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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

E74-like factor 3

BIRC5, ELF3, Jen, ESE-1, EPR-1, ESX
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: Esx1, CAN, V1a, HAD, ACID
Papers on BIRC5
Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple negative breast cancer.
New
Sukumar et al., Hopkins, United States. In Cancer Res, Feb 2016
Furthermore, gene expression analysis revealed that the epithelium-specific ETS transcription factor-1 (ESE-1 or ELF3), known to regulate proliferation and differentiation, enhanced cell differentiation in response to EAD triple therapy.
Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.
New
Jacobs et al., Shanghai, China. In Proc Natl Acad Sci U S A, Feb 2016
Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS), designated ESX-1-ESX-5, that are critical for growth and pathogenesis.
Mycobacterial pan-genome analysis suggests important role of plasmids in the radiation of type VII secretion systems.
New
Sapriel et al., Saint-Quentin, France. In Genome Biol Evol, Feb 2016
UNASSIGNED: In mycobacteria, various type VII secretion systems corresponding to different ESX (ESAT-6 secretory) types, are contributing to pathogenicity, iron acquisition, and/or conjugation.
Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells.
New
Lau et al., Shantou, China. In Oncotarget, Jan 2016
Moreover, there was an induction of proapoptotic protein BAX, release of cytochrome c (CYCS) from mitochondria, activation of caspase-3/9 (CASP3/9); as well as decreased expression of cell cycle checkpoint proteins (TP53, p21, and p27) and several inhibitors of apoptosis proteins (IAPs) [including cIAP-1/2 (BIRC2/3), XIAP (BIRC4), and survivin (BIRC5)].
Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche.
New
Weghorst et al., Davao, Philippines. In Cancer Prev Res (phila), Jan 2016
Following BRB troche administration, the expression of pro-survival genes (AURKA, BIRC5, EGFR) and pro-inflammatory genes (NFKB1, PTGS2) were significantly reduced.
Genomic spectra of biliary tract cancer.
New
Impact
Shibata et al., Tokyo, Japan. In Nat Genet, Sep 2015
Thirty-two significantly altered genes, including ELF3, were identified, and nearly 40% of cases harbored targetable genetic alterations.
Immunoregulatory functions and expression patterns of PE/PPE family members: Roles in pathogenicity and impact on anti-tuberculosis vaccine and drug design.
Review
New
Mukhopadhyay et al., Hyderābād, India. In Iubmb Life, Jun 2015
In this review, we discuss PE/PPE proteins, their close functional association with the ESX clusters, their immunomodulatory functions, and their important roles in mycobacterial virulence.
Release of mycobacterial antigens.
Review
New
Brosch et al., Paris, France. In Immunol Rev, Mar 2015
Here, we discuss recently discovered, novel aspects on the nature and the regulation of antigen release of the tuberculosis agent with particular emphasis on the biological characterization of mycobacteria-specific ESX/type VII secretion systems and their secreted proteins, belonging to the Esx, PE, and PPE categories.
Landscape of genomic alterations in cervical carcinomas.
Impact
Meyerson et al., Boston, United States. In Nature, 2014
We also observe somatic ELF3 (13%) and CBFB (8%) mutations in 24 adenocarcinomas.
Mycobacterial Pathogenomics and Evolution.
Review
Brosch et al., In Microbiol Spectr, 2014
Comparison of virulent and attenuated members of the M. tuberculosis complex has further contributed to identification of a specific secretion pathway, named ESX or Type VII secretion.
Distributive Conjugal Transfer: New Insights into Horizontal Gene Transfer and Genetic Exchange in Mycobacteria.
Review
Gray et al., In Microbiol Spectr, 2014
The mating identity genes map to the esx1 locus, expanding the central role of ESX-1 function in conjugation.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Impact
Hahn et al., Boston, United States. In Cell, 2013
Phosphorylation of YAP1 by the tyrosine kinase YES1 leads to localization of this complex to the promoters of antiapoptotic genes, including BCL2L1 and BIRC5.
ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question.
Review
Pardo et al., Zaragoza, Spain. In Front Cell Infect Microbiol, 2012
The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis.
Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells.
GeneRIF
Nishida et al., Ōsaka, Japan. In Leuk Res, 2012
Overexpression of survivin is associated with multidrug-resistance in multiple myeloma.
The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability.
GeneRIF
Battafarano et al., Baltimore, United States. In Biochem J, 2012
CUG-BP1 associates with the 3'-untranslated region of survivin mRNA, thereby stabilizing the transcript and elevating its expression in oesophageal cancer cells.
Co-silencing of Birc5 (survivin) and Hspa5 (Grp78) induces apoptosis in hepatoma cells more efficiently than single gene interference.
GeneRIF
Lei et al., Wuhan, China. In Int J Oncol, 2012
Birc5 and Hspa5 could be important survival factors for hepatoma carcinoma cells
Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML.
GeneRIF
Kornblau et al., Houston, United States. In Blood, 2012
Survivin expression correlated with the expressions of multiple proteins involved with cell proliferation and survival.
Overexpression of βIII-tubulin and survivin associated with drug resistance to docetaxel-based chemotherapy in advanced gastric cancer.
GeneRIF
Chen et al., Wenzhou, China. In J Buon, 2012
Overexpression of survivin is associated with drug resistance to docetaxel-based chemotherapy in advanced gastric cancer.
The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth.
Impact
GeneRIF
Kay et al., San Diego, United States. In Nature, 2011
identification of a protein complex composed of the proteins encoded by EARLY FLOWERING 3 (ELF3), ELF4 and the transcription-factor-encoding gene LUX ARRHYTHMO (LUX; also known as PHYTOCLOCK 1)--that directly regulates plant growth
The anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cells.
Impact
GeneRIF
Benvenisty et al., Jerusalem, Israel. In Nat Biotechnol, 2009
We suggest that continued expression of survivin upon differentiation in vivo may contribute to teratoma formation by hES cells.
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