Epilepsy associated with autism and attention deficit hyperactivity disorder: is there a genetic link?
Roma, Italy. In Brain Dev, 2014
The majority of the candidate genes are involved in synaptic formation/remodeling/maintenance (NRX1, CNTN4, DCLK2, CNTNAP2, TRIM32, ASTN2, CTNTN5, SYN1), neurotransmission (SYNGAP1, GABRG1, CHRNA7), or DNA methylation/chromatin remodeling (MBD5).
Contactins in the neurobiology of autism.
Utrecht, Netherlands. In Eur J Pharmacol, 2013
The contactin (CNTN) family of Ig cell adhesion molecules (IgCAMs) harbours at least three members that have genetically been implicated in autism: CNTN4, CNTN5, and CNTN6.
Contactin 4 as an autism susceptibility locus.
Columbus, United States. In Autism Res, 2011
Using array comparative genome hybridization (CGH), we identified a maternally inherited approximately 535 kb deletion at 3p26.3 encompassing the 5' end of the contactin 4 gene (CNTN4) in a patient with autism.
Contactins: structural aspects in relation to developmental functions in brain disease.
Utrecht, Netherlands. In Adv Protein Chem Struct Biol, 2010
Genetics of neuropsychiatric disorders, particularly autism spectrum disorders, have pinpointed contactin-4, -5, and -6 (CNTN4, -5, and -6) as potential disease genes in neurodevelopmental disorders and suggested that they participate in pathways important for appropriate brain development.