activation of the endothelial cell-restricted TGF-β type I receptor ALK1 results from the binding of several different ligands of the TGF-β family, including bone morphogenetic protein (BMP) 9, BMP10, and TGF-β.
Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer.
GeneRIF
Jiang et al., Cardiff, United Kingdom. In Cancer Sci, 2010
Bone morphogenetic protein-10 (BMP-10) may function as a tumor suppressor in breast cancer.
Chromatin regulation by Brg1 underlies heart muscle development and disease.
Impact
Chang et al., Stanford, United States. In Nature, 2010
In embryos, Brg1 promotes myocyte proliferation by maintaining Bmp10 and suppressing p57(kip2) expression.
Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands.
Review
Hsueh et al., Stanford, United States. In Hum Reprod Update, 2006
Furthermore, we demonstrated the roles of BMPRII, ALK3 and ALK6 as the receptors for the orphan ligands GDF6, GDF7 and BMP10.
Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.
Impact
Chien et al., San Diego, United States. In Cell, 2004
Transcriptional profiling uncovered the aberrant expression of a unique panel of atrial and conduction system-restricted target genes, as well as the ectopic, high level BMP-10 expression in the adult ventricular myocardium.
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