MicroRNAs as novel nutrigenomic targets for cardiovascular health.
Clermont-Ferrand, France. In Free Radic Biol Med, 2014
These miRNAs could exert post-transcriptional regulation by inhibiting protein synthesis, as BIRC2, or by inducing mRNA degradation, as WASP1.These data suggest that miRNAs are important molecular targets of flavanol metabolites involved in the regulation of expression of genes controlling adhesion and transendothelial migration processes.
Inhibitors of apoptotic proteins: new targets for anticancer therapy.
Faisalābād, Pakistan. In Chem Biol Drug Des, 2013
There are eight proteins in this family: NAIP/BIRC1/NLRB, cellular IAP1 (cIAP1)/human IAP2/BIRC2, cellular IAP2 (cIAP2)/human IAP1/BIRC3, X-linked IAP (XIAP)/BIRC4, survivin/BIRC5, baculoviral IAP repeat (BIR)-containing ubiquitin-conjugating enzyme/apollon/BIRC6, livin/melanoma-IAP (ML-IAP)/BIRC7/KIAP, and testis-specific IAP (Ts-IAP)/hILP-2/BIRC8.
Keeping your vascular integrity: What can we learn from fish?
Leuven, Belgium. In Bioessays, 2008
The zebrafish has emerged as a formidable tool to speed up this quest, as illustrated in a recent issue of Nature Genetics.1 Baculovirus IAP repeat c2 (BIRC2), also termed cellular inhibitor of apoptosis (cIAP)-1, was found to specifically prevent endothelial cells (ECs, lining the inside of vessels) from going into suicide mode ('apoptosis') and so preserve vessel integrity.