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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Bone morphogenetic protein 6

BMP-6, bone morphogenetic protein-6
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BMP4, CAN, TGF-beta, HAD, BMP-7
Papers on BMP-6
BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells.
New
Makino et al., Okayama, Japan. In Peptides, Feb 2016
UNASSIGNED: The effects of somatostatin analogs and roles of BMP-6 in the regulation of luteinizing hormone (LH) secretion were investigated using mouse gonadotrope LβT2 cells.
Thymic Carcinoma with Cartilage Formation in a Dog.
New
Uchida et al., Tokyo, Japan. In J Comp Pathol, Feb 2016
In the normal canine thymus, the subcapsular epithelial cells are positive for both CK19 and BMP6.
Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice.
New
Babitt et al., Reggio nell'Emilia, Italy. In Endocrinology, Feb 2016
Bone morphogenetic protein 6 (BMP6) signaling is a central regulator of hepcidin expression in the liver.
BMP-6 inhibits the metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression.
New
Zhang et al., Tangshan, China. In Oncol Rep, Jan 2016
UNASSIGNED: Bone morphogenetic protein-6 (BMP-6) is a multifunctional molecule with distinct abilities in embryogenesis and organogenesis.
Therapeutic potential of regulatory cytokines that target B cells.
Review
New
Yamamoto et al., Tokyo, Japan. In Int Immunol, Jan 2016
In contrast to TGF-β1, which induces extensive fibrosis, TGF-β3 and bone morphogenetic protein 6 (BMP-6)/BMP-7 induce non-scarring wound healing and counteract tissue fibrosis.
BMP6-Engineered MSCs Induce Vertebral Bone Repair in a Pig Model: A Pilot Study.
New
Gazit et al., Los Angeles, United States. In Stem Cells Int, Dec 2015
In this pilot study, allogeneic, porcine mesenchymal stem cells, overexpressing the BMP6 gene (MSC-BMP6), were suspended in fibrin gel and implanted into a vertebral defect to investigate their effect on bone regeneration in a clinically relevant, large animal pig model.
The Function and Regulation of BMP6 in Various Kinds of Stem Cells.
Review
He et al., Shanghai, China. In Curr Pharm Des, 2014
Bone morphogenetic protein 6 (BMP6) belongs to transforming growth factor β(TGF-β) superfamily.
[Growth factors-mediated effects on the differentiation of human adipose-derived stem cells into chondrocytes].
Review
Liu et al., In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2014
It has been reported that bone morphogenetic protein-6 (BMP-6) treatment induced TGF-beta receptor-I expression of hADSCs.
Genome-wide association analysis identifies six new loci associated with forced vital capacity.
Impact
London et al., Rotterdam, Netherlands. In Nat Genet, 2014
We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2.
Bone morphogenetic proteins as regulators of iron metabolism.
Review
Fleming et al., Bethesda, United States. In Annu Rev Nutr, 2013
Specifically, BMP6 serves to relate hepatic iron stores to the hepatocellular expression of the iron-regulatory hormone hepcidin.
Hepcidin antagonists for potential treatments of disorders with hepcidin excess.
Review
Arosio et al., Brescia, Italy. In Front Pharmacol, 2013
In this review we summarized the biochemical interactions of the proteins involved in the BMP/HJV/SMAD pathway and its natural inhibitors, the murine and rat models with high hepcidin levels currently available and finally the progresses in the development of hepcidin antagonists, with particular attention to the role of heparins and heparin sulfate proteoglycans in hepcidin expression and modulation of the BMP6/SMAD pathway.
EndMT contributes to the onset and progression of cerebral cavernous malformations.
Impact
Dejana et al., Milano, Italy. In Nature, 2013
EndMT in CCM1-ablated endothelial cells is mediated by the upregulation of endogenous BMP6 that, in turn, activates the transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signalling pathway.
An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland.
GeneRIF
Makino et al., Okayama, Japan. In J Steroid Biochem Mol Biol, 2012
BMP-6 contributes to the induction of aldosterone production in vivo
Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression.
GeneRIF
Chan et al., Belfast, United Kingdom. In Cancer Sci, 2012
investigated role of BMP6 in esophageal squamous cell carcinoma (SCC) development and progression;high BMP6 activity, defined by strong BMP6 expression with weak noggin or SOST expression, was associated with shorter survival in esophageal SCC patients; results suggest BMP6, noggin and SOST could be used in combination as a prognostic indicator in cancer progression
Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.
GeneRIF
Taketani et al., Tokyo, Japan. In Fertil Steril, 2012
Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.
Promoter methylation of the bone morphogenetic protein 6 gene in multiple myeloma.
GeneRIF
Daibata et al., Kōchi, Japan. In Oncol Rep, 2012
The methylation of BMP6 was correlated with decreased levels of mRNA transcripts.
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.
GeneRIF
Myklebust et al., Oslo, Norway. In Eur J Immunol, 2011
BMP-6 mainly inhibited plasmablast differentiation, and BMP-7 mainly induced apoptosis in human memory B cells
BMP6 orchestrates iron metabolism.
Impact
Camaschella, Milano, Italy. In Nat Genet, 2009
Two new studies now identify BMP6 as the key endogenous regulator of hepcidin.
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.
Impact
Babitt et al., Boston, United States. In Nat Genet, 2009
Here we show that compared with soluble hemojuvelin (HJV.Fc), the homologous DRAGON.Fc is a more potent inhibitor of BMP2 or BMP4 but a less potent inhibitor of BMP6 in vitro.
Lack of the bone morphogenetic protein BMP6 induces massive iron overload.
Impact
GeneRIF
Roth et al., Toulouse, France. In Nat Genet, 2009
Mice deficient in Bmp6 develop classical hemochromatosis.
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