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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PHD finger protein 21A

The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: Histone, BRAF, CoREST, HDAC, REST
Papers on BHC80
A microdeletion encompassing PHF21A in an individual with global developmental delay and craniofacial anomalies.
Kim et al., Augusta, United States. In Am J Med Genet A, Dec 2015
The PSS-associated genes EXT2 and ALX4, together with PHF21A, all map to this region flanked by markers D11S1393 and D11S1319.
HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition.
Reyes et al., Sevilla, Spain. In Oncogene, Nov 2015
Both proteins interact through a coiled-coil domain with BHC80, another subunit of the LSD1-CoREST complex.
Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.
Iwase et al., Ann Arbor, United States. In Epigenomics, 2014
We describe four H3K4me methyltransferases (KMT2A, KMT2C, KMT2D, KMT2F), four demethylases (KDM1A, KDM5A, KDM5B, KDM5C), and two reader proteins (PHF21A, PHF8) mutated in neurodevelopmental disorders.
[Impaired effect of BHC80 gene knock-down on the cardiac development in zebrafish].
Wang et al., Shanghai, China. In Sheng Li Xue Bao, 2013
The effect of BHC80 (a component of BRAF-HDAC complex) on development was not well studied, because BHC80 gene knock-out mice died in one day after birth.
A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia.
Aylsworth et al., Chapel Hill, United States. In Am J Med Genet A, 2013
This deletion results in haploinsufficiency for all or portions of six OMIM genes: SLC35C1, CRY2, MAPK8IP1, PEX16, GYLTL1B, and PHF21A.
Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies.
Gusella et al., Boston, United States. In Am J Hum Genet, 2012
we have uncovered evidence that the ID and CFA phenotypes are both caused by haploinsufficiency of a single gene, PHF21A, at 11p11.2.
The rest repression of the neurosecretory phenotype is negatively modulated by BHC80, a protein of the BRAF/HDAC complex.
D'Alessandro et al., Milano, Italy. In J Neurosci, 2009
the recovery of neurosecretion depends on the reciprocal level of BHC80 and REST, with BHC80 working as a negative modulator of REST repression
Esco2 is a novel corepressor that associates with various chromatin modifying enzymes.
Kim et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, 2008
Here, we report that Esco2 interacts with several component proteins of the CoREST complex, including a transcription corepressor CoREST, histone demethlyase LSD1, HDAC1, HDAC2, BRAF35, and PHF21A.
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.
Shi et al., Boston, United States. In Nature, 2007
The LSD1 complex contains a number of proteins, all of which have been assigned roles in events upstream of LSD1-mediated demethylation apart from BHC80 (also known as PHF21A), a plant homeodomain (PHD) finger-containing protein.
A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice.
Baba et al., Tsukuba, Japan. In Febs Lett, 2006
BHC80 is a component of BRAF-HDAC complex (BHC) involved in transcriptional repression of neuron-specific genes in non-neuronal cells.
Regulation of LSD1 histone demethylase activity by its associated factors.
Shi et al., Boston, United States. In Mol Cell, 2005
LSD1 is associated with HDAC1/2; CoREST, a SANT domain-containing corepressor; and BHC80, a PHD domain-containing protein, among others.
Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.
Baba et al., Tsukuba, Japan. In Biochem Biophys Res Commun, 2004
Presumably serves as a scaffold protein in BHC in neuronal as well as non-neuronal cells. Possible role in spermatogenesis.
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.
Shiekhattar et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2002
Similar to NuRD, BHC contains an Mi2-like subunit, BHC80, and a PHD zinc-finger subunit as well as histone deacetylases 1/2 and an MTA-like subunit, the transcriptional corepressor CoREST.
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