The evolutionary landscape of PRC1 core components in green lineage.
Changsha, China. In Planta, Feb 2016
We evaluated the origin of plant PRC1 RING-finger proteins (RING1 and BMI1) through comparing with the homologs in some representative unikonts and using BMI1- and RING1-like proteins as reciprocal outgroup, finding both PRC1 RING-finger proteins have the earliest origin in mosses, similar to LHP1.
Cancer stem cells in human digestive tract malignancies.
Mashhad, Iran. In Tumour Biol, Nov 2015
For instance, identification of markers associated with digestive tract CSCs, such as CD44, CD133, CD24, EpCAM, LGR5, ALDH1, and BMI1, has made it possible to develop more accurate diagnosis approaches.
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectives.
Gold Coast, Australia. In Crit Rev Oncol Hematol, Oct 2015
It has also been demonstrated that stem cell markers like ALDH1, HIWI, Oct3/4, ABCG2, SOX2, SALL4, BMI-1, NANOG, CD133 and podoplanin are associated with patient's prognosis, pathological stages, cancer recurrence and therapy resistance.
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.
San Diego, United States. In Nature, Jun 2015
Our previous studies revealed that B cells recruited by the chemokine CXCL13 into prostate cancer tumours promote the progression of castrate-resistant prostate cancer by producing lymphotoxin, which activates an IκB kinase α (IKKα)-BMI1 module in prostate cancer stem cells.
MicroRNA Regulation of Human Breast Cancer Stem Cells.
Kōbe, Japan. In J Clin Med, 2014
The miRNAs and their clusters, such as the miR-200 clusters, miR-183 cluster, miR-221-222 cluster, let-7, miR-142 and miR-214, target the genes and pathways important for stem cell maintenance, such as the self-renewal gene BMI1, apoptosis, Wnt signaling, Notch signaling, and epithelial-to-mesenchymal transition.
FAL1ing inside an amplicon.
Pamplona, Spain. In Cancer Cell, 2014
FAL1 acts as an oncogene by stabilizing BMI1, which results in the repression of CDKN1A expression.