The evolutionary landscape of PRC1 core components in green lineage.
Changsha, China. In Planta, 04 Feb 2016
We evaluated the origin of plant PRC1 RING-finger proteins (RING1 and BMI1) through comparing with the homologs in some representative unikonts and using BMI1- and RING1-like proteins as reciprocal outgroup, finding both PRC1 RING-finger proteins have the earliest origin in mosses, similar to LHP1.
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.
San Diego, United States. In Nature, Jun 2015
Our previous studies revealed that B cells recruited by the chemokine CXCL13 into prostate cancer tumours promote the progression of castrate-resistant prostate cancer by producing lymphotoxin, which activates an IκB kinase α (IKKα)-BMI1 module in prostate cancer stem cells.
MicroRNA Regulation of Human Breast Cancer Stem Cells.
Kōbe, Japan. In J Clin Med, 2014
The miRNAs and their clusters, such as the miR-200 clusters, miR-183 cluster, miR-221-222 cluster, let-7, miR-142 and miR-214, target the genes and pathways important for stem cell maintenance, such as the self-renewal gene BMI1, apoptosis, Wnt signaling, Notch signaling, and epithelial-to-mesenchymal transition.
FAL1ing inside an amplicon.
Pamplona, Spain. In Cancer Cell, 2014
FAL1 acts as an oncogene by stabilizing BMI1, which results in the repression of CDKN1A expression.