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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Transmembrane BAX inhibitor motif containing 6

BI-1, Bax inhibitor-1, TEGT
Suppressor of apoptosis [RGD, Feb 2006] (from NCBI)
Papers on BI-1
Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy.
GeneRIF
Reed et al., Los Angeles, United States. In Genes Dev, 2012
The results reveal BI-1 as a novel autophagy regulator that bridges Ca(2) signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress.
Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.
GeneRIF
Smith et al., Cambridge, United Kingdom. In J Biol Chem, 2012
Data indicate that GAAP and BI-1 have a six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop.
Bax inhibitor-1 regulates the expression of P450 2E1 through enhanced lysosome activity.
GeneRIF
Chae et al., Iksan, South Korea. In Int J Biochem Cell Biol, 2012
BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation
Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic mice.
GeneRIF
Cho et al., Seoul, South Korea. In Biochim Biophys Acta, 2012
BI-1-induced ERK1/2 activation plays an important role in the modulation of intracellular reactive oxygen species generation and apoptotic cell death and may also affect autoimmune response.
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
GeneRIF
Methner et al., Leuven, Belgium. In J Biol Chem, 2012
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
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