eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
Villejuif, France. In Nature, 2014
Resistance to treatment and maintenance of eIF4F complex formation is associated with one of three mechanisms: reactivation of MAPK signalling, persistent ERK-independent phosphorylation of the inhibitory eIF4E-binding protein 4EBP1 or increased pro-apoptotic BCL-2-modifying factor (BMF)-dependent degradation of eIF4G.
Why does the bone marrow fail in Fanconi anemia?
Cambridge, United Kingdom. In Blood, 2014
The inherited bone marrow failure (BMF) syndromes are a rare and diverse group of genetic disorders that ultimately result in the loss of blood production.