Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion.
Rochester, United States. In Am J Physiol Gastrointest Liver Physiol, 2014
We assessed associations of candidate genes controlling BA metabolism (KLB rs17618244 and FGFR4 rs351855), BA receptor (GPBAR1 rs11554825), serotonin (5-HT) reuptake (SLC6A4 through rs4795541 which encodes for the 44-bp insert in 5HTTLPR), or immune activation (TNFSF15 rs4263839) with three primary quantitative traits of interest: colonic transit, BA synthesis, and fecal BA excretion.
Stressed Liver and Muscle Call on Adipocytes with FGF21.
Houston, United States. In Front Endocrinol (lausanne), 2012
A recent wave of studies has revealed that FGF21 is a stress-induced endocrine factor in liver, muscle, and other tissues that targets adipose tissue and adipocytes through the FGFR1-betaKlotho complex.
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome.
Rochester, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
The second objective is to review pharmacogenetics in IBS, with the focus on cytochrome P-450 metabolism of drugs used in IBS, modulation of motor and sensory responses to serotonergic agents based on the 5-hydroxytryptamine (5-HT) transporter-linked polymorphic region (5-HTTLPR) and 5-HT(3) genetic variants, responses to a nonselective cannabinoid agonist (dronabinol) based on cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) variation, and responses to a bile acid (sodium chenodeoxycholate) and bile acid binding (colesevelam) based on klothoβ (KLB) and fibroblast growth factor receptor 4 (FGFR4) variation.
Klotho and βKlotho.
Dallas, United States. In Adv Exp Med Biol, 2011
function of Klotho family proteins
The Klotho gene family and the endocrine fibroblast growth factors.
Tokyo, Japan. In Curr Opin Nephrol Hypertens, 2008
PURPOSE OF REVIEW: This review summarizes recent progress in understanding of Klotho and betaKlotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23).