FAL1ing inside an amplicon.
Pamplona, Spain. In Cancer Cell, 08 Oct 2014
FAL1 acts as an oncogene by stabilizing BMI1, which results in the repression of CDKN1A expression.
The role of BMI1 as a biomarker of cancer stem cells in head and neck cancer: a review.
Catanzaro, Italy. In Oncology, Dec 2013
Emerging studies show that BMI1 (B cell-specific Moloney murine leukemia virus integration site 1) has an important function as a biomarker of cancer stem cells (CSCs), i.e. cells with self-renewal characteristics, capable of tumor initiation, progression, invasion, metastasis, tumor recurrence and resistance to chemotherapy and radiotherapy.
What is the clinical value of cancer stem cell markers in gliomas?
Odense, Denmark. In Int J Clin Exp Pathol, 2012
Using the Pubmed database, twenty-seven CSC studies looking at membrane markers (CD133, podoplanin, CD15, and A2B5), filament markers (nestin), RNA-binding proteins (Musashi-1) and transcription factors (BMI1, SOX2, Id1 and Oct-4) qualified for this review.