Adenylating enzymes in Mycobacterium tuberculosis as drug targets.
Minneapolis, United States. In Curr Top Med Chem, 2011
Additionally, the enzymes NadE, GuaA, PanC, and MshC involved in the respective synthesis of NAD, guanine, pantothenate, and mycothiol will be discussed as well as BirA that is responsible for biotinylation of the acyl CoA-carboxylases.
The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners.
Vienna, Austria. In Mutat Res, 2008
Besides tuberin, the proteins DOCK7, ezrin/radixin/moesin, FIP200, IKKbeta, Melted, Merlin, NADE(p75NTR), NF-L, Plk1 and TBC7 have been found to interact with hamartin.
The TSC1 gene product hamartin interacts with NADE.
Yonago, Japan. In Mol Cell Neurosci, 2007
hamartin binds to NADE to regulate neuronal cell function and loss of this association is likely to contribute to the brain pathology in tuberous sclerosis complex
Exoenzyme S binds its cofactor 14-3-3 through a non-phosphorylated motif.
Umeå, Sweden. In Biochem Soc Trans, 2002
Recently, a phosphorylation-independent interaction has been reported to occur between 14-3-3 and a small number of proteins, for example the 43 kDa inositol polyphosphate 5-phosphatase, glycoprotein Ib, p75NTR-associated cell-death executor (NADE) and the bacterial ADP-ribosyltransferase toxin exoenzyme S (ExoS).