GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
BMI1 polycomb ring finger oncogene
Bmi-1
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Papers using
Bmi-1
antibodies
The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells
Supplier
In The Journal of Cell Biology, 2004
... Control and one of two different BMI1 shRNA plasmids were obtained from OriGene.
Papers on
Bmi-1
Apoptosis differently affects lineage tracing of lgr5 and bmi1 intestinal stem cell populations.
New
Impact
Singapore, Singapore. In Cell Stem Cell, 07 Apr 2013
We found that about 40% of apoptotic cells were Lgr5-positive whereas Bmi1-positive ISCs became sensitive to tamoxifen upon entering a proliferative state.
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.
New
Hiroshima, Japan. In Blood, 07 Apr 2013
Key points BMI1 overexpression is one of the second hit partner genes of RUNX1 mutations that contribute to the development of MDS.
Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis.
New
In J Clin Invest, 01 Apr 2013
Subsequent experiments demonstrated that miR-487b directly targeted SUZ12, BMI1, WNT5A, MYC, and KRAS.
Establishment and characterization of a telomerase immortalized human gingival epithelial cell line.
New
Louisville, United States. In J Periodontal Res, 27 Mar 2013
MATERIAL AND METHODS: Human primary GECs were immortalized with a bmi1/hTERT combination to prevent cell cycle triggers of senescence and telomere shortening.
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.
New
Worcester, United States. In Embo Mol Med, 21 Mar 2013
GLI1 also induces BMI-1, a key stem cell factor, and it enhances NRP2 expression and the function of α6β1, establishing an autocrine loop.
Differentiation of human embryonic stem cells into cells with corneal keratocyte phenotype.
New
Pittsburgh, United States. In Plos One, Dec 2012
After expansion as a monolayer, mRNAs typifying adult stromal stem cells were detected, including BMI1, KIT, NES, NOTCH1, and SIX2.
CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.
New
Impact
Boston, United States. In Nat Genet, Nov 2012
Morpholino-based knockdown of zebrafish chmp1a resulted in brain defects resembling those seen after bmi1a and bmi1b knockdown, which were partially rescued by INK4A ortholog knockdown, further supporting links between CHMP1A and BMI1-mediated regulation of INK4A.
The EMT signaling pathways in endometrial carcinoma.
Review
New
Barcelona, Spain. In Clin Transl Oncol, Oct 2012
The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation.
RAC1 activation mediates Twist1-induced cancer cell migration.
New
Impact
Taipei, Taiwan. In Nat Cell Biol, Apr 2012
Twist1 cooperates with BMI1 to suppress let-7i expression, which results in upregulation of NEDD9 and DOCK3, leading to RAC1 activation and enabling mesenchymal-mode movement in three-dimensional environments.
Role of stemness-related molecules in neuroblastoma.
Review
New
Chiba, Japan. In Pediatr Res, Apr 2012
Recently, our group reported that a CSC marker for several malignancies, CD133, and the stemness-related polycomb BMI1 have functions to repress NB cell differentiation.
Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences.
Review
New
Austin, United States. In Stem Cells, Mar 2012
Emerging evidences show that the chemoresistance of CSCs are in part due to the activation of B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), a stem cell factor, and a polycomb group family member.
Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection.
GeneRIF
Taipei, Taiwan. In Biosci Rep, 2011
Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection
Epigenetic and epigenomic mechanisms shape sarcoma and other mesenchymal tumor pathogenesis.
Review
Vienna, Austria. In Epigenomics, 2011
The epigenetic activities of histone-modifying and chromatin-remodeling enzymes such as SUV39H1/KMT1A, EZH2/KMT6A and BMI1 are central to epigenetic-regulated transformation, a property we coin oncoepigenic.
Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes.
GeneRIF
Belfast, United Kingdom. In J Virol, 2011
Correlating with the loss of H3K27me3, human papillomavirus 16 E6/E7-expressing cells exhibited derepression of specific EZH2-, KMD6A-, and BMI1-targeted HOX genes.
Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.
GeneRIF
New York City, United States. In Mol Cell Biol, 2011
Our results establish a connection between Sox2 and BMI-1 in maintaining self-renewal and identify BMI-1 as a key mediator of Sox2 function.
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.
Impact
GeneRIF
San Francisco, United States. In Nature, 2011
Bmi1-expressing stem cells may represent both a reserve stem cell pool in case of injury to the small intestine epithelium and a source for replenishment of the Lgr5-expressing cells under non-pathological conditions
BMI1 as a novel target for drug discovery in cancer.
Review
South Plainfield, United States. In J Cell Biochem, 2011
Bmi-1 plays a critical role in the self-renewal of adult stem cells.
Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci.
Impact
GeneRIF
Boston, United States. In Cell Stem Cell, 2011
controls lung stem cell self-renewal
Coordinated regulation of polycomb group complexes through microRNAs in cancer.
Impact
Ann Arbor, United States. In Cancer Cell, 2011
These miRNAs, in turn, regulate the expression of PRC1 proteins BMI1 and RING2.
