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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transmembrane BAX inhibitor motif containing 6

BI-1, Bax inhibitor-1, TEGT
Suppressor of apoptosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Bax, CAN, ACID, bcl-2, V1a
Papers on BI-1
BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival.
Methner et al., Mainz, Germany. In Cell Death Differ, Feb 2016
BAX (BCL2-associated X protein) inhibitor-1 (BI-1) is a Ca(2+) leak channel also implicated in the response against protein misfolding, thereby connecting the Ca(2+) store and protein-folding functions of the ER.
Overexpression of BAX INHIBITOR-1 Links Plasma Membrane Microdomain Proteins to Stress.
Kawai-Yamada et al., Saitama, Japan. In Plant Physiol, Oct 2015
BAX INHIBITOR-1 (BI-1) is a cell death suppressor widely conserved in plants and animals.
Pyrroloaryls and pyrroloheteroaryls: Inhibitors of the HIV fusion/attachment, reverse transcriptase and integrase.
Park et al., Olomouc, Czech Republic. In Bioorg Med Chem, Oct 2015
Such attempts were resulted in a discovery of highly potent anti-HIV agents suitable for clinical trials, for example, BMS-378806, BMS-585248, BMS-626529, BMS-663068, BMS-488043 and BMS-663749, etc. as anti-HIV attachment agents, triciribine, QX432, BI-1 and BI-2 as HIV RT inhibitors which are in preclinical or clinical development.
Unprecedentedly high formic acid dehydrogenation activity on an iridium complex with an N,N'-diimine ligand in water.
Li et al., Dalian, China. In Chemistry, Oct 2015
A turnover frequency (TOF) of 487 500 h(-1) with [Cp*Ir(L1)Cl]Cl (L1=2,2'-bi-2-imidazoline) at 90 °C and a turnover number (TON) of 2 400 000 with in situ prepared catalyst from [IrCp*Cl2 ]2 and 2,2'-bi-1,4,5,6-tetrahydropyrimidine (L2) at 80 °C were obtained, the highest values reported for FA dehydrogenation to date.
The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.
Methner et al., Mainz, Germany. In Biochim Biophys Acta, Sep 2015
Bax inhibitor-1 (BI-1) is an evolutionarily conserved pH-dependent Ca²⁺ leak channel in the endoplasmic reticulum and the founding member of a family of six highly hydrophobic mammalian proteins named transmembrane BAX inhibitor motif containing (TMBIM) 1-6 with BI-1 being TMBIM6.
Energetic Materials Based on 5,5'-Diamino-4,4'-dinitramino-3,3'-bi-1,2,4-triazole.
Stierstorfer et al., München, Germany. In Chem Asian J, Aug 2015
UNASSIGNED: A simple and straightforward synthesis of 5,5'-diamino-4,4'-dinitramino-3,3'-bi-1,2,4-triazole by the selective nitration of 4,4',5,5'-tetraamino-3,3'-bi-1,2,4-triazole is presented.
TMBIM protein family: ancestral regulators of cell death.
Hetz et al., Santiago, Chile. In Oncogene, Feb 2015
In the past years, a novel group of cell death regulators have emerged, known as the Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) protein family.
Bax inhibitor-1 is overexpressed in non-small cell lung cancer and promotes its progression and metastasis.
Zhou et al., Harbin, China. In Int J Clin Exp Pathol, 2014
Bax inhibitor-1 (BI-1) is a novel anti-apoptotic protein.
'Candidatus Phytoplasma phoenicium' associated with almond witches'-broom disease: from draft genome to genetic diversity among strain populations.
Bianco et al., Milano, Italy. In Bmc Microbiol, 2014
One of the integral membrane proteins was predicted as BI-1, an inhibitor of apoptosis-promoting Bax factor.
The Bax inhibitor MrBI-1 regulates heat tolerance, apoptotic-like cell death, and virulence in Metarhizium robertsii.
Wang et al., Shanghai, China. In Sci Rep, 2014
Bax inhibitor 1 (BI-1) is a highly conserved protein originally identified as a suppressor of the proapoptotic protein Bax to inhibit cell death in animals and plants.
Structural basis for a pH-sensitive calcium leak across membranes.
Liu et al., New York City, United States. In Science, 2014
Human Bax inhibitor-1 (hBI-1) is an antiapoptotic protein that mediates a calcium leak and is representative of a highly conserved and widely distributed family, the transmembrane Bax inhibitor motif (TMBIM) proteins.
The characteristics of Bax inhibitor-1 and its related diseases.
Chae et al., Iksan, South Korea. In Curr Mol Med, 2013
Bax inhibitor-1 (BI-1) is an evolutionarily-conserved endoplasmic reticulum protein.
The Janus face of reactive oxygen species in resistance and susceptibility of plants to necrotrophic and biotrophic pathogens.
Király et al., Budapest, Hungary. In Plant Physiol Biochem, 2012
The Janus face nature of ROS and plant cell death on biotrophic and on necrotrophic pathogens is also supported by the experiments with BAX inhibitor-1 and the mlo mutation of Mlo gene in barley.
Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy.
Reed et al., Los Angeles, United States. In Genes Dev, 2012
The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress.
Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.
Smith et al., Cambridge, United Kingdom. In J Biol Chem, 2012
Data indicate that GAAP and BI-1 have a six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop.
Bax inhibitor-1 regulates the expression of P450 2E1 through enhanced lysosome activity.
Chae et al., Iksan, South Korea. In Int J Biochem Cell Biol, 2012
BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation
Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic mice.
Cho et al., Seoul, South Korea. In Biochim Biophys Acta, 2012
BI-1-induced ERK1/2 activation plays an important role in the modulation of intracellular reactive oxygen species generation and apoptotic cell death and may also affect autoimmune response.
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
Methner et al., Leuven, Belgium. In J Biol Chem, 2012
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
The ancient cell death suppressor BAX inhibitor-1.
Methner et al., Düsseldorf, Germany. In Cell Calcium, 2011
Bax inhibitor-1 (BI-1) was initially identified for its ability to inhibit BAX-induced apoptosis in yeast cells and is the founding member of a family of highly hydrophobic proteins localized in diverse cellular membranes.
Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY.
Silhavy et al., Princeton, United States. In Science, 2009
Intriguingly, YccA is a functional homolog of the proto-oncogene product Bax Inhibitor-1, which may share a similar mechanism of action in regulating apoptosis upon prolonged secretion stress.
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