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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Apr 2015.

BMI1 polycomb ring finger oncogene

Bmi-1
Top mentioned proteins: Polycomb, CAN, p16, EZH2, Histone
Papers using Bmi-1 antibodies
The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells
Supplier
Hendzel Michael J. et al., In The Journal of Cell Biology, 2004
... Control and one of two different BMI1 shRNA plasmids were obtained from OriGene.
Papers on Bmi-1
The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions.
New
Sardet et al., Montpellier, France. In Cell Rep, 02 May 2015
UNASSIGNED: Recent data support the notion that a group of key transcriptional regulators involved in tumorigenesis, including MYC, p53, E2F1, and BMI1, share an intriguing capacity to simultaneously regulate metabolism and cell cycle.
E4F1 Is a Master Regulator of CHK1-Mediated Functions.
New
Sauvageau et al., Montréal, Canada. In Cell Rep, 01 May 2015
UNASSIGNED: It has been previously shown that the polycomb protein BMI1 and E4F1 interact physically and genetically in the hematopoietic system.
Anticancer Effect of AntiMalarial Artemisinin Compounds.
New
Das, Dibrugarh, India. In Ann Med Health Sci Res, 31 Mar 2015
Artemisinins seem to regulate key factors such as nuclear factor-kappa B, survivin, NOXA, hypoxia-inducible factor-1α, and BMI-1, involving multiple pathways that may affect drug response, drug interactions, drug resistance, and associated parameters upon normal cells.
Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer.
Review
New
Troelsen et al., Denmark. In Clin Colorectal Cancer, Jan 2015
This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell-specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC.
Silencing of bmi-1 gene enhances chemotherapy sensitivity in human glioblastoma cells.
New
Liu et al., Shenyang, China. In Med Sci Monit, Dec 2014
BACKGROUND The aim of this study was to determine the influence of the BMI1 gene on chemotherapy sensitivity in human glioma cells.
MK3 Modulation Affects BMI1-Dependent and Independent Cell Cycle Check-Points.
New
Voncken et al., Maastricht, Netherlands. In Plos One, Dec 2014
In agreement with this, the PRC1 oncoprotein BMI1, but not the PCR2 protein EZH2, bypasses MK3-induced senescence in fibroblasts and suppresses P16INK4A expression.
A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer.
New
Impact
Zhang et al., Philadelphia, United States. In Cancer Cell, Oct 2014
FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A.
FAL1ing inside an amplicon.
New
Impact
Huarte et al., Pamplona, Spain. In Cancer Cell, Oct 2014
FAL1 acts as an oncogene by stabilizing BMI1, which results in the repression of CDKN1A expression.
Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
New
Impact
Eto et al., Kyoto, Japan. In Cell Stem Cell, May 2014
This approach involves the establishment of stable immortalized megakaryocyte progenitor cell lines (imMKCLs) from PSC-derived hematopoietic progenitors through the overexpression of BMI1 and BCL-XL to respectively suppress senescence and apoptosis and the constrained overexpression of c-MYC to promote proliferation.
Self-renewal as a therapeutic target in human colorectal cancer.
Impact
O'Brien et al., Toronto, Canada. In Nat Med, 2014
Here we demonstrate that tumor formation and, more specifically, human colorectal CIC function are dependent on the canonical self-renewal regulator BMI-1.
Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.
Review
Blanco-Aparicio et al., Madrid, Spain. In Front Oncol, 2013
The use of retroviral insertional mutagenesis and refined approaches such as complementation tagging has allowed the identification of myc, pim, and a third group of genes (including bmi1 and gfi1) as complementing genes in lymphomagenesis.
The role of BMI1 as a biomarker of cancer stem cells in head and neck cancer: a review.
Review
Puzzo et al., Catanzaro, Italy. In Oncology, 2013
Emerging studies show that BMI1 (B cell-specific Moloney murine leukemia virus integration site 1) has an important function as a biomarker of cancer stem cells (CSCs), i.e. cells with self-renewal characteristics, capable of tumor initiation, progression, invasion, metastasis, tumor recurrence and resistance to chemotherapy and radiotherapy.
A family of pleiotropically acting microRNAs in cancer progression, miR-200: potential cancer therapeutic targets.
Review
Li et al., Shantou, China. In Curr Pharm Des, 2013
Importantly, miR-200s also modulate the self-renewal ability of cancer stem cells by targeting BMI1 and SUZ12.
Histone modifications, stem cells and prostate cancer.
Review
Helgason et al., Vancouver, Canada. In Curr Pharm Des, 2013
Recently, the catalytic component of PRC1 (BMI1) was shown to play critical roles in prostate CRC self-renewal and resistance to chemotherapy, resulting in poorer prognosis.
Unraveling tumor suppressor networks with in vivo RNAi.
Impact
Hemann et al., Cambridge, United States. In Cell Stem Cell, 2013
BMI1 is a known oncogenic transcriptional repressor in glioblastoma stem-like cells, but its downstream mediators are poorly understood.
Bmi1 is required for regeneration of the exocrine pancreas in mice.
GeneRIF
Hebrok et al., San Francisco, United States. In Gastroenterology, 2012
Bmi1 contributes to regeneration of the exocrine pancreas after cerulein-induced injury through cell autonomous mechanisms, in part by regulating Cdkn2a expression, and non-cell autonomous mechanisms.
Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma.
GeneRIF
Larocca et al., Roma, Italy. In Am J Clin Pathol, 2012
We found that overexpression of c-Myc was significantly associated with that of BMI1, and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival.
Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
GeneRIF
Azuara et al., London, United Kingdom. In Genes Dev, 2012
Bmi1 overlaps with the nascent Gata6 and Nanog protein from the eight-cell stage onward before it preferentially cosegregates with Gata6 in primitive endoderm progenitors
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
GeneRIF
Iwama et al., Chiba, Japan. In Plos One, 2011
overexpression of Bmi1 confers resistance to stresses, particularly oxidative stress, onto hematopoietic stem cells. This enhances their regenerative capacity and suggests that Bmi1 is located downstream of ROS signaling and negatively regulated by it.
Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity.
GeneRIF
Jin et al., Harbin, China. In Br J Biomed Sci, 2011
Bmi-1 siRNA has a role in inhibiting ovarian cancer cell line growth and decreasing telomerase activity
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