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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

BMI1 polycomb ring finger oncogene

Bmi-1
Top mentioned proteins: Polycomb, CAN, p16, EZH2, c-Myc
Papers using Bmi-1 antibodies
The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells
Supplier
Hendzel Michael J. et al., In The Journal of Cell Biology, 2004
... Control and one of two different BMI1 shRNA plasmids were obtained from OriGene.
Papers on Bmi-1
CD44 affects the expression level of FOS‑like antigen 1 in cervical cancer tissues.
New
Xue et al., Changsha, China. In Mol Med Report, 31 May 2014
However, BMI1 polycomb ring finger oncogene, ck5, tumor protein p53 and lactotransferrin genes exhibited low expression levels in CD44+ cells.
Disruption of Polycomb Repressor Complex-Mediated Gene Silencing Reactivates HIV-1 Provirus in Latently Infected Cells.
New
Choi et al., South Korea. In Intervirology, 14 Apr 2014
Results: PRC proteins (EED, BMI-1, and RNF2) were dramatically downregulated in latent cells after PMA treatment.
Recruitment of HP1β to UVA-Induced DNA Lesions is Independent of Radiation-Induced Changes in A-Type Lamins.
New
Bártová et al., Brno, Czech Republic. In Biol Cell, 10 Apr 2014
We asked whether the recruitment of HP1β, 53BP1, and BMI1 proteins to ultraviolet (UVA)-induced DNA lesions requires functional A-type lamins.
Comparison of Markers and Functional Attributes of Human Adipose-Derived Stem Cells and Dedifferentiated Adipocyte Cells from Subcutaneous Fat of an Obese Diabetic Donor.
New
Cooper et al., Tampa, United States. In Adv Wound Care (new Rochelle), 01 Apr 2014
They also expressed similar levels of Oct4, BMI1, KLF4, and SALL4.
Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling.
New
Miller et al., Toronto, Canada. In Plos Genet, 31 Mar 2014
In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively.
Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells.
New
Impact
Eto et al., Kyoto, Japan. In Cell Stem Cell, 12 Mar 2014
This approach involves the establishment of stable immortalized megakaryocyte progenitor cell lines (imMKCLs) from PSC-derived hematopoietic progenitors through the overexpression of BMI1 and BCL-XL to respectively suppress senescence and apoptosis and the constrained overexpression of c-MYC to promote proliferation.
Self-renewal as a therapeutic target in human colorectal cancer.
New
Impact
O'Brien et al., Toronto, Canada. In Nat Med, Jan 2014
Here we demonstrate that tumor formation and, more specifically, human colorectal CIC function are dependent on the canonical self-renewal regulator BMI-1.
Relevance of cancer initiating/stem cells in carcinogenesis and therapy resistance in oral cancer.
Review
New
Bhutia et al., India. In Oral Oncol, Sep 2013
Oral CSCs populations show upregulation of the stem cell related genes Oct-4, Nanog, Nestin, CK19, BMI-1, CD117 (c-kit), CD44 and CD133 with sunken expression of involucrin and CK13.
BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.
New
Impact
Klein et al., San Francisco, United States. In Nat Cell Biol, Jul 2013
The polycomb group gene Bmi1 is required for maintenance of adult stem cells in many organs.
Unraveling tumor suppressor networks with in vivo RNAi.
New
Impact
Hemann et al., Cambridge, United States. In Cell Stem Cell, Jul 2013
BMI1 is a known oncogenic transcriptional repressor in glioblastoma stem-like cells, but its downstream mediators are poorly understood.
In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.
New
Impact
van Lohuizen et al., Amsterdam, Netherlands. In Cancer Cell, Jun 2013
In mouse and human neural progenitor and glioblastoma "stem-like" cells, we identified key targets of the Polycomb-group protein BMI1 by combining ChIP-seq with in vivo RNAi screening.
What is the clinical value of cancer stem cell markers in gliomas?
Review
Kristensen et al., Odense, Denmark. In Int J Clin Exp Pathol, 2012
Using the Pubmed database, twenty-seven CSC studies looking at membrane markers (CD133, podoplanin, CD15, and A2B5), filament markers (nestin), RNA-binding proteins (Musashi-1) and transcription factors (BMI1, SOX2, Id1 and Oct-4) qualified for this review.
Mechanism and method for generating tumor-free iPS cells using intronic microRNA miR-302 induction.
Review
Ying et al., Santa Fe Springs, United States. In Methods Mol Biol, 2012
Additionally, miR-302 also silenced BMI-1, a cancer stem cell marker gene, to promote the expression of two senescence-associated tumor suppressor genes, p16Ink4a and p14/p19Arf.
The EMT signaling pathways in endometrial carcinoma.
Review
Reventos et al., Barcelona, Spain. In Clin Transl Oncol, 2012
The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation.
Bmi1 is required for regeneration of the exocrine pancreas in mice.
GeneRIF
Hebrok et al., San Francisco, United States. In Gastroenterology, 2012
Bmi1 contributes to regeneration of the exocrine pancreas after cerulein-induced injury through cell autonomous mechanisms, in part by regulating Cdkn2a expression, and non-cell autonomous mechanisms.
Prognostic relevance of c-Myc and BMI1 expression in patients with glioblastoma.
GeneRIF
Larocca et al., Roma, Italy. In Am J Clin Pathol, 2012
We found that overexpression of c-Myc was significantly associated with that of BMI1, and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival.
Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
GeneRIF
Azuara et al., London, United Kingdom. In Genes Dev, 2012
Bmi1 overlaps with the nascent Gata6 and Nanog protein from the eight-cell stage onward before it preferentially cosegregates with Gata6 in primitive endoderm progenitors
Role of stemness-related molecules in neuroblastoma.
Review
Kamijo, Chiba, Japan. In Pediatr Res, 2012
Recently, our group reported that a CSC marker for several malignancies, CD133, and the stemness-related polycomb BMI1 have functions to repress NB cell differentiation.
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
GeneRIF
Iwama et al., Chiba, Japan. In Plos One, 2011
overexpression of Bmi1 confers resistance to stresses, particularly oxidative stress, onto hematopoietic stem cells. This enhances their regenerative capacity and suggests that Bmi1 is located downstream of ROS signaling and negatively regulated by it.
Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity.
GeneRIF
Jin et al., Harbin, China. In Br J Biomed Sci, 2011
Bmi-1 siRNA has a role in inhibiting ovarian cancer cell line growth and decreasing telomerase activity
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