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Beta-1,4-N-acetyl-galactosaminyl transferase 3
beta4GalNAc-T3, beta1,4-N-acetylgalactosaminyltransferase III, AB114826
B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008] (from
Narimatsu et al., Tsukuba, Japan. In Glycobiology, 2006
supra-nuclear expression of beta4GalNAc-T3 is essential for the formation of LacdiNAc on the surface mucous cells and that LacdiNAc and beta4GalNAc-T3 are novel differentiation markers of surface mucous cells in the gastric mucosa.