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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Mar 2015.

Bridging integrator 1

Bin1, amphiphysin II, amphiphysin 2
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Amphiphysin, Clusterin, apolipoprotein E, Dynamin I, HAD
Papers using Bin1 antibodies
Colocalization of fluorescent markers in confocal microscope images of plant cells.
Supplier
Chien Kenneth R., In PLoS Biology, 2007
... Human BIN1 (Isotype 8) cDNA was obtained from Origene.
Papers on Bin1
Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.
New
Debette et al., Bordeaux, France. In Neurobiol Aging, 30 Apr 2015
In gene-based tests, there was associations of HLA-DRB1 with total brain volume (p = 0.0006) and BIN1 with HV (p = 0.00089).
A fluorescent live imaging screening assay based on translocation criteria identifies novel cytoplasmic proteins implicated in GPCR signalling pathways.
New
Galzi et al., Strasbourg, France. In Mol Cell Proteomics, 10 Apr 2015
The proteins BAIAP3 and BIN1, partially translocated to the plasma membrane upon activation of NK2 receptors.
Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume and Functional Connectivity in Young Healthy Individuals.
New
Jiang et al., Beijing, China. In Neuropsychopharmacology, 01 Mar 2015
The bridging integrator 1 (BIN1) gene has recently been identified in several large genome-wide association studies (GWAS) as the second most important risk locus for AD following apolipoprotein E (APOE).
Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing.
New
Mizuguchi et al., Beijing, China. In Plos One, Dec 2014
In addition, some of the pathways identified as regulators of APP processing contain genes (CLU, BIN1, CR1, PICALM, TREM2, SORL1, MEF2C, DSG2, EPH1A) recently implicated with AD through genome wide association studies (GWAS) and associated meta-analysis.
Recruitment of coat proteins to liposomes and peptidoliposomes.
New
Spiess et al., Basel, Switzerland. In Methods Mol Biol, Dec 2014
Without cargo peptides, accessory proteins, such as amphiphysin 2, can be identified that stabilize AP-1 binding to liposomal membranes.
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
New
Impact
Shaw et al., Los Angeles, United States. In Nat Med, Jun 2014
Bridging integrator 1 (BIN1) is a T-tubule protein associated with calcium channel trafficking that is downregulated in failing hearts.
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.
Review
New
Alzheimer’s Disease Neuroimaging Initiative et al., Indianapolis, United States. In Brain Imaging Behav, Jun 2014
Major ADNI findings included all the top 10 AD genes and several of these (e.g., APOE, BIN1, CLU, CR1, and PICALM) were corroborated by ADNI imaging, fluid and cognitive phenotypes.
Amphiphysin 2 (BIN1) in physiology and diseases.
Review
New
Laporte et al., Illkirch-Graffenstaden, France. In J Mol Med (berl), May 2014
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, has been recently implicated in rare and common diseases affecting different tissues and physiological functions.
Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways.
Review
Kamboh et al., Pittsburgh, United States. In Curr Genet Med Rep, 2013
In addition to APOE, recent large genome-wide association studies have identified variation in over 20 loci that contribute to disease risk: CR1, BIN1, INPP5D, MEF2C, TREM2, CD2AP, HLA-DRB1/HLA-DRB5, EPHA1, NME8, ZCWPW1, CLU, PTK2B, PICALM, SORL1, CELF1, MS4A4/MS4A6E, SLC24A4/RIN3,FERMT2, CD33, ABCA7, CASS4.
Pathogenic mechanisms in centronuclear myopathies.
Review
Gautel et al., London, United Kingdom. In Front Aging Neurosci, 2013
The most common forms of congenital myopathies with central nuclei have been attributed to X-linked recessive mutations in the MTM1 gene encoding myotubularin ("X-linked myotubular myopathy"), autosomal-dominant mutations in the DNM2 gene encoding dynamin-2 and the BIN1 gene encoding amphiphysin-2 (also named bridging integrator-1, BIN1, or SH3P9), and autosomal-recessive mutations in BIN1, the RYR1 gene encoding the skeletal muscle ryanodine receptor, and the TTN gene encoding titin.
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
Impact
Alzheimer Disease Genetics Consortium et al., New York City, United States. In Jama, 2013
Several loci previously associated with Alzheimer disease but not reaching significance in genome-wide analyses were replicated in gene-based analyses accounting for linkage disequilibrium between markers and correcting for number of tests performed per gene (CR1, BIN1, EPHA1, CD33; 0.0005 < empirical P < .001).
Bin1 attenuation suppresses experimental colitis by enforcing intestinal barrier function.
GeneRIF
Prendergast et al., United States. In Dig Dis Sci, 2012
Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions.
Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.
GeneRIF
Roberts et al., Boston, United States. In Cell Cycle, 2012
The re-expression of BIN1 specifically compromises the proliferation of SNF5-deficient rhabdoid tumors cell lines.
Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.
GeneRIF
National Institute on Aging Late-Onset Alzheimer's Disease Genetics Study et al., New York City, United States. In Neurology, 2012
The SNP genotype pattern at the BIN1 gene is associated with episodic memory.
Characterization of bridging integrator 1 (BIN1) as a potential tumor suppressor and prognostic marker in hepatocellular carcinoma.
GeneRIF
Xia et al., Guangzhou, China. In Mol Med, 2011
BIN1 expression is significantly decreased in surgically excised hepatocellular carcinoma patient specimens as well as in HCC cell lines and decreased BIN1 expression correlates with the degree of differentiation of HCC and predicts poor prognosis.
The genetics of Alzheimer's disease.
Review
Barber, Fort Worth, United States. In Scientifica (cairo), 2011
Examples that have been confirmed by multiple studies include ABCA7, APOE, BIN1, CD2AP, CD33, CLU, CR1, EPHA1, MS4A4A/MS4A4E/MS4A6E, PICALM, and SORL1.
Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.
Impact
GeneRIF
Charlet-Berguerand et al., Illkirch-Graffenstaden, France. In Nat Med, 2011
alternative splicing associated with T tubule alterations and muscle weakness in myotonic dystrophy
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Impact
Schellenberg et al., Miami, United States. In Nat Genet, 2011
We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.
GeneRIF
Ma et al., United States. In Plos One, 2010
Study showing the importance of Bin1 in the maintenance of intact t-tubule structure and ([Ca(2)]i) homeostasis in adult skeletal muscle could provide insight on the potential role of Bin1 in skeletal muscle contractility and pathology of myopathy.
Genome-wide analysis of genetic loci associated with Alzheimer disease.
Impact
EADI1 Consortium et al., Boston, United States. In Jama, 2010
RESULTS: Two loci were identified to have genome-wide significance for the first time: rs744373 near BIN1 (odds ratio [OR],1.13;
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