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proteins. Page last changed on 08 Dec 2016.
PR domain containing 1, with ZNF domain
Blimp-1, PRDM1, PRDI-BF1
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008] (from
Robertson et al., Oxford, United Kingdom. In Genes Dev, 2012
the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of endovascular trophoblast giant cells and defines a lineage-restricted progenitor cell population contributing to placental growth and morphogenesis