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Aryl hydrocarbon receptor nuclear translocator-like 2

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CLOCK, Tic, CRY1, period 2, NPAS2
Papers on BMAL2
Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients.
Yamagata et al., Tochigi, Japan. In Brain Dev, Jan 2016
Six missense changes were detected only in individuals with ASD with sleep disturbance: p.F498S in TIMELESS, p.S20R in NR1D1, p.R493C in PER3, p.H542R in CLOCK, p.L473S in ARNTL2, and p.A325V in MTNR1B.
Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content.
Staiger et al., Tübingen, Germany. In Plos One, Dec 2015
To this end, genotype-phenotype associations of 121 common single nucleotide polymorphisms (SNPs) tagging ARNTL, ARNTL2, CLOCK, CRY1, CRY2, PER1, PER2, PER3, and TIMELESS were assessed in a study population of 1,715 non-diabetic individuals metabolically phenotyped by 5-point oral glucose tolerance tests.
High-throughput alternative splicing detection using dually constrained correspondence analysis (DCCA).
Brutsche et al., Sankt Gallen, Switzerland. In J Biomed Inform, Dec 2015
Splicing candidates reveal a series of genes related to carcinogenesis (SFTPB), cell adhesion (STAB2, PCDH15, HABP2), tumor aggressiveness (ARNTL2), apoptosis, proliferation and differentiation (PDE4D, FLT3, IL1R2), cell invasion (ETV1), as well as tumor growth (OLFM4, FGF14), tumor necrosis (AFF3) or tumor suppression (TUSC3, CSMD1, RHOBTB2, SERPINB5), with indication of known alternative splicing in a majority of genes.
Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.
Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group et al., Tokushima, Japan. In Diabetes Res Clin Pract, Dec 2015
AIMS: Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis.
The soluble macrophage activation markers sCD163 and Mannose Receptor (sMR) predict mortality in patients with liver cirrhosis without or with acute-on-chronic liver failure (ACLF).
CANONIC study investigators of the EASL-CLIF Consortium. et al., Århus, Denmark. In J Hepatol, Dec 2015
The patients' clinical course was registered and their MELD, CLIF-C Acute Decompensation (AD), and CLIF-C ACLF-scores computed at inclusion.
Circadian rhythm-related genes: implication in autoimmunity and type 1 diabetes.
Rogner et al., Paris, France. In Diabetes Obes Metab, Sep 2015
Recent findings in the non-obese diabetic mouse model pinpoint to specific mechanisms controlling type 1 diabetes by the clock-related gene Arntl2 in the immune system.
Systematic analysis of circadian genes using genome-wide cDNA microarrays in the inflammatory bowel disease transcriptome.
Latiano et al., In Chronobiol Int, Aug 2015
Among the core clock genes ARNTL2 and RORA were up-regulated, while CSNK2B, NPAS2, PER1 and PER3 were down-regulated in CD specimens.
Submassive hepatic necrosis distinguishes HBV-associated acute on chronic liver failure from cirrhotic patients with acute decompensation.
Weng et al., Shanghai, China. In J Hepatol, Jul 2015
Patients with SMHN presented with more severely impaired hepatic function, a higher prevalence of multiple organ failure (as indicated by higher CLIF-SOFA and SOFA scores) and a shorter interval between acute decompensation and liver transplantation than those without SMHN (p<0.01 for all parameters).
Clock genes in human alcohol abuse and comorbid conditions.
Partonen, Helsinki, Finland. In Alcohol, Jun 2015
Concerning alcohol use, the current findings give support, but are preliminary to, the associations of ARNTL (BMAL1) rs6486120 with alcohol consumption, ARNTL2 rs7958822 and ARNTL2 rs4964057 with alcohol abuse, and PER1 rs3027172 and PER2 rs56013859 with alcohol dependence.
Ube3a imprinting impairs circadian robustness in Angelman syndrome models.
Johnson et al., Nashville, United States. In Curr Biol, Apr 2015
The ubiquitin ligase encoded by Ube3a interacts with the central clock components BMAL1 and BMAL2.
Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis.
Mandelin et al., Helsinki, Finland. In Plos One, 2014
OBJECTIVE: Patients with rheumatoid arthritis (RA) have altered circadian rhythm of circulating serum cortisol, melatonin and IL-6, as well as disturbance in the expression of clock genes ARNTL2 and NPAS2.
Genetic association study of circadian genes with seasonal pattern in bipolar disorders.
Etain et al., Paris, France. In Sci Rep, 2014
A SP in BD was nominally associated with 14 SNPs identified in 6 circadian genes: NPAS2, CRY2, ARNTL, ARNTL2, RORA and RORB.
Clock gene variants in mood and anxiety disorders.
Partonen, Helsinki, Finland. In J Neural Transm, 2012
Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).
ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer.
Piepoli et al., San Giovanni Rotondo, Italy. In J Cancer Res Clin Oncol, 2012
ARNTL2 expression is increased in colorectal cancer and in a highly proliferative colon cancer cell line and is related to tumor invasiveness and aggressiveness.
Decreased expression of Bmal2 in patients with Parkinson's disease.
Cai et al., Beijing, China. In Neurosci Lett, 2011
results show a difference in the expression pattern of Bmal2, but not Clock and Dec1 in PD.
[Molecular mechanisms of circadian clock functioning].
Minchenko et al., In Ukr Biokhim Zh (1999), 2011
Factors of groups Period (PER1, PER2 and PER3), BMAL (BMAL1 and BMAL2), CRYptochromes (CRY1 and CRY2) as well as some other factors are the components of this circadian CLOCK system.
Downregulation of the circadian rhythm related gene Arntl2 suppresses diabetes protection in Idd6 NOD.C3H congenic mice.
Rogner et al., Paris, France. In Clin Exp Pharmacol Physiol, 2010
Results provide additional support for the protective role of the Arntl2 gene located in locus Idd6 in diabetes progression in NOD.C3H congenic mice.
Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.
Johnson et al., Nashville, United States. In Curr Biol, 2010
Expression of Bmal2 can rescue the clock and metabolic phenotypes of Bmal1-knockout mice, including rhythmic locomotor activity, rhythmic metabolism, low body weight, and enhanced fat deposition.
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription.
Fukada et al., Tokyo, Japan. In J Biol Chem, 2009
PER2 is inhibited by BMAL2-CLOCK, which reemphasizes its negative role and a positive role of BMAL2 in circadian transcription
Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders.
Oishi, Tsukuba, Japan. In Clin Exp Hypertens, 2009
The circadian expression of PAI-1 gene is thought to be directly regulated by the circadian clock proteins such as CLOCK and BMAL1/BMAL2 which drive the endogenous biological clock.
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