Necrotic death as a cell fate.
In PLoS ONE, 2005
... Predesigned FOXO3a siRNA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA), and Bim and control siRNA were from Qiagene (Valencia, CA).
Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contextsmore suppliers
In Breast Cancer Research : BCR, 2001
... (Santa Cruz, Santa Cruz, CA, USA), phosphorylated AKT (S473), cleaved caspase 3, Bim and Bim (IF specific) (Cell Signaling, Beverly, MA, USA), p27 ...
A synthetic chalcone, 2'-hydroxy-2,3,5'-trimethoxychalcone triggers unfolded protein response-mediated apoptosis in breast cancer cells.
Seoul, South Korea. In Cancer Lett, Jan 2016
Further analysis revealed that DK143 produced reactive oxygen species (ROS) in MDA-MB-231 cells, but not in MCF10A cells, and upregulated the expression of ER stress sensors, including GRP78/BiP, IRE1α, CHOP, and Bim in MDA-MB-231 cells.
Cell death induced by endoplasmic reticulum stress.
l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
These proteins aim to restore homeostasis, but they can also induce cell death, which has been shown to occur by necroptosis and, more commonly, through the regulation of Bcl-2 family proteins (Bim, Noxa and Puma) that leads to mitochondrial apoptosis.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
Kettering, United States. In Nat Cell Biol, Oct 2015
Using combinatorial gain-of-function and loss-of-function approaches in Bid(-/-)Bim(-/-)Puma(-/-)Noxa(-/-) and Bax(-/-)Bak(-/-) cells, we have constructed an interconnected hierarchical model that accommodates and explains how the intricate interplays between the BCL-2 members dictate cellular survival versus death.
Regulation of Bim in Health and Disease.
Jerusalem, Israel. In Oncotarget, Oct 2015
The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway under both physiological and pathophysiological conditions.
Melatonin as a proteasome inhibitor. Is there any clinical evidence?
More papers using
Winnipeg, Canada. In Life Sci, 2014
Proteasome inhibitors and melatonin are both intimately involved in the regulation of major signal transduction proteins including p53, cyclin p27, transcription factor NF-κB, apoptotic factors Bax and Bim, caspase 3, caspase 9, anti-apoptotic factor Bcl-2, TRAIL, NRF2 and transcription factor beta-catenin.