Genomic spectra of biliary tract cancer.
Tokyo, Japan. In Nat Genet, Sep 2015
Thirty-two significantly altered genes, including ELF3, were identified, and nearly 40% of cases harbored targetable genetic alterations.
An Old Flame Never Dies: Survivin in Cancer and Cellular Senescence.
Essen, Germany. In Gerontology, Aug 2015
UNASSIGNED: Survivin (BIRC5) is highly expressed in the vast majority of human cancers and is associated with chemotherapy resistance, increased tumor recurrence and shortened patient survival, making it an attractive therapeutic target.
Release of mycobacterial antigens.
Paris, France. In Immunol Rev, Mar 2015
Here, we discuss recently discovered, novel aspects on the nature and the regulation of antigen release of the tuberculosis agent with particular emphasis on the biological characterization of mycobacteria-specific ESX/type VII secretion systems and their secreted proteins, belonging to the Esx, PE, and PPE categories.
Mycobacterial Pathogenomics and Evolution.
In Microbiol Spectr, 2014
Comparison of virulent and attenuated members of the M. tuberculosis complex has further contributed to identification of a specific secretion pathway, named ESX or Type VII secretion.