The EMT signaling pathways in endometrial carcinoma.
Barcelona, Spain. In Clin Transl Oncol, Oct 2012
The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation.
RAC1 activation mediates Twist1-induced cancer cell migration.
Taipei, Taiwan. In Nat Cell Biol, Apr 2012
Twist1 cooperates with BMI1 to suppress let-7i expression, which results in upregulation of NEDD9 and DOCK3, leading to RAC1 activation and enabling mesenchymal-mode movement in three-dimensional environments.