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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Bridging integrator 1

Bin1, amphiphysin II, amphiphysin 2
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Amphiphysin, Clusterin, apolipoprotein E, Dynamin I, HAD
Papers using Bin1 antibodies
Colocalization of fluorescent markers in confocal microscope images of plant cells.
Supplier
Chien Kenneth R., In PLoS Biology, 2007
... Human BIN1 (Isotype 8) cDNA was obtained from Origene.
Papers on Bin1
Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance.
New
Becker et al., Bonn, Germany. In Neurobiol Dis, 29 Feb 2016
In a subsequent promoter analysis, we found the single nucleotide polymorphism rs744373 C-allele to be associated with high mRNA levels of bridging integrator 1 (BIN1)/Amphiphysin 2, i.e. a major component of the endocytotic machinery and located in a crucial genetic AD risk locus.
Association Between Interleukin-1A, Interleukin-1B, and Bridging integrator 1 Polymorphisms and Alzheimer's Disease: a standard and Cumulative Meta-analysis.
New
Gao et al., Tangshan, China. In Mol Neurobiol, 15 Feb 2016
Bridging integrator 1 (BIN1) is considered as common genetic risk factors for AD, whereas different studies have provided various conclusions regarding its role in AD.
Lower Prevalence of Alzheimer's Disease among Tibetans: Association with Religious and Genetic Factors.
New
Hu et al., Beijing, China. In J Alzheimers Dis, 06 Feb 2016
MALDI-TOF was used to test the genotypes of CLU, TFAM, TP53INP1, IGHV1-67, CR1, ApoE, and BIN1.
GWAS-Linked Loci and Neuroimaging Measures in Alzheimer's Disease.
New
Alzheimer’s Disease Neuroimaging Initiative et al., Qingdao, China. In Mol Neurobiol, 05 Feb 2016
Meanwhile, rs11218343 at SORL1 and rs6733839 at BIN1 was associated with rate of volume change of left parahippocampal and right inferior parietal, respectively.
Isoproterenol Promotes Rapid Ryanodine Receptor Movement to BIN1 Organized Dyads.
New
Hong et al., Los Angeles, United States. In Circulation, 05 Feb 2016
Given that BIN1 (Bridging Integrator 1) organizes t-tubule microfolds and facilitates CaV1.2 delivery, we explored whether β-AR regulated RyRs are also affected by BIN1.
Association study of the BIN1 and IL-6 genes on Alzheimer's disease.
New
de Paula et al., Vitória, Brazil. In Neurosci Lett, 27 Jan 2016
Among them, the BIN1 gene is involved in endocytosis and intracellular trafficking as well as in the formation of β amyloid plaques and neurofibrillary tangles, which are the main pathological hallmarks of AD.
Relationship between Alzheimer's disease GWAS-linked top hits and risk of Parkinson's disease with or without cognitive decline: a Chinese population-based study.
New
Guo et al., Changsha, China. In Neurobiol Aging, 07 Jan 2016
To examine whether there is a genetic link for these diseases, we performed a case-control study in Chinese population to evaluate the association of AD genome-wide association studies top hits with both PD and cognitive function in PD, investigating 13 single-nucleotide polymorphisms in 9 genes (BIN1, CLU, ABCA7, CR1, PICALM, MS4A6A, CD33, MS4A4E, and CD2AP).
BIN1 regulates dynamic t-tubule membrane.
New
Hong et al., Los Angeles, United States. In Biochim Biophys Acta, 11 Dec 2015
In this review, we focus primarily on two proteins concentrated within the t-tubular network, the L-type calcium channel (LTCC) and associated membrane anchor protein, bridging integrator 1 (BIN1).
Potential genetic biomarkers in the early diagnosis of Alzheimer disease: APOE and BIN1.
Gündüz et al., In Turk J Med Sci, 2014
According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene.
Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
Shen et al., Changsha, China. In Plos One, 2014
Risk SNPs included rs9331888 (CLU), rs6691117 (CR1), rs4938933 (MS4A), rs9349407 (CD2AP), rs1160985 (TOMM40), rs4945261 (GAB2) and rs5984894 (PCDH11X); Protective SNPs consisted of rs744373 (BIN1), rs1562990 (MS4A), rs597668 (EXOC3L2), rs9271192 (HLA-DRB5/DRB1), rs157581 and rs11556505 (TOMM40).
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
Impact
Shaw et al., Los Angeles, United States. In Nat Med, 2014
Bridging integrator 1 (BIN1) is a T-tubule protein associated with calcium channel trafficking that is downregulated in failing hearts.
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
Impact
Alzheimer Disease Genetics Consortium et al., New York City, United States. In Jama, 2013
Several loci previously associated with Alzheimer disease but not reaching significance in genome-wide analyses were replicated in gene-based analyses accounting for linkage disequilibrium between markers and correcting for number of tests performed per gene (CR1, BIN1, EPHA1, CD33; 0.0005 < empirical P < .001).
Bin1 attenuation suppresses experimental colitis by enforcing intestinal barrier function.
GeneRIF
Prendergast et al., United States. In Dig Dis Sci, 2012
Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions.
Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.
GeneRIF
Roberts et al., Boston, United States. In Cell Cycle, 2012
The re-expression of BIN1 specifically compromises the proliferation of SNF5-deficient rhabdoid tumors cell lines.
Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.
GeneRIF
National Institute on Aging Late-Onset Alzheimer's Disease Genetics Study et al., New York City, United States. In Neurology, 2012
The SNP genotype pattern at the BIN1 gene is associated with episodic memory.
Characterization of bridging integrator 1 (BIN1) as a potential tumor suppressor and prognostic marker in hepatocellular carcinoma.
GeneRIF
Xia et al., Guangzhou, China. In Mol Med, 2011
BIN1 expression is significantly decreased in surgically excised hepatocellular carcinoma patient specimens as well as in HCC cell lines and decreased BIN1 expression correlates with the degree of differentiation of HCC and predicts poor prognosis.
Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.
Impact
GeneRIF
Charlet-Berguerand et al., Illkirch-Graffenstaden, France. In Nat Med, 2011
alternative splicing associated with T tubule alterations and muscle weakness in myotonic dystrophy
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Impact
Schellenberg et al., Miami, United States. In Nat Genet, 2011
We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.
GeneRIF
Ma et al., United States. In Plos One, 2010
Study showing the importance of Bin1 in the maintenance of intact t-tubule structure and ([Ca(2)]i) homeostasis in adult skeletal muscle could provide insight on the potential role of Bin1 in skeletal muscle contractility and pathology of myopathy.
Genome-wide analysis of genetic loci associated with Alzheimer disease.
Impact
EADI1 Consortium et al., Boston, United States. In Jama, 2010
RESULTS: Two loci were identified to have genome-wide significance for the first time: rs744373 near BIN1 (odds ratio [OR],1.13;
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