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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

PR domain containing 1, with ZNF domain

Blimp-1, PRDM1, PRDI-BF1
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using Blimp-1 antibodies
Papers on Blimp-1
Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.
GeneRIF
Robertson et al., Oxford, United Kingdom. In Genes Dev, 2012
the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of endovascular trophoblast giant cells and defines a lineage-restricted progenitor cell population contributing to placental growth and morphogenesis
Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.
GeneRIF
Bikoff et al., Oxford, United Kingdom. In Mol Cell Biol, 2012
Alternative splicing regulates Blimp-1 recruitment of corepressors and DNA binding activity.
Conditional inactivation of Blimp1 in adult mice promotes increased bone mass.
GeneRIF
Miyamoto et al., Tokyo, Japan. In J Biol Chem, 2012
Conditional inactivation of Blimp1 inhibited osteoclast formation and increased bone mass in both male and female adult mice.
Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.
GeneRIF
Fearon et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2012
The CTLA-4/Hippo pathway/Blimp-1 system may couple terminal differentiation of CD8(+) T cell with the magnitude of clonal expansion.
The germ cell determinant Blimp1 is not required for derivation of pluripotent stem cells.
Impact
GeneRIF
Surani et al., Cambridge, United Kingdom. In Cell Stem Cell, 2012
Although Blimp1 is obligatory for primordial germ cell specification, it is not required for the reversion of epiblast stem cells to embryonic stem cells and for their maintenance thereafter.
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