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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Betaine--homocysteine S-methyltransferase

BHMT, Betaine-Homocysteine S-Methyltransferase, betaine-homocysteine methyltransferase
This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, methylenetetrahydrofolate reductase, fibrillin-1
Papers on BHMT
Creatine supplementation prevents hyperhomocysteinemia, oxidative stress and cancer-induced cachexia progression in Walker-256 tumor-bearing rats.
Guarnier et al., Londrina, Brazil. In Amino Acids, Feb 2016
Impaired Hcy metabolism was evidenced by decreased hepatic betaine-homocysteine methyltransferase (Bhmt), glycine N-methyltransferase (Gnmt) and cystathionine beta synthase (CBS) gene expression.
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
Zhao et al., Nanjing, China. In Sci Rep, Dec 2015
Homocysteine concentration in follicular fluid was significantly higher in PCO group, which was associated with significantly up-regulated one-carbon metabolic enzymes betaine homocysteine methyltransferase (BHMT), glycine N-methyltransferase (GNMT) and the DNA methyltransferase DNMT1.
Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.
Varela-Nieto et al., Madrid, Spain. In J Nutr Biochem, Dec 2015
Genes involved in homocysteine metabolism showed decreased expression during aging of control animals, and only alterations in Bhmt and Cbs were significantly prevented by omega-3 feeding.
Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.
Zhao et al., Nanjing, China. In J Agric Food Chem, Dec 2015
Concurrently, maternal betaine supplementation increased the plasma betaine concentration and muscle expression of methyl transfer enzymes (p < 0.05), BHMT and GNMT, in offspring piglets.
Downregulation of betaine homocysteine methyltransferase (BHMT) in hepatocellular carcinoma associates with poor prognosis.
Pan et al., Jinan, China. In Tumour Biol, Dec 2015
UNASSIGNED: Betaine homocysteine methyltransferase (BHMT) catalyzes the synthesis of methionine using betaine and homocysteine (Hcy), which is restricted to the liver and kidney.
Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis.
McDonough et al., Auckland, New Zealand. In J Neurosci, Dec 2015
We also found expression of the enzyme betaine homocysteine methyltransferase in cortical neurons.
Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo.
Stipanuk et al., Ithaca, United States. In Amino Acids, Nov 2015
Using these mouse models, we identified betaine:homocysteine methyltransferase (BHMT) as a protein whose in vivo expression is robustly regulated by taurine.
Differential proteomic and tissue expression analyses identify valuable diagnostic biomarkers of hepatocellular differentiation and hepatoid adenocarcinomas.
Baba et al., Dortmund, Germany. In Pathology, Oct 2015
Eight non-redundant, differentially expressed proteins were suitable for further immunohistochemical validation and four (ABAT, BHMT, FABP1, HAOX1) for further evaluation.
Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet--CORRIGENDUM.
Feng et al., In Br J Nutr, Oct 2015
In the abstract, these sentences (page 1, line 5) should be: 'Additionally, hepatic betaine-homocysteine methyltransferase concentration as well as its mRNA abundance and lecithin level were found increased (P < 0. 05) by betaine supplementation in both basal diet-fed rats and high-fat diet-fed rats.
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease.
Sanyal et al., Gainesville, United States. In Plos One, 2014
Protein expression of methionine adenosyltransferase 1A, cystathionine β-synthase, γ-glutamylcysteine synthetase, betaine-homocysteine methyltransferase, and methionine synthase remained unchanged.
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Obeid, Homburg, Germany. In Nutrients, 2013
Methyl groups are important for numerous cellular functions such as DNA methylation, phosphatidylcholine synthesis, and protein synthesis.
Betaine homocysteine methyltransferase (BHMT)-dependent remethylation pathway in human healthy and tumoral liver.
Pellanda, Vandœuvre-lès-Nancy, France. In Clin Chem Lab Med, 2013
We aimed to investigate betaine homocysteine methyltransferase (BHMT) expression in HepG2 cells and human hepatocarcinoma tissues.
Folate gene polymorphisms MTR A2756G, MTRR A66G, and BHMT G742A and risk for coronary artery disease: a meta-analysis.
Lele et al., Mumbai, India. In Genet Test Mol Biomarkers, 2012
Known common single-nucleotide polymorphisms in MTRR and BHMT genes may not be significant risk factors for cororonary artery disease.
BHMT G742A and MTHFD1 G1958A polymorphisms and Down syndrome risk in the Brazilian population.
Pavarino et al., Ribeirão Preto, Brazil. In Genet Test Mol Biomarkers, 2012
Our study suggests that the polymorphism BHMT G742A may modulate the Down syndrome risk in Brazilian mothers.
The role of zinc in genomic stability.
Fenech et al., Adelaide, Australia. In Mutat Res, 2012
Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle.
A splicing variant leads to complete loss of function of betaine-homocysteine methyltransferase (BHMT) gene in hepatocellular carcinoma.
Forges et al., Nancy, France. In Int J Biochem Cell Biol, 2012
A transcription variant of exon 4 of betaine-homocysteine methyltransferase (BHMT) produces a loss of function of BHMT in human hepatocarcinoma
Depletion of Bhmt elevates sonic hedgehog transcript level and increases β-cell number in zebrafish.
Peng et al., Singapore, Singapore. In Endocrinology, 2011
function for Bhmt involving modulation of Shh signaling to control beta-cell development.
Vitamin B6 deficiency, genome instability and cancer.
Lu et al., Kunming, China. In Asian Pac J Cancer Prev, 2011
It comprises a group of three related 3-hydroxy-2-methyl-pyrimidine derivatives: pyridoxine (PN), pyridoxal (PL), pyridoxamine (PM) and their phosphorylated derivatives [pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP)], In the folate metabolism pathway, PLP is a cofactor for the mitochondrial and cytoplasmic isozymes of serine hydroxymethyltransferase (SHMT2 and SHMT1), the P-protein of the glycine cleavage system, cystathionine β-synthase (CBS) and γ-cystathionase, and betaine hydroxymethyltransferase (BHMT), all of which contribute to homocysteine metabolism either through folate- mediated one-carbon metabolism or the transsulfuration pathway.
The human crystallin gene families.
Wistow, Bethesda, United States. In Hum Genomics, 2011
In the developing human lens, the enzyme betaine-homocysteine methyltransferase serves such a role.
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