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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Baculoviral IAP repeat-containing 2

birc2, inhibitor of apoptosis protein-2, rIAP-I, RIAP1
may play a role in regulation of apoptosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: cIAP2, PrP, CAN, caspase-3, V1a
Papers on birc2
Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells.
New
Lau et al., Shantou, China. In Oncotarget, Jan 2016
Moreover, there was an induction of proapoptotic protein BAX, release of cytochrome c (CYCS) from mitochondria, activation of caspase-3/9 (CASP3/9); as well as decreased expression of cell cycle checkpoint proteins (TP53, p21, and p27) and several inhibitors of apoptosis proteins (IAPs) [including cIAP-1/2 (BIRC2/3), XIAP (BIRC4), and survivin (BIRC5)].
Supportive or detrimental roles of P2Y receptors in brain pathology?-The two faces of P2Y receptors in stroke and neurodegeneration detected in neural cell and in animal model studies.
New
Reiser et al., Magdeburg, Germany. In Purinergic Signal, Dec 2015
The mechanisms reported to underlie the protection in vitro include increased expression of oxidoreductase genes, like carbonyl reductase and thioredoxin reductase; increased expression of inhibitor of apoptosis protein-2; extracellular signal-regulated kinase- and Akt-mediated antiapoptotic signaling; increased expression of Bcl-2 proteins, neurotrophins, neuropeptides, and growth factors; decreased Bax expression; non-amyloidogenic APP shedding; and increased neurite outgrowth in neuronal cells.
Integrating ChIP-sequencing and digital gene expression profiling to identify BRD7 downstream genes and construct their regulating network.
New
Zeng et al., Changsha, China. In Mol Cell Biochem, Oct 2015
Furthermore, we validated BIRC2, BIRC3, TXN2, and NOTCH1 genes as direct, functional BRD7 targets, which were involved in the cell cycle and apoptosis pathways.
BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.
New
Chanda et al., Los Angeles, United States. In Cell Host Microbe, Oct 2015
Employing a targeted RNAi screen, we identified the ubiquitin ligase BIRC2 (cIAP1), a repressor of the noncanonical NF-κB pathway, as a potent negative regulator of LTR-dependent HIV-1 transcription.
Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-κB-activating potential.
New
Mano et al., Tokyo, Japan. In Cancer Sci, Sep 2015
BIRC2 and BIRC3 are closely related members of the inhibitor of apoptosis (IAP) family of proteins and play pivotal roles in regulation of nuclear factor-κB (NF-κB) signaling and apoptosis.
RUNX3 contributes to carboplatin resistance in epithelial ovarian cancer cells.
New
Fu et al., Edmonton, Canada. In Gynecol Oncol, Sep 2015
The expression of cellular inhibitor of apoptosis protein-2 (cIAP2) and its regulation by RUNX3 were assessed by quantitative RT-PCR and Western blotting.
Environmental carcinogens and mutational pathways in atherosclerosis.
Review
New
Izzotti et al., Genova, Italy. In Int J Hyg Environ Health, May 2015
Mitochondrial damage is a main endogenous source of oxidative stress whose accumulation causes activation of intrinsic apoptosis through BIRC2 inhibition and cell loss contributing to plaque development and instability.
Aminomethylphosphonic acid and methoxyacetic acid induce apoptosis in prostate cancer cells.
You et al., In Int J Mol Sci, 2014
Importantly, the AMPA-induced apoptosis was potentiated with the addition of MAA, which was due to downregulation of the anti-apoptotic gene baculoviral inhibitor of apoptosis protein repeat containing 2 (BIRC2), leading to activation of caspases 7 and 3.
GC-Rich Extracellular DNA Induces Oxidative Stress, Double-Strand DNA Breaks, and DNA Damage Response in Human Adipose-Derived Mesenchymal Stem Cells.
Veiko et al., Moscow, Russia. In Oxid Med Cell Longev, 2014
As a result in the cells significantly increases the expression of repair genes (BRCA1 (RT-PCR), PCNA (FACS)) and antiapoptotic genes (BCL2 (RT-PCR and FACS), BCL2A1, BCL2L1, BIRC3, and BIRC2 (RT-PCR)).
MicroRNAs as novel nutrigenomic targets for cardiovascular health.
Milenkovic, Clermont-Ferrand, France. In Free Radic Biol Med, 2014
These miRNAs could exert post-transcriptional regulation by inhibiting protein synthesis, as BIRC2, or by inducing mRNA degradation, as WASP1.These data suggest that miRNAs are important molecular targets of flavanol metabolites involved in the regulation of expression of genes controlling adhesion and transendothelial migration processes.
Inhibitors of apoptotic proteins: new targets for anticancer therapy.
Review
Ahmad et al., Faisalābād, Pakistan. In Chem Biol Drug Des, 2013
There are eight proteins in this family: NAIP/BIRC1/NLRB, cellular IAP1 (cIAP1)/human IAP2/BIRC2, cellular IAP2 (cIAP2)/human IAP1/BIRC3, X-linked IAP (XIAP)/BIRC4, survivin/BIRC5, baculoviral IAP repeat (BIR)-containing ubiquitin-conjugating enzyme/apollon/BIRC6, livin/melanoma-IAP (ML-IAP)/BIRC7/KIAP, and testis-specific IAP (Ts-IAP)/hILP-2/BIRC8.
Inhibitors of apoptosis proteins (IAPs) as potential molecular targets for therapy of hematological malignancies.
Review
Robak et al., Łódź, Poland. In Curr Mol Med, 2011
The following IAPs have been described so far: NAIP (neuronal apoptosis inhibitory protein; BIRC1), cIAP1 and cIAP2 (cellular inhibitor of apoptosis 1 and 2; BIRC2 and BIRC3, respectively), XIAP (X-chromosome binding IAP; BIRC4), survivin (BIRC5), BRUCE (Apollon; BIRC6), livin (BIRC7) and Ts-IAP (testis-specific IAP; BIRC8).
Keeping your vascular integrity: What can we learn from fish?
Review
Verhamme et al., Leuven, Belgium. In Bioessays, 2008
The zebrafish has emerged as a formidable tool to speed up this quest, as illustrated in a recent issue of Nature Genetics.1 Baculovirus IAP repeat c2 (BIRC2), also termed cellular inhibitor of apoptosis (cIAP)-1, was found to specifically prevent endothelial cells (ECs, lining the inside of vessels) from going into suicide mode ('apoptosis') and so preserve vessel integrity.
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.
Impact
Stainier et al., San Francisco, United States. In Nat Genet, 2007
Here, we show that Birc2 (also known as cIap1) is essential for maintaining endothelial cell survival and blood vessel homeostasis during vascular development.
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.
Impact
Staudt et al., Bethesda, United States. In Cancer Cell, 2007
A majority of primary myeloma patient samples and cell lines had elevated NF-kappaB target gene expression, often associated with genetic or epigenetic alteration of NIK, TRAF3, CYLD, BIRC2/BIRC3, CD40, NFKB1, or NFKB2.
Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2.
GeneRIF
Venkatachalam et al., Augusta, United States. In Am J Pathol, 2003
Data show that death resistance of hypoxic cells involves multiple factors targeting different stages of apoptosis, with inhibitor of apoptosis protein-2 suppressing caspases in the cytosol.
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