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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Klotho beta

betaKlotho, KLB, Bkl
Top mentioned proteins: FGF19, ACID, FGF21, FGFR4, Klotho
Papers on betaKlotho
Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice.
Ren et al., Harbin, China. In Dig Dis Sci, Oct 2015
To understand the mechanisms, we compared the expression of βklotho (KLB) and oxidative stress level in the livers between the mice treated with FGF-21 and saline.
Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals.
Ortiz et al., Merced, United States. In Gen Comp Endocrinol, Jun 2015
Thus, to better understand the impact of prolonged food deprivation on FGF21-associated changes, we analyzed the expression of FGF21, FGF receptor-1 (FGFR1), β-klotho (KLB; a co-activator of FGFR) in adipose, and plasma FGF21, glucose and 3-hydroxybutyrate in fasted elephant seal pups.
First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.
Guzi et al., Cambridge, United States. In Cancer Discov, Apr 2015
Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.
Paralog-Specific Kinase Inhibition of FGFR4: Adding to the Arsenal of Anti-FGFR Agents.
Pollock et al., Brisbane, Australia. In Cancer Discov, Apr 2015
BLU9931 induces tumor shrinkage in hepatocellular carcinoma models that express a functioning ligand/receptor complex consisting of FGF19/FGFR4/KLB and adds to a growing list of anti-FGFR4 agents.
Placental fibroblast growth factor 21 is not altered in late-onset preeclampsia.
Barrett et al., Australia. In Reprod Biol Endocrinol, 2014
Placental mRNA expression of the FGF receptors (1-4) and the co-receptor beta-Klotho was not different between the groups.
Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows.
Loor et al., Urbana, United States. In Plos One, 2014
In experiment 1, induction of ketosis through feed restriction on d 5 postpartum upregulated FGF21, its co-receptor KLB, and PPARA but only elicited a numerical increase in serum FGF21 concentration.
Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice.
Talukdar et al., Cambridge, United States. In Plos One, 2014
FGF21 exerts its metabolic effects through formation of beta-klotho (KLB)/FGF receptor 1c FGFR1c complex and subsequent signaling.
Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea.
Zinsmeister et al., Rochester, United States. In Am J Gastroenterol, 2014
BA synthesis-related genes (KLB and FGFR4) are associated with colonic transit (CT) in IBS-D.
Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion.
Zinsmeister et al., Rochester, United States. In Am J Physiol Gastrointest Liver Physiol, 2014
We assessed associations of candidate genes controlling BA metabolism (KLB rs17618244 and FGFR4 rs351855), BA receptor (GPBAR1 rs11554825), serotonin (5-HT) reuptake (SLC6A4 through rs4795541 which encodes for the 44-bp insert in 5HTTLPR), or immune activation (TNFSF15 rs4263839) with three primary quantitative traits of interest: colonic transit, BA synthesis, and fecal BA excretion.
Enrichment and individual housing reinforce the differences in aggressiveness and amphetamine response in 129S6/SvEv and C57BL/6 strains.
Vasar et al., Tartu, Estonia. In Behav Brain Res, 2014
We observed common inbred mouse strains 129S6/SvEv/Tac (129) and C57BL/6 Bkl (B6) reared in 3 different environments: standard housing (SH), individual housing (IH) and enriched environment (EE).
Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19.
Ling et al., San Francisco, United States. In Cancer Res, 2014
Although it is well established that FGF19 acts through the receptor complex FGFR4-β-Klotho (KLB) to regulate bile acid metabolism, FGF19 is also implicated in the development of HCC.
Stressed Liver and Muscle Call on Adipocytes with FGF21.
McKeehan et al., Houston, United States. In Front Endocrinol (lausanne), 2012
A recent wave of studies has revealed that FGF21 is a stress-induced endocrine factor in liver, muscle, and other tissues that targets adipose tissue and adipocytes through the FGFR1-betaKlotho complex.
Dynamics and Distribution of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex.
Rocheleau et al., Toronto, Canada. In J Biol Chem, 2012
KLB and FGFR1 form a 1:1 heterocomplex independent of the galectin lattice that transitions to a 1:2 complex upon the addition of FGF21.
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome.
Katzka et al., Rochester, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
The second objective is to review pharmacogenetics in IBS, with the focus on cytochrome P-450 metabolism of drugs used in IBS, modulation of motor and sensory responses to serotonergic agents based on the 5-hydroxytryptamine (5-HT) transporter-linked polymorphic region (5-HTTLPR) and 5-HT(3) genetic variants, responses to a nonselective cannabinoid agonist (dronabinol) based on cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) variation, and responses to a bile acid (sodium chenodeoxycholate) and bile acid binding (colesevelam) based on klothoβ (KLB) and fibroblast growth factor receptor 4 (FGFR4) variation.
A unique FGF23 with the ability to activate FGFR signaling through both αKlotho and βKlotho.
Li et al., San Francisco, United States. In J Mol Biol, 2012
In contrast to wild-type FGF23, FGF23-21c (a variant of FGF23 where the C-terminal domain of FGF23 was replaced with the corresponding regions from FGF21), FGF23-21c gained the ability to activate FGFR1c and FGFR2c in the presence of betaKlotho.
Klotho and βKlotho.
Kuro-o, Dallas, United States. In Adv Exp Med Biol, 2011
function of Klotho family proteins
Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma.
Ho et al., Singapore, Singapore. In Mol Cancer, 2011
KLB-silencing in Huh7 cells decreased cell proliferation and suppressed FGFR4 downstream signaling.
Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.
Luo et al., Houston, United States. In Plos One, 2011
Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.
The Klotho gene family as a regulator of endocrine fibroblast growth factors.
Kuro-O et al., Tokyo, Japan. In Mol Cell Endocrinol, 2009
In addition to the Klotho-FGF23 axis, recent studies has shown that betaKlotho, a Klotho family protein, also functions as a cofactor required for FGF19 and FGF21 signaling and determines the tissue-specific metabolic activities of FGF19 and FGF21.
The Klotho gene family and the endocrine fibroblast growth factors.
Kuro-o et al., Tokyo, Japan. In Curr Opin Nephrol Hypertens, 2008
PURPOSE OF REVIEW: This review summarizes recent progress in understanding of Klotho and betaKlotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23).
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