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BMP2 inducible kinase

Bike, BMP2K
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on Bike
A novel genetic variant of BMP2K contributes to high myopia.
Tsai et al., Taiwan. In J Clin Lab Anal, 2008
BMP2K gene 1379 G/A variant is strongly correlated with high myopia and may contribute to a genetic risk factor for high degrees of myopic pathogenesis.
BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study.
Uitterlinden et al., Rotterdam, Netherlands. In J Bone Miner Res, 2006
The association of the BMP-2 gene polymorphisms Ser37Ala and Arg190Ser with osteoporosis in 6353 men and women from the Rotterdam Study was studied.
Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells.
Morita et al., Tokyo, Japan. In J Cell Physiol, 2004
PGE2 produced by COX-2 increased BMP-2 expression via binding the EP4 receptor.
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