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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Bridging integrator 1

Bin1, amphiphysin II, amphiphysin 2
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Amphiphysin, Clusterin, apolipoprotein E, Dynamin I, HAD
Papers using Bin1 antibodies
Colocalization of fluorescent markers in confocal microscope images of plant cells.
Supplier
Chien Kenneth R., In PLoS Biology, 2007
... Human BIN1 (Isotype 8) cDNA was obtained from Origene.
Papers on Bin1
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD.
New
Ertekin-Taner et al., Rochester, United States. In Neurology, 26 Apr 2014
No other locus was significant after corrections for multiple testing, although rs11136000 near CLU (p = 0.019, OR = 0.60) and rs744373 near BIN1 (p = 0.025, OR = 1.
The Benefits of Staying Active in Old Age: Physical Activity Counteracts the Negative Influence of PICALM, BIN1, and CLU Risk Alleles on Episodic Memory Functioning.
New
Bäckman et al., In Psychol Aging, 24 Apr 2014
UNLABELLED: PICALM, BIN1, CLU, and APOE are top candidate genes for Alzheimer's disease, and they influence episodic memory performance in old age.
Amphiphysin 2 (BIN1) in physiology and diseases.
New
Laporte et al., Illkirch-Graffenstaden, France. In J Mol Med (berl), 05 Apr 2014
UNLABELLED: Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, has been recently implicated in rare and common diseases affecting different tissues and physiological functions.
Dynamin 2 the rescue for centronuclear myopathy.
New
McNally et al., In J Clin Invest, 03 Apr 2014
The most severe form of the disease, X-linked centronuclear myopathy, is due to mutations in the gene encoding myotubularin (MTM1), while mutations in dynamin 2 (DNM2) and amphiphysin 2/BIN1 (AMPH2) cause milder forms of myopathy.
Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals.
New
Tan et al., Qingdao, China. In Neurobiol Aging, 06 Mar 2014
UNLABELLED: Genome-wide association studies have identified the bridging integrator 1 (BIN1) gene as the most important genetic susceptibility locus in late-onset Alzheimer's disease (LOAD) after apolipoprotein E for individuals of European ancestry.
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
New
Impact
Alzheimer Disease Genetics Consortium et al., New York City, United States. In Jama, May 2013
Several loci previously associated with Alzheimer disease but not reaching significance in genome-wide analyses were replicated in gene-based analyses accounting for linkage disequilibrium between markers and correcting for number of tests performed per gene (CR1, BIN1, EPHA1, CD33; 0.0005 < empirical P < .001).
The genetics and neuropathology of Alzheimer's disease.
Review
Montine et al., Philadelphia, United States. In Acta Neuropathol, 2012
This work, so far accomplished through single nucleotide polymorphism arrays, has revealed nine new genes implicated in AD risk (ABCA7, BIN1, CD33, CD2AP, CLU, CR1, EPHA1, MS4A4E/MS4A6A, and PICALM).
Bin1 attenuation suppresses experimental colitis by enforcing intestinal barrier function.
GeneRIF
Prendergast et al., United States. In Dig Dis Sci, 2012
Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions.
Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.
GeneRIF
Roberts et al., Boston, United States. In Cell Cycle, 2012
The re-expression of BIN1 specifically compromises the proliferation of SNF5-deficient rhabdoid tumors cell lines.
Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.
GeneRIF
National Institute on Aging Late-Onset Alzheimer's Disease Genetics Study et al., New York City, United States. In Neurology, 2012
The SNP genotype pattern at the BIN1 gene is associated with episodic memory.
Characterization of bridging integrator 1 (BIN1) as a potential tumor suppressor and prognostic marker in hepatocellular carcinoma.
GeneRIF
Xia et al., Guangzhou, China. In Mol Med, 2011
BIN1 expression is significantly decreased in surgically excised hepatocellular carcinoma patient specimens as well as in HCC cell lines and decreased BIN1 expression correlates with the degree of differentiation of HCC and predicts poor prognosis.
Defective membrane remodeling in neuromuscular diseases: insights from animal models.
Review
Laporte et al., Illkirch-Graffenstaden, France. In Plos Genet, 2011
Mutations in myotubularin, amphiphysin 2 (BIN1), and dynamin 2 lead to different forms of centronuclear myopathy, while mutations in myotubularin-related proteins cause Charcot-Marie-Tooth neuropathies.
The genetics of Alzheimer's disease.
Review
Barber, Fort Worth, United States. In Scientifica (cairo), 2011
Examples that have been confirmed by multiple studies include ABCA7, APOE, BIN1, CD2AP, CD33, CLU, CR1, EPHA1, MS4A4A/MS4A4E/MS4A6E, PICALM, and SORL1.
Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.
Impact
GeneRIF
Charlet-Berguerand et al., Illkirch-Graffenstaden, France. In Nat Med, 2011
alternative splicing associated with T tubule alterations and muscle weakness in myotonic dystrophy
Genetics of Alzheimer's disease: new evidences for an old hypothesis?
Review
Amouyel et al., Lille, France. In Curr Opin Genet Dev, 2011
In addition to APOE, a major recognized genetic determinant of AD, systematic, high-throughput genomic approaches have recently allowed the characterization of four new genetic determinants: CLU, CR1, PICALM and BIN1.
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Impact
Schellenberg et al., Miami, United States. In Nat Genet, 2011
We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.
GeneRIF
Ma et al., United States. In Plos One, 2010
Study showing the importance of Bin1 in the maintenance of intact t-tubule structure and ([Ca(2)]i) homeostasis in adult skeletal muscle could provide insight on the potential role of Bin1 in skeletal muscle contractility and pathology of myopathy.
MYC, PARP1, and chemoresistance: BIN there, done that?
Review
GeneRIF
Ganesan, New Brunswick, United States. In Sci Signal, 2010
A model has been proposed in which increased abundance of c-MYC indirectly leads to decreased BIN1 expression, in turn leading to increased PARP activity and resistance to DNA-damaging agents.
Genome-wide analysis of genetic loci associated with Alzheimer disease.
Impact
EADI1 Consortium et al., Boston, United States. In Jama, 2010
RESULTS: Two loci were identified to have genome-wide significance for the first time: rs744373 near BIN1 (odds ratio [OR],1.13;
AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling.
Impact
GeneRIF
Grant et al., United States. In Nat Cell Biol, 2009
show a requirement for human BIN1 (also known as Amphiphysin 2) in EHD1-regulated endocytic recycling.
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