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Kruppel-like factor 3

human homolog is a transcription factor; involved in haematopoietic differentiation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, EKLF, SP1, KLF2, V1a
Papers on BKLF
Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain.
Crossley et al., Australia. In Nucleic Acids Res, Jan 2016
We fused the FD from the well-characterized transcription factor Krüppel-like Factor 3 (KLF3) to an artificial zinc finger (AZF) protein originally designed to target the Vascular Endothelial Growth Factor-A (VEGF-A) gene promoter.
C2H2 zinc finger proteins of the SP/KLF, Wilms tumor, EGR, Huckebein, and Klumpfuss families in metazoans and beyond.
Grishin et al., Dallas, United States. In Gene, Dec 2015
The last ancestor of jawed vertebrates was inferred to have at least 18 KLFs (group A: KLF1/2/4/17, group B: KLF3/8/12; group C: KLF5/5l; group D: KLF6/7; group E: KLF9/13/16; group F: KLF10/KLF11; group G: KLF15/15l) and 10 SPs (group A: SP1/2/3/4; group B: SP5/5l; group C: SP6/7/8/9), since they were found in both cartilaginous and boned fishes.
Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
Farrar et al., Minneapolis, United States. In Oncogene, Nov 2015
High-throughput sequencing approaches were used to identify genes frequently targeted by the T2/Onc transposon; these included Sos1 (74%), Kdm2a (35%), Jak1 (26%), Bmi1 (19%), Prdm14 or Ncoa2 (13%), Cdkn2a (10%), Ikzf1 (8%), Caap1 (6%) and Klf3 (6%).
The role of epigenetics in the endothelial cell shear stress response and atherosclerosis.
Jo et al., United States. In Int J Biochem Cell Biol, Oct 2015
Interestingly, among these mechanosensitive genes, the two transcription factors HoxA5 and Klf3 contain cAMP-response-elements (CRE), which may indicate that methylation of CRE sites could serve as a mechanosensitive master switch in gene expression.
Cineromycin B isolated from Streptomyces cinerochromogenes inhibits adipocyte differentiation of 3T3-L1 cells via Krüppel-like factors 2 and 3.
Imamura et al., Kusatsu, Japan. In Life Sci, Sep 2015
Further investigations showed that cineromycin B increased significantly the mRNA expression of two negative regulators of adipocyte differentiation, Krüppel-like factor (KLF) 2 and KLF3, at an early stage of the differentiation.
Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation.
Liu et al., Beijing, China. In Dev Biol, Aug 2015
Loss of function of 2 factors (klf3 or klf6a) leads to a decreased number of mature erythrocytes.
Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis.
Jo et al., Atlanta, United States. In Arterioscler Thromb Vasc Biol, Jul 2015
These studies revealed several mechanosensitive genes, such as HoxA5, Klf3, and Klf4, whose promoters were hypermethylated by disturbed blood flow, but rescued by DNA methyltransferases inhibitors such as 5Aza-2-deoxycytidine.
Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity.
Crossley et al., Sydney, Australia. In J Biol Chem, Apr 2015
Krüppel-like factor 3 (KLF3/BKLF), a member of the Krüppel-like factor (KLF) family of transcription factors, is a widely expressed transcriptional repressor with diverse biological roles.
Protease-activated-receptor 1 polymorphisms correlate with risk for unexplained recurrent pregnancy loss: a pilot study querying an association beyond coagulation.
Bar-Shavit et al., Jerusalem, Israel. In Eur J Obstet Gynecol Reprod Biol, Feb 2015
Bioinformatics indicate generation of a new consensus motif for repressor Kruppel-like factor 3 (KLF3) in [-1426T].
Identification of polymorphisms associated with production traits on chicken (Gallus gallus) chromosome 4.
Coutinho et al., Piracicaba, Brazil. In Genet Mol Res, 2014
Three positional candidate genes were studied: KLF3 (Krüeppel-like factor 3), SLIT2 (Slit homolog 2), and PPARGC1A (peroxisome proliferator-activated receptor gamma, coactivator 1 alpha).
Borrelidin Isolated from Streptomyces sp. Inhibited Adipocyte Differentiation in 3T3-L1 Cells via Several Factors Including GATA-Binding Protein 3.
Imamura et al., In Biol Pharm Bull, 2014
The mRNA expression of PPARγ, which was down-regulated by borrelidin, was not changed by KLF3 and KLF7 siRNA treatment.
The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo.
Crossley et al., Sydney, Australia. In Mol Cell Biol, 2012
KLF3 is a feedback repressor that counters the activity of EKLF at selected target genes to achieve normal erythropoiesis
Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements.
Tamura et al., Chiba, Japan. In Gene, 2012
we concluded that KLF3 is a transcriptional repressor for wee1 gene.
Impaired B cell development in the absence of Krüppel-like factor 3.
Crossley et al., Sydney, Australia. In J Immunol, 2011
B cell differentiation is significantly impaired in the bone marrow, spleen, and peritoneal cavity of Klf3 null mice; the defects are cell autonomous.
Deregulated expression of Kruppel-like factors in acute myeloid leukemia.
Tschan et al., Bern, Switzerland. In Leuk Res, 2011
Low KLF3 is associated with acute myeloid leukemia.
The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF).
Crossley et al., Sydney, Australia. In Iubmb Life, 2011
KLF3 is an important regulator of several biological processes, including adipogenesis, erythropoiesis, and B cell development. (Review)
B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays.
Goodnow et al., San Francisco, United States. In Immunol Rev, 2000
Many genes with known or predicted inhibitory functions are highly expressed in naive, quiescent B cells, notably the signal inhibitor SLAP and DNA-binding proteins of the Kruppel family (LKLF, BKLF, GKLF), Tsc-22, GILZ, Id-3, and GADD45.
Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors.
Crossley et al., Sydney, Australia. In Int J Biochem Cell Biol, 1999
Basic Krüppel-like Factor (BKLF) is a recently recognized member of a small group of transcription factors that bind CACCC motifs in DNA, by means of three highly conserved C-terminal Krüppel-like (typically Cys-X2-4-Cys-X12-His-X3-4-His) zinc fingers.
The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence.
Chambon et al., Strasbourg, France. In Cell, 1988
In contrast, TEF-1 and a second SV40 enhancer binding protein, TEF-2, bind independently to templates containing the cognate motifs of both proteins (GT-I and either GT-IIC or Sph motifs) even though these motifs cooperate in enhancer activity in vivo.
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