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UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5

beta3Gal-T5, B3galt5, beta3GalT-V, beta1,3-galactosyltransferase 5
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linked glycoproteins and functions in mucin glycosylation. Five transcript variants have been described which differ in the 5' UTR. All transcript variants encode an identical protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, glycosyltransferase, Cho, STEP
Papers on beta3Gal-T5
Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways.
New
Reis et al., Porto, Portugal. In Biochim Biophys Acta, Sep 2015
This study shows that H. pylori chronic infection and gastric tissue inflammation result in a remodeling of the gastric glycophenotype with increased expression of sialyl-Lewis a/x antigens due to transcriptional up-regulation of the B3GNT5, B3GALT5, and FUT3 genes.
A Panel of Recombinant Mucins Carrying a Repertoire of Sialylated O-Glycans Based on Different Core Chains for Studies of Glycan Binding Proteins.
Holgersson et al., Göteborg, Sweden. In Biomolecules, 2014
Besides stably expressing P-selectin glycoprotein ligand-1/mouse immunoglobulin G2b cDNA (PSGL-1/mIgG2b), CHO cells were stably transfected with plasmids encoding glycosyltransferases to synthesize core 2 (GCNT1), core 3 (B3GNT6), core 4 (GCNT1 and B3GNT6), or extended core 1 (B3GNT3) chains with or without the type 1 chain-encoding enzyme B3GALT5 and ST6GAL1.
Transcriptional control of the B3GALT5 gene by a retroviral promoter and methylation of distant regulatory elements.
Trinchera et al., Varese, Italy. In Faseb J, 2014
We focused on transcription factors and epigenetic marks that regulate the B3GALT5 gene through its retroviral long terminal repeat (LTR) promoter.
Control of Glycosylation-Related Genes by DNA Methylation: the Intriguing Case of the B3GALT5 Gene and Its Distinct Promoters.
Review
Dall'Olio et al., Varese, Italy. In Biology (basel), 2013
The aim of the present review is to briefly describe some relevant examples of glycosylation-related genes whose DNA methylation has been implicated in their regulation and to focus on the intriguing case of a glycosyltransferase gene (B3GALT5).
DNA methylation and histone modifications modulate the β1,3 galactosyltransferase β3Gal-T5 native promoter in cancer cells.
GeneRIF
Trinchera et al., Milano, Italy. In Int J Biochem Cell Biol, 2012
Chromatin immunoprecipitation assays on beta3Gal-T5 promoter showed that histone H3K4 trymethylation, H3K79 dimethylation, and H3K9-14 acetylation are high in cells expressing the transcript.
Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.
GeneRIF
Yaspo et al., Berlin, Germany. In Nucleic Acids Res, 2010
The B3GALT5 promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells.
Analysis of differential expression of glycosyltransferases in healing corneas by glycogene microarrays.
Panjwani et al., Boston, United States. In Glycobiology, 2010
Among them, notably, glycosyltransferases, beta3GalT5, T-synthase, and GnTIVb, were all found to be induced in the corneas in response to injury, whereas, GnTIII and many sialyltransferases were downregulated.
Detection of differentially expressed wound-healing-related glycogenes in galectin-3-deficient mice.
Panjwani et al., United Kingdom. In Invest Ophthalmol Vis Sci, 2009
A galactosyltransferase, beta3GalT5, which has the ability to synthesize Gal-3 ligands was markedly downregulated in healing Gal-3(-/-) corneas.
Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines.
GeneRIF
Khoo et al., Taipei, Taiwan. In Glycobiology, 2009
the enhanced expression of beta 3GalT5 is sufficient to promote in vivo extension of type 1 chains by furnishing a significantly higher amount of type 1 chain precursors relative to competing type 2 chains.
Mucosal gene expression profiles following the colonization of immunocompetent defined-flora C3H mice with Helicobacter bilis: a prelude to typhlocolitis.
Wannemuehler et al., Ames, United States. In Microbes Infect, 2009
A set of genes associated with glycoprotein synthesis and detoxification including Fut2, B3galt5, Ceacam12, Cyp4b1, and Ugt8a were uniquely identified and found to be similarly expressed following the induction of typhlocolitis by dextran sodium sulfate or Brachyspira hyodysenteriae.
Beta1,3-galactosyltransferases-4/5 are novel tumor markers for gynecological cancers.
GeneRIF
Yamashita et al., Yokohama, Japan. In Tumour Biol, 2008
We found beta3Gal-T4 and T5 enzymatic activity in ovarian cancer tissues, indicating that these enzymes are expressed at least in ovarian cancer
Proteomic identification of specific glycosyltransferases functionally implicated for the biosynthesis of a targeted glyco-epitope.
Khoo et al., Taipei, Taiwan. In Proteomics, 2008
Applying the strategy to a colonic adenocarcinoma, Colo205, which is known to aberrantly synthesize abundant fucosylated extended type 1 chain, we first validated that beta3-galactosyltransferase 5 (beta3GalT5) is indeed the overexpressed beta3GalT.
A beta-1,3-galactosyltransferase and brainiac/bre5 homolog expressed in the midgut did not contribute to a Cry1Ab toxin resistance trait in Ostrinia nubilalis.
Lewis et al., Ames, United States. In Insect Biochem Mol Biol, 2007
A 931bp cDNA encoding a putative 297-residue beta-1,3-galactosyltransferase (beta3GalT5) was cloned from larval Ostrinia nubilalis midgut tissue, and showed homology to Drosophila brainiac (brn) and Caenorhabditis elegans bre5 proteins.
Comparative analysis of retroviral and native promoters driving expression of beta1,3-galactosyltransferase beta3Gal-T5 in human and mouse tissues.
Trinchera et al., Varese, Italy. In J Biol Chem, 2007
Beta1,3-galactosyltransferase beta3Gal-T5 is highly expressed in the colons of humans and certain primates due to a retroviral long terminal repeat (LTR) acting as a strong promoter.
Glycosyltransferases involved in type 1 chain and Lewis antigen biosynthesis exhibit glycan and core chain specificity.
Löfling et al., Huddinge, Sweden. In Glycobiology, 2006
beta3Gal-T1, -T2, and -T5 could synthesize type 1 chains on N-linked glycans, but only beta3Gal-T5 worked on O-linked glycans.
Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5.
GeneRIF
Mager et al., Vancouver, Canada. In Gene, 2006
case study of the endogenous retrovirus long terminal repeat promoter of this enzyme, beta1,3-galactosyltransferase 5
A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity.
O'Donovan et al., Cardiff, United Kingdom. In Gene Expr, 2003
The functional variants were distributed across the promoters of CRYAA, IFNAR1, KCNJ15, NCAM2, IGSF5, and B3GALT5.
Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue.
Monden et al., Ōsaka, Japan. In Pathobiology, 2003
Recently, beta3Gal-T5 has been presumed to be related to the formation of the type 1 chain in an in vitro experiment in terms of kinetic enzyme characterization.
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