Novel pathways in the pathobiology of human abdominal aortic aneurysms.
Dresden, Germany. In Pathobiology, 2012
Novel validated genes in AAA pathobiology included ADCY7, ARL4C, BLNK, FOSB, GATM, LYZ, MFGE8, PRUNE2, PTPRC, SMTN, TMODI and TPM2.
The expression and localization of Prune2 mRNA in the central nervous system.
Gifu, Japan. In Neurosci Lett, 2011
Prune homolog 2 (Drosophila) (PRUNE2) and its isoforms -C9orf65, BCH motif-containing molecule at the carboxyl terminal region 1 (BMCC1), and BNIP2 Extra Long (BNIPXL) - have been shown to be a susceptibility gene for Alzheimer's disease, a biomarker for leiomyosarcomas, a proapoptotic protein in neuronal cells, and an antagonist of cellular transformation, respectively.
Cleavage of BNIP-2 and BNIP-XL by caspases.
Chapel Hill, United States. In Biochem Biophys Res Commun, 2008
Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities.