gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SH3-domain GRB2-like endophilin B1

Bif-1, Endophilin B1, Bax-interacting factor-1, SH3GLB1
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Bax, endophilin, CAN, Beclin 1, bcl-2
Papers on Bif-1
A comparison of the amorphization of zeolitic imidazolate frameworks (ZIFs) and aluminosilicate zeolites by ball-milling.
New
Cheetham et al., Didcot, United Kingdom. In Dalton Trans, Dec 2015
UNASSIGNED: X-ray diffraction has been used to investigate the kinetics of amorphization through ball-milling at 20 Hz, for five zeolitic imidazolate frameworks (ZIFs) - ZIF-8, ZIF-4, ZIF-zni, BIF-1-Li and CdIF-1.
IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy.
New
Xu et al., Harbin, China. In Oncogene, Nov 2015
Moreover, IFNg and starvation-induced the co-localization of Irgm1 with Bax-interacting factor 1 (Bif-1).
Overexpression Bax interacting factor-1 protects cortical neurons against cerebral ischemia-reperfusion injury through regulation of ERK1/2 pathway.
New
Li et al., Beijing, China. In J Neurol Sci, Nov 2015
Bax interacting factor-1 (Bif-1), a multifunctional protein, can regulate cell apoptosis and autophagy.
Bax and Bif-1 proteins interact on Bilayer Lipid Membrane and form pore.
New
Ghosh et al., New Delhi, India. In Biochem Biophys Res Commun, Sep 2015
Bax and Bax interacting factor-1(Bif-1) are cytosolic proteins, which translocate towards mitochondria during mitochondria-mediated apoptosis.
Loss of endophilin-B1 exacerbates Alzheimer's disease pathology.
New
Morrison et al., Seattle, United States. In Brain, Jul 2015
Endophilin-B1, also known as Bax-interacting factor 1 (Bif-1, and encoded by SH3GLB1), is a multifunctional protein involved in apoptosis, autophagy and mitochondrial function.
Untangling knots between autophagic targets and candidate drugs, in cancer therapy.
Review
New
Liu et al., Chengdu, China. In Cell Prolif, Apr 2015
Autophagy can be regulated by a limited number of autophagy-related genes (Atgs) such as oncogenic Bcl-2/Bcl-XL , mTORC1, Akt and PI3KCI, and tumour suppressive proteins PI3KCIII, Beclin-1, Bif-1, p53, DAPKs, PTEN and UVRAG, which play their crucial roles in regulating autophagy-related cancer.
HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains.
New
Cheng et al., Penn Hills, United States. In Oncogene, Feb 2015
Tax facilitated autophagic process by activating inhibitor of κB (IκB) kinase (IKK) complex, which subsequently recruited an autophagy molecular complex containing Beclin1 and Bif-1 to the lipid raft microdomains.
Beclin-1 and its role as a target for anticancer therapy.
Review
Rybczynska et al., Poznań, Poland. In J Physiol Pharmacol, 2014
Beclin-1 is a protein that plays a central role in autophagy; it interacts with multiple cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, IP3R, PINK and survivin) to promote the formation of the Beclin-1-Vps34-Vps15 complex which triggers the autophagy protein cascade.
Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons.
Morrison et al., Seattle, United States. In J Neurosci, 2014
Bax-interacting factor 1 (Bif-1, also known as endophilin B1) is a multifunctional protein involved in the regulation of apoptosis, mitochondrial morphology, and autophagy.
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.
Impact
Liang et al., Los Angeles, United States. In Nat Cell Biol, 2013
Intriguingly, autophagy caused the dissociation of UVRAG from the ER tether, which in turn worked in concert with the Bif-1-beclin-1-PI(3)KC3 complex to mobilize Atg9 translocation for autophagosome formation.
Beclin-1: autophagic regulator and therapeutic target in cancer.
Review
Liu et al., Chengdu, China. In Int J Biochem Cell Biol, 2013
Recent data indicate that Beclin-1 may interact with some co-factors such as Class III phosphatidylinositol 3-kinase (PI3KCIII)/Vps34, Vps15, ATG14L/Barkor, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, Survivin, Akt and Bcl-2/Bcl-XL to positively or negatively orchestrate the Beclin-1 interactome, thereby co-regulating the autophagy process.
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.
Impact
GeneRIF
Ip et al., Hong Kong, Hong Kong. In Nat Cell Biol, 2011
findings not only establish Cdk5 as a critical regulator of autophagy induction, but also reveal a role for Cdk5 and EndoB1 in the pathophysiology of Parkinson's disease through modulating autophagy
Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma.
GeneRIF
Wang et al., Tampa, United States. In Pancreas, 2011
The expression of Bif-1 is downregulated in a subset of pancreatic ductal adenocarcinoma. This novel finding is in agreement with the tumor suppressor function of Bif-1.
The Beclin 1 network regulates autophagy and apoptosis.
Review
Tang et al., Pittsburgh, United States. In Cell Death Differ, 2011
It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP(3)R, PINK and survivin) to regulate the lipid kinase Vps-34 protein and promote formation of Beclin 1-Vps34-Vps15 core complexes, thereby inducing autophagy.
Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy.
GeneRIF
Wang et al., United States. In Autophagy, 2011
These findings suggest that Bif-1 acts as a critical regulator of Atg9 puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation.
GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death.
GeneRIF
Li et al., Kansas City, United States. In J Cell Sci, 2010
GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagic response and cell death.
Anti- and pro-tumor functions of autophagy.
Review
Kroemer et al., Villejuif, France. In Biochim Biophys Acta, 2009
Conversely, several tumor suppressor proteins (e.g., Atg4c; beclin 1; Bif-1; BH3-only proteins; death-associated protein kinase 1; LKB1/STK11; PTEN; UVRAG) promote the autophagic pathway.
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.
Impact
GeneRIF
Wang et al., Tampa, United States. In Nat Cell Biol, 2007
Bif-1 interacts with Beclin 1 through ultraviolet irradiation resistance-associated gene (UVRAG) and functions as a positive mediator of the class III PI(3) kinase (PI(3)KC3).
share on facebooktweetadd +1mail to friends