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Bicaudal C homolog 1

Bic-C, Bicc1
This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: CAN, Actin, NOT3, TGF-alpha, HAD
Papers on Bic-C
Bicaudal-C plays a vital role in oogenesis in Nilaparvata lugens (Hemiptera: Delphacidae).
Zhang et al., Hangzhou, China. In J Insect Physiol, Aug 2015
Bicaudal-C (Bic-C) was originally identified in a Drosophila melanogaster mutagenesis screen and plays vital roles in embryogenesis.
Determinants of RNA binding and translational repression by the Bicaudal-C regulatory protein.
Sheets et al., Madison, United States. In J Biol Chem, 2014
Bicaudal-C (Bic-C) RNA binding proteins function as important translational repressors in multiple biological contexts within metazoans.
bicaudal-C is required for the formation of anterior neurogenic ectoderm in the sea urchin embryo.
Inaba et al., Shimoda, Japan. In Sci Rep, 2013
bicaudal-C (bicC) mRNA encodes a protein containing RNA-binding domains that is reported to be maternally present with deflection in the oocytes/eggs of some species.
Bicaudal-C spatially controls translation of vertebrate maternal mRNAs.
Sheets et al., In Rna, 2013
Here, we show that the RNA binding protein, Bicaudal-C (Bic-C), functioned directly in this vegetal cell-specific repression.
Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
Constam et al., Lausanne, Switzerland. In J Mol Cell Biol, 2012
Bicc1 KH domains bind the 3' UTRs of AC6 and PKIa mRNAs and cognate miRNA precursors, whereas the SAM domain loads a silencing complex with AGO2. AC6 and PKIa protein levels increase in cystic Bicc1-/- mouse kidneys.
Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia.
Grapin-Botton et al., Lausanne, Switzerland. In Hum Mutat, 2012
The nonsense mutation identified in BICC1 and associated with cystic renal dysplasia results in a complete loss of Wnt inhibitory activity. The point mutation in the SAM domain results in a 22% loss of activity.
The Bic-C family of developmental translational regulators.
Lasko et al., Montréal, Canada. In Comp Funct Genomics, 2011
Among these, Bicaudal C constitutes a family of RNA binding proteins whose founding member was first identified in Drosophila and contains orthologs in vertebrates.
Loss of Bicc1 impairs tubulomorphogenesis of cultured IMCD cells by disrupting E-cadherin-based cell-cell adhesion.
Wu et al., Beijing, China. In Eur J Cell Biol, 2010
lack of Bicc1 leads to disruption of normal cell-cell junctions.
The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.
Wessely et al., New Orleans, United States. In Development, 2010
Data suggest that Bicc1 functions by modulating the expression of polycystin 2 (Pkd2 by antagonizing the repressive activity of the miR-17 microRNA family on the 3'UTR of Pkd2 mRNA.
Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow.
Constam et al., Lausanne, Switzerland. In Development, 2009
Data report that targeted inactivation of BicC randomizes left-right asymmetry by disrupting the planar alignment of motile cilia required for cilia-driven fluid flow, and that BicC can uncouple Dvl2 signaling from the canonical Wnt pathway.
Bicaudal-C associates with a Trailer Hitch/Me31B complex and is required for efficient Gurken secretion.
Lasko et al., Montréal, Canada. In Dev Biol, 2009
Bic-C associates with a Trailer Hitch/Me31B complex and is required for efficient Grk secretion.
K homology domains of the mouse polycystic kidney disease-related protein, Bicaudal-C (Bicc1), mediate RNA binding in vitro.
Bryda et al., Columbia, United States. In Nephron Exp Nephrol, 2007
Binds homoribopolymers in vitro; the third K homology domain is necessary and sufficient for in vitro Bicc1 RNA binding.
Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression.
Lasko et al., Montréal, Canada. In Dev Cell, 2007
Bic-C regulates expression of specific germline mRNAs by controlling their poly(A)-tail length.
Effect of aluminum on the production of siderophore by Rhizobium sp. (Cicer arietinum).
Chakrabartty et al., Calcutta, India. In Curr Microbiol, 2000
strain BICC 651 in the presence of 100 microM Al3+ produced a threefold higher level of siderophore than in the control culture under iron limitation during the stationary phase.
Bovine immunoglobulin concentrate-clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine.
Kelly et al., Boston, United States. In Gut, 1999
AIMS: To determine the proportion of BIC-C difficile which survives passage through the human stomach and small intestine.
Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C.
Lasko et al., Montréal, Canada. In Mol Cell Biol, 1998
Bicaudal-C (Bic-C) is required during Drosophila melanogaster oogenesis for several processes, including anterior-posterior patterning.
Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract.
Pothoulakis et al., Boston, United States. In Antimicrob Agents Chemother, 1997
This led us to study the gastrointestinal stability of orally administered BIC directed against Clostridium difficile toxins (BIC-C.
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