gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Prune homolog 2

BMCC1, PRUNE2, BNIPXL, KIAA0367, BCH motif-containing molecule at the carboxyl terminal region 1
Top mentioned proteins: Prune, RhoGAP, CAN, bcl-2, V1a
Papers on BMCC1
The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.
Chinnaiyan et al., Tiruchchirāppalli, India. In Cancer Res, Oct 2015
In addition to previously identified mutations in TP53, RB1, and PIK3CA, we discovered activating mutations of oncogenes, including HRAS and loss-of-function mutations in PRUNE2 and NOTCH family genes in MCPyV-negative MCC.
PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.
Arap et al., São Paulo, Brazil. In Proc Natl Acad Sci U S A, Aug 2015
Here we identify PRUNE2, a target protein-coding gene variant, which harbors the PCA3 locus, thereby classifying PCA3 as an antisense intronic long noncoding (lnc)RNA.
Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.
Morreau et al., Singapore, Singapore. In J Clin Endocrinol Metab, Feb 2015
Furthermore, recurrent germ line and somatic mutations in prune homolog 2 [Drosophila] (PRUNE2) were found in PC and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found.
Identification and diagnostic performance of a small RNA within the PCA3 and BMCC1 gene locus that potentially targets mRNA.
Catto et al., Sheffield, United Kingdom. In Cancer Epidemiol Biomarkers Prev, 2015
METHODS: We computed feasible RNA hairpins within the BMCC1 gene (encompassing PCA3) and searched a prostate transcriptome for these.
BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis.
Nakagawara et al., Chiba, Japan. In Cell Death Dis, 2014
BNIP2 and Cdc42GAP homology (BCH) motif-containing molecule at the carboxyl-terminal region 1 (BMCC1) gene is highly expressed in patients with favorable neuroblastoma (NB).
Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.
Polzer et al., München, Germany. In Plos One, 2013
Gene expression analysis revealed distinct difference between FLT3-ITD and FLT3-TKD for STAT5 target gene expression as well as deregulation of SOCS2, ENPP2, PRUNE2 and ART3.
The prognostic role of PRUNE2 in leiomyosarcoma.
Yang et al., Tianjin, China. In Ai Zheng, 2013
PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma.
Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.
Nakagawa et al., Gifu, Japan. In Brain Res, 2013
Prune homolog 2 (Drosophila) (PRUNE2) encodes a BCH motif-containing protein that shares homology with the Cayman ataxia-related protein Caytaxin.
Identification of novel tissue-specific genes by analysis of microarray databases: a human and mouse model.
Lee et al., Columbus, United States. In Plos One, 2012
Three novel tissue-specific genes were discovered by this approach including AMDHD1 (amidohydrolase domain containing 1) in the liver, PRUNE2 (prune homolog 2) in the heart, and ACVR1C (activin A receptor, type IC) in adipose tissue.
BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells.
Lavin et al., Brisbane, Australia. In Plos One, 2012
BMCC1 was initially annotated as two genes (C9orf65/PRUNE and BNIPXL) on either side of PCA3 but our data suggest that it represents a single gene coding for a high molecular weight protein.
Novel pathways in the pathobiology of human abdominal aortic aneurysms.
Kuivaniemi et al., Dresden, Germany. In Pathobiology, 2012
Novel validated genes in AAA pathobiology included ADCY7, ARL4C, BLNK, FOSB, GATM, LYZ, MFGE8, PRUNE2, PTPRC, SMTN, TMODI and TPM2.
[Expression of PRUNE2 mRNA and its positive correlation with non-coding RNA PCA3 in leiomyosarcoma].
Zhang et al., Tianjin, China. In Zhonghua Zhong Liu Za Zhi, 2012
Non-coding RNA PCA3 locates in the intron of PRUNE2 and may play a role in PRUNE2 expression.
The expression and localization of Prune2 mRNA in the central nervous system.
Nakagawa et al., Gifu, Japan. In Neurosci Lett, 2011
Prune homolog 2 (Drosophila) (PRUNE2) and its isoforms -C9orf65, BCH motif-containing molecule at the carboxyl terminal region 1 (BMCC1), and BNIP2 Extra Long (BNIPXL) - have been shown to be a susceptibility gene for Alzheimer's disease, a biomarker for leiomyosarcomas, a proapoptotic protein in neuronal cells, and an antagonist of cellular transformation, respectively.
Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues.
Nakabeppu et al., Fukuoka, Japan. In J Mol Neurosci, 2011
The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems.
Cell cloning-based transcriptome analysis in Rett patients: relevance to the pathogenesis of Rett syndrome of new human MeCP2 target genes.
Bienvenu et al., Paris, France. In J Cell Mol Med, 2010
Most importantly, the finding that at least two of these genes (BMCC1 and RNF182) were shown to be involved in cell survival and/or apoptosis may suggest that impaired MeCP2 function could alter the survival of neurons thus compromising brain function without inducing cell death.
Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer.
Schalken et al., Nijmegen, Netherlands. In Prostate, 2010
The androgen regulation of PRUNE2 expression in prostate cancer cells was found to not be of any diagnostic value.
New genomic structure for prostate cancer specific gene PCA3 within BMCC1: implications for prostate cancer detection and progression.
Gardiner et al., Kogarah, Australia. In Plos One, 2008
the longer BMCC1-1 isoform is upregulated in PCa tissues and metastases
BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain.
Low et al., Singapore, Singapore. In J Cell Sci, 2008
findings show the BNIP2 & BCH domain of BNIPXL interacts with specific conformers of RhoA & mediates association with catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide exchange factor; BNIPXL inhibits Lbc-induced oncogenic transformation
Cleavage of BNIP-2 and BNIP-XL by caspases.
Liu et al., Chapel Hill, United States. In Biochem Biophys Res Commun, 2008
Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities.
share on facebooktweetadd +1mail to friends